INT105746

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Context Info
Confidence 0.39
First Reported 2002
Last Reported 2009
Negated 5
Speculated 0
Reported most in Body
Documents 22
Total Number 23
Disease Relevance 7.60
Pain Relevance 7.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neck 2
plasma 1
thalamus 1
tail skin 1
ECT (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 37 100.00 Very High Very High Very High
Lasting pain 4 99.80 Very High Very High Very High
anesthesia 18 99.68 Very High Very High Very High
intrathecal 280 99.20 Very High Very High Very High
Spinal cord 353 99.16 Very High Very High Very High
depression 212 99.08 Very High Very High Very High
antinociception 353 98.82 Very High Very High Very High
tricyclic antidepressant 18 98.06 Very High Very High Very High
agonist 256 97.92 Very High Very High Very High
Paracetamol 1 97.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 54 100.00 Very High Very High Very High
Cognitive Disorder 52 99.98 Very High Very High Very High
Paralysis 72 99.82 Very High Very High Very High
Depression 266 99.80 Very High Very High Very High
Schizophrenia 4 99.00 Very High Very High Very High
Suicidal Behaviour 17 98.96 Very High Very High Very High
Catatonia 5 98.40 Very High Very High Very High
Hypercalcemia 3 98.30 Very High Very High Very High
Manic Depressive Disorder 2 97.80 Very High Very High Very High
Hyperaldosteronism 2 93.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Electroconvulsive therapy (ECT) was introduced in its current form by Cerletti and Bini in 1938 [1].
Regulation (introduced) of ECT
1) Confidence 0.39 Published 2007 Journal BMC Psychiatry Section Body Doc Link PMC1929082 Disease Relevance 0.06 Pain Relevance 0
METHODS: The study comprised a total of 14 patients receiving ECT who experienced a severe headache for 2 successive ECT treatments or 2 of their last 4 treatments and who had only partial or no response to usual analgesic treatment for their headache.
Neg (no) Regulation (response) of ECT
2) Confidence 0.39 Published 2008 Journal J ECT Section Body Doc Link 18580561 Disease Relevance 0.06 Pain Relevance 0
BACKGROUND: Electroconvulsive therapy (ECT) is reported to be effective for intractable chronic pain with depression.
Regulation (effective) of ECT associated with depression and lasting pain
3) Confidence 0.39 Published 2009 Journal Med. Sci. Monit. Section Abstract Doc Link 19333208 Disease Relevance 0.85 Pain Relevance 0.64
The risk associated with ECT has also been reduced with the introduction of refined ECT procedures, such as "maintenance ECT" or "unilateral ECT" (uECT) [5].
Regulation (introduction) of ECT
4) Confidence 0.36 Published 2004 Journal Ann Gen Hosp Psychiatry Section Body Doc Link PMC514898 Disease Relevance 0.48 Pain Relevance 0.09
The risk associated with ECT has also been reduced with the introduction of refined ECT procedures, such as "maintenance ECT" or "unilateral ECT" (uECT) [5].
Regulation (introduction) of ECT
5) Confidence 0.36 Published 2004 Journal Ann Gen Hosp Psychiatry Section Body Doc Link PMC514898 Disease Relevance 0.47 Pain Relevance 0.09
There was no difference in ECT parameters between the depression groups (Table 2).
Neg (no) Regulation (difference) of ECT associated with depression
6) Confidence 0.34 Published 2002 Journal BMC Psychiatry Section Body Doc Link PMC65527 Disease Relevance 0.41 Pain Relevance 0.17
We used propofol and suxamethonium to induce anesthesia, and measured plasma levels of aldosterone to evaluate the influence of ECT during anesthesia.
Regulation (influence) of ECT in plasma associated with anesthesia
7) Confidence 0.23 Published 2003 Journal Masui Section Abstract Doc Link 12795135 Disease Relevance 0.17 Pain Relevance 0.20
While ECT significantly improved Hamilton depression score (from mean 23.9 (SD:5) to mean 12.5 (SD:5.7)) there was no significant change in pain thresholds during and after ECT in the patient group.
Neg (no) Regulation (change) of ECT associated with pain and depression
8) Confidence 0.23 Published 2004 Journal Eur J Pain Section Abstract Doc Link 15324780 Disease Relevance 1.35 Pain Relevance 1.35
Further studies may eventually demonstrate efficacy of ECT for intractable neuropathic pain syndromes.


