INT105760

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Context Info
Confidence 0.58
First Reported 2002
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.93
Pain Relevance 2.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Casr) plasma membrane (Casr) signal transducer activity (Casr)
Anatomy Link Frequency
CAR 3
thyroid 1
Casr (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 3 99.98 Very High Very High Very High
Dopamine 4 99.74 Very High Very High Very High
Paracetamol 11 99.56 Very High Very High Very High
agonist 5 98.28 Very High Very High Very High
Morphine 7 96.12 Very High Very High Very High
Opioid 1 79.08 Quite High
tolerance 1 62.80 Quite High
Pain 1 62.40 Quite High
cocaine 2 58.32 Quite High
fortral 6 57.84 Quite High
Disease Link Frequency Relevance Heat
Toxicity 1 99.92 Very High Very High Very High
Hepatotoxicity 7 95.40 Very High Very High Very High
Repression 2 94.08 High High
Targeted Disruption 4 76.80 Quite High
Attention Deficit Hyperactivity Disorder 1 65.04 Quite High
Pain 1 62.40 Quite High
Psychosis 1 62.04 Quite High
Adhesions 10 43.96 Quite Low
Cancer 2 42.16 Quite Low
Metastasis 2 19.60 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of CAR activity by administration of the inverse agonist ligand androstanol 1 hour after acetaminophen treatment blocked hepatotoxicity in wild type but not in CAR null mice.
Negative_regulation (Inhibition) of CAR in CAR associated with paracetamol, agonist and hepatotoxicity
1) Confidence 0.58 Published 2002 Journal Science Section Abstract Doc Link 12376703 Disease Relevance 0.36 Pain Relevance 0.68
In support of this idea, DN1, a fragment of ASC-2 encompassing the first LXXLL motif, suppressed CAR transactivation, and coexpressed ASC-2 but not other LXXLL-type coactivators such as thyroid hormone receptor-associated protein 220 reversed this repression.
Negative_regulation (suppressed) of CAR in thyroid associated with repression
2) Confidence 0.40 Published 2005 Journal Mol. Endocrinol. Section Abstract Doc Link 15764585 Disease Relevance 0.38 Pain Relevance 0.24
In contrast, CAR transactivation was significantly impaired in HepG2 cells stably expressing specific small interfering RNA directed against ASC-2.
Negative_regulation (impaired) of CAR in CAR
3) Confidence 0.40 Published 2005 Journal Mol. Endocrinol. Section Abstract Doc Link 15764585 Disease Relevance 0 Pain Relevance 0.07
All DA antagonists impaired CAR in the acquisition phase but only haloperidol disrupted performance.
Negative_regulation (impaired) of CAR in CAR associated with dopamine and antagonist
4) Confidence 0.38 Published 2004 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 14751417 Disease Relevance 0 Pain Relevance 0.97
Inhibition of AP-1 expression through suppression of the extracellular receptor kinase (ERK) MAPK pathway activity resulted in significant downregulation of the total level of sigma-1 receptors[14].
Negative_regulation (suppression) of extracellular receptor kinase
5) Confidence 0.01 Published 2007 Journal J Mol Signal Section Body Doc Link PMC2045653 Disease Relevance 0.19 Pain Relevance 0.21

General Comments

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