INT105761

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Context Info
Confidence 0.36
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 14.94
Pain Relevance 2.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GFAP) extracellular matrix organization (GFAP) cytoplasm (GFAP)
Anatomy Link Frequency
spinal cord 2
plaques 2
glial cell 1
epithelial cells 1
GFAP (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 21 99.42 Very High Very High Very High
Hippocampus 26 93.84 High High
Neuritis 2 91.20 High High
Central nervous system 7 90.48 High High
allodynia 12 88.56 High High
headache 5 88.12 High High
imagery 32 86.80 High High
Peripheral nerve injury 2 75.00 Quite High
Lasting pain 2 69.00 Quite High
cytokine 16 67.08 Quite High
Disease Link Frequency Relevance Heat
Ependymoma 113 99.98 Very High Very High Very High
Cancer 164 99.82 Very High Very High Very High
Amyloid Plaque 20 99.76 Very High Very High Very High
Carcinoma 44 98.90 Very High Very High Very High
Pinealoma 3 98.46 Very High Very High Very High
Glioblastoma 33 97.36 Very High Very High Very High
Chordoma 27 96.88 Very High Very High Very High
Exencephaly /

Neural Tube Defects

64 96.12 Very High Very High Very High
Rhinitis 4 95.48 Very High Very High Very High
Ganglion Cysts 4 95.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Histologically, the tumor was focally characterized by prominent perinecrotic pseudopalisading and demonstrated immunoreactivity with antibodies to cytokeratin AE1/3 and CAM5.2; the tumor did not stain with glial fibrillary acidic protein antibody.
glial fibrillary acidic protein Neg (not) Binding (stain) of associated with cancer
1) Confidence 0.36 Published 2002 Journal Ann Diagn Pathol Section Abstract Doc Link 12376923 Disease Relevance 1.30 Pain Relevance 0.13
It is well known that MPE stain positive with GFAP and S-100 protein.
GFAP Binding (stain) of associated with ependymoma
2) Confidence 0.36 Published 2008 Journal Diagn Pathol Section Body Doc Link PMC2584038 Disease Relevance 1.37 Pain Relevance 0.06
Immunohistochemically, the neoplastic cells showed strong, diffuse positive reaction with S-100 protein (figure 4a) and glial fibrillary acidic protein (GFAP) (figure 4b), indicating the glial nature of the lesion.
GFAP Binding (reaction) of
3) Confidence 0.36 Published 2008 Journal Diagn Pathol Section Body Doc Link PMC2584038 Disease Relevance 1.16 Pain Relevance 0.10
The cystic epithelial cells typically stain negatively for glial fibrillary acidic protein (GFAP) and positively for cytokeratin, epithelial membrane antigen, and carcinoembryonic antigen (CEA) on immunohistochemical assays.
GFAP Binding (cytokeratin) of in epithelial cells
4) Confidence 0.36 Published 2010 Journal Journal of Craniovertebral Junction and Spine Section Body Doc Link PMC2944853 Disease Relevance 0.43 Pain Relevance 0
In addition SNP caused an elevation of glial cell response mRNAs primarily associated with Müller cells (GFAP, CNTF, bFGF) as well as caspase-3 and Bcl-2.
GFAP Binding (associated) of in glial cell
5) Confidence 0.36 Published 2007 Journal Brain Res. Bull. Section Abstract Doc Link 17562394 Disease Relevance 0.52 Pain Relevance 0
Both cells showed strong stainability with glial fibrillary acidic protein (GFAP) and S-100 protein immunohistochemically, so that the tumor was classified as adenoid glioblastoma.
GFAP Binding (stainability) of associated with glioblastoma and cancer
6) Confidence 0.36 Published 2005 Journal Pathol. Int. Section Abstract Doc Link 15943792 Disease Relevance 1.76 Pain Relevance 0.08
Histologically, the tumor was composed of two areas, a main area of large neoplastic cells with pleomorphic atypical nuclei and abundant cytoplasm, which by immunohistochemistry was reactive for glial fibrillary acidic protein, mixed with several foci of poorly differentiated tumoral cells with elongated nuclei and scant cytoplasm, negative for GFAP, but robustly immunoreactive for synaptophysin and phosphoneurofilaments.
GFAP Binding (negative) of associated with cancer
7) Confidence 0.35 Published 2006 Journal Acta Neuropathol. Section Abstract Doc Link 16557392 Disease Relevance 1.13 Pain Relevance 0.08
Although, metastatic carcinomas are positive for cytokeratins, these are consistently negative for GFAP.
GFAP Binding (negative) of associated with carcinoma
8) Confidence 0.35 Published 2008 Journal Diagn Pathol Section Body Doc Link PMC2584038 Disease Relevance 2.12 Pain Relevance 0
On day 28 or 42 (after a 14-day drug washout period), lumbar spinal cord sections were processed for assessment of astrocytic glial fibrillary acidic protein (GFAP) and microglial OX-42 (antibody against CR3/CD11b).
acidic protein Binding (assessment) of in spinal cord associated with spinal cord
9) Confidence 0.30 Published 2007 Journal Brain Behav. Immun. Section Abstract Doc Link 17544848 Disease Relevance 0.79 Pain Relevance 0.60
On day 28 or 42 (after a 14-day drug washout period), lumbar spinal cord sections were processed for assessment of astrocytic glial fibrillary acidic protein (GFAP) and microglial OX-42 (antibody against CR3/CD11b).
acidic protein Binding (assessment) of in spinal cord associated with spinal cord
10) Confidence 0.30 Published 2007 Journal Brain Behav. Immun. Section Abstract Doc Link 16949251 Disease Relevance 0.79 Pain Relevance 0.60
Histologically, papillary tumours of the pineal region are characterized by a papillary architecture and epithelial cytology, with immunoreactivity for cytokeratin and, focally, GFAP.
GFAP Binding (immunoreactivity) of associated with pinealoma
11) Confidence 0.25 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC1929165 Disease Relevance 0.97 Pain Relevance 0.07
It has been established that the number of GFAP-positive astrocytes associated with amyloid plaques changes during plaque formation.
GFAP-positive Binding (associated) of in plaques associated with amyloid plaque
12) Confidence 0.07 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1613236 Disease Relevance 1.20 Pain Relevance 0.30
There are fewer GFAP-positive astrocytes associated with diffuse plaques; while more are associated with neuritic plaques containing fibrillar A?
GFAP-positive Binding (associated) of in plaques associated with amyloid plaque
13) Confidence 0.06 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1613236 Disease Relevance 1.12 Pain Relevance 0.30

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