INT105751

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Context Info
Confidence 0.03
First Reported 2002
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 3.03
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasmic membrane-bounded vesicle (RFFL) ligase activity (RFFL) cytoplasm (RFFL)
Anatomy Link Frequency
cleavage 1
RFFL (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 8 99.22 Very High Very High Very High
qutenza 8 96.96 Very High Very High Very High
palliative 1 89.16 High High
Inflammatory response 1 64.28 Quite High
Inflammation 2 55.92 Quite High
Trigeminal ganglion neurons 1 53.64 Quite High
ischemia 22 40.72 Quite Low
Angina 8 5.00 Very Low Very Low Very Low
adenocard 6 5.00 Very Low Very Low Very Low
Kinase C 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 69 100.00 Very High Very High Very High
Injury 7 99.96 Very High Very High Very High
Prostate Cancer 11 99.92 Very High Very High Very High
Death 13 96.08 Very High Very High Very High
Cancer 6 78.32 Quite High
Neurodegenerative Disease 2 75.00 Quite High
INFLAMMATION 3 63.92 Quite High
Suicidal Behaviour 1 62.72 Quite High
Ganglion Cysts 1 53.32 Quite High
Necrosis 9 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All caspases are synthesized as zymogens that contain a prodomain, a large subunit and a small subunit, and activation of these enzymes is by proteolytic cleavage.
Gene_expression (synthesized) of caspases in cleavage
1) Confidence 0.03 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291307 Disease Relevance 0.98 Pain Relevance 0.06
Expression of key regulators of the apoptotic pathway such as bcl-2 and caspases within individual prostate tumors appear to correlate with the prostate cancer cell's sensitivity to traditional therapeutic modalities, including androgen ablation and radiotherapy.
Gene_expression (Expression) of caspases associated with prostate cancer and apoptosis
2) Confidence 0.02 Published 2002 Journal Oncol. Rep. Section Abstract Doc Link 12375010 Disease Relevance 1.41 Pain Relevance 0.09
Comparison of two adjacent sections immunostained for the two different antigens revealed the co-expression of the two caspases.
Gene_expression (co-expression) of caspases
3) Confidence 0.00 Published 2005 Journal Arch. Histol. Cytol. Section Abstract Doc Link 16477149 Disease Relevance 0.13 Pain Relevance 0.47
Involvement of mitochondria in acetaminophen-induced apoptosis and hepatic injury: roles of cytochrome c, Bax, Bid, and caspases.
Gene_expression (roles) of caspases associated with paracetamol, injury and apoptosis
4) Confidence 0.00 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Title Doc Link 12946648 Disease Relevance 0.52 Pain Relevance 0.62

General Comments

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