Regulation (efficacy) of ECT
9) Confidence 0.23 Published 2004 Journal Pain Physician Section Body Doc Link 16868601 Disease Relevance 0.07 Pain Relevance 0
CONCLUSIONS: The results from the SPECT suggest that normalization of the balance of rCBF in the thalamus may be related to the analgesic efficacy of the ECT on CRPS Type-1.


Regulation (efficacy) of ECT in thalamus
10) Confidence 0.22 Published 2002 Journal Reg Anesth Pain Med Section Body Doc Link 12373706 Disease Relevance 0 Pain Relevance 0
We view this as a reasonable trade-off to document the current finding and inspire new science related to the cognitive affects of ECT.
Regulation (affects) of ECT associated with cognitive disorder
11) Confidence 0.21 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2526376 Disease Relevance 0.30 Pain Relevance 0
Further data on costs and outcomes for ECT need to be collected over a longer time frame.
Regulation (collected) of ECT
12) Confidence 0.17 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504052 Disease Relevance 0.60 Pain Relevance 0
Third, it has been reported that NSAIDs such as ibuprofene and acetaminophen affect bone resorption markers including urinary NTX.30 The simultaneous use of these drugs may modify the effect of ALN and/or ECT on bone markers.
Regulation (effect) of ECT associated with paracetamol, cinod and hypercalcemia
13) Confidence 0.14 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2710382 Disease Relevance 0.45 Pain Relevance 0.38
Greenhalgh et al62 reviewed the evidence of clinical and cost-effectiveness of ECT for depressive illness, schizophrenia, catatonia, and mania.
Regulation (effectiveness) of ECT associated with manic depressive disorder, depression, catatonia and schizophrenia
14) Confidence 0.05 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2781064 Disease Relevance 0.78 Pain Relevance 0.46
Paralysis did not affect ECT readings because vocalisation was the response and also the end point.
Neg (not) Regulation (affect) of ECT associated with paralysis
15) Confidence 0.05 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC137595 Disease Relevance 0.29 Pain Relevance 0.57
If the drug remains confined to the caudal segments of spinal cord then a rise in tail ECT is noted with no effect on neck ECT.
Neg (no) Regulation (effect) of ECT in neck associated with spinal cord
16) Confidence 0.03 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC137595 Disease Relevance 0.22 Pain Relevance 0.67
For major depression, they concluded ECT to be probably more effective than pharmacotherapy in the short term; that TCAs might improve ECT effects during the treatment; and that there is limited evidence of long-term efficacy of ECT and the impact of ECT on suicide and all-cause mortality.
Regulation (efficacy) of ECT associated with suicidal behaviour, depression and tricyclic antidepressant
17) Confidence 0.03 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2781064 Disease Relevance 0.77 Pain Relevance 0.35
Logistic regression (y = a loge(x)+b) using sums of squares was performed on these spinal data (where ECT neck value was within the 95% confidence intervals of the neck data in control experiments with 8% dextrose).
Regulation (value) of ECT in neck
18) Confidence 0.02 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC137595 Disease Relevance 0 Pain Relevance 0.22
When spinally confined (i.e. when there was an ECT value in the neck that was not significantly different from the neck ECT values obtained with 8% dextrose controls) there was significant antinociception when assessed by ECT at the tail skin site (figure 5; p < 0.01, at the highest dose) although there was a large scatter of results and a shallow dose response regression line.
Regulation (value) of ECT in tail skin associated with antinociception
19) Confidence 0.02 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC137595 Disease Relevance 0.07 Pain Relevance 0.40
Thus each time point after all doses of agonist given in an experiment where the lignocaine test was positive yielded three values, an ECT (n) with the corresponding ECT (t) and TFL values.
Regulation (values) of ECT associated with agonist
20) Confidence 0.02 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC137595 Disease Relevance 0 Pain Relevance 0.35

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