INT105774

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Context Info
Confidence 0.42
First Reported 2002
Last Reported 2008
Negated 2
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.40
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pde4a) nucleus (Pde4a) cytoplasm (Pde4a)
Anatomy Link Frequency
hippocampus 3
cerebral cortex 1
Pde4a (Mus musculