INT105754

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Context Info
Confidence 0.28
First Reported 2002
Last Reported 2010
Negated 4
Speculated 1
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 0.75
Pain Relevance 11.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (St13) protein folding (St13) cytosol (St13)
protein complex (St13) cytoplasm (St13)
Anatomy Link Frequency
neurons 1
Body 1
St13 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 17 100.00 Very High Very High Very High
Morphine 12 100.00 Very High Very High Very High
Potency 3 100.00 Very High Very High Very High
Antinociceptive 13 99.98 Very High Very High Very High
Opioid 32 99.88 Very High Very High Very High
Oxycodone 16 99.40 Very High Very High Very High
Dopamine 23 99.32 Very High Very High Very High
tolerance 10 98.78 Very High Very High Very High
antagonist 15 98.56 Very High Very High Very High
Dextromethorphan 10 98.38 Very High Very High Very High
Disease Link Frequency Relevance Heat
Gliosis 1 95.76 Very High Very High Very High
Parkinson's Disease 17 88.12 High High
Disease 7 75.76 Quite High
Pain 2 75.00 Quite High
Nociception 1 75.00 Quite High
Anxiety Disorder 2 71.92 Quite High
Loss Of Sense Of Smell 1 70.32 Quite High
Opiate Addiction 2 61.72 Quite High
Targeted Disruption 23 56.56 Quite High
Infection 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After 2 months, TH, DA, DOPAC, and reactive glia in the SNc were still altered in MPTPp-treated mice as compared to controls.
Regulation (altered) of SNc associated with dopamine
1) Confidence 0.28 Published 2009 Journal Neurotox Res Section Abstract Doc Link 19526289 Disease Relevance 0.40 Pain Relevance 0.30
Dextromethorphan produced lower ED(50) values for morphine, fentanyl and sufentanil but exerted no effect on the potency of SNC80 or U50,488H.
Neg (no) Regulation (effect) of SNC80 associated with dextromethorphan, potency and morphine
2) Confidence 0.18 Published 2002 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 12376154 Disease Relevance 0.07 Pain Relevance 1.78
Body temperature decreased with DAMGO, SNC80, U50,488H, and oxycodone; tolerance did not develop to hypothermic effect and BMS182874 did not affect DAMGO, SNC80, U50,488H, or oxycodone induced changes in body temperature.
Neg (not) Regulation (affect) of SNC80 in Body associated with oxycodone and tolerance
3) Confidence 0.14 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20303944 Disease Relevance 0 Pain Relevance 2.37
An administration of opioids that act on the different subtype receptors morphine, U50 and SNC80, induced a dose dependent decrease in both the rearing and climbing activity, meaning no behavioral dissociation.
Regulation (act) of SNC80 associated with opioid and morphine
4) Confidence 0.07 Published 2006 Journal Behav. Brain Res. Section Abstract Doc Link 16574254 Disease Relevance 0.06 Pain Relevance 1.12
Antinociceptive response of DAMGO, SNC80, U50,488H, and oxycodone in tolerant mice treated with BMS182874 was significantly higher (44.55%, 37.48%, 43.02%, and 56.08%, respectively) compared to tolerant mice treated with vehicle.
Regulation (response) of SNC80 associated with oxycodone and antinociceptive
5) Confidence 0.06 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20303944 Disease Relevance 0 Pain Relevance 2.32
Naloxone was found to have an antagonistic effect on morphine and U50-488H (micro and kappa subtype receptors, respectively), but no antagonistic effect on the delta subtype receptor agonist, SNC80.
Neg (no) Regulation (effect) of SNC80 associated with agonist, narcan and morphine
6) Confidence 0.06 Published 2006 Journal Behav. Brain Res. Section Abstract Doc Link 16574254 Disease Relevance 0.07 Pain Relevance 1.11
Dextromethorphan produced lower ED50 values for morphine, fentanyl and sufentanil but exerted no effect on SNC80 or U50,488H.
Neg (no) Regulation (effect) of SNC80 associated with dextromethorphan and morphine
7) Confidence 0.05 Published 2002 Journal Acta Anaesthesiol Belg Section Abstract Doc Link 12461830 Disease Relevance 0.07 Pain Relevance 2.31
To quantify the effect of hCAR expression on the transduction of the dopamine cells, we instead examined the anterograde labeling of dopaminergic axons in the dorsolateral striatum, the primary target of the SNc neurons [28], [29], [30].
Spec (examined) Regulation (target) of SNc in neurons associated with dopamine
8) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941453 Disease Relevance 0.06 Pain Relevance 0.12

General Comments

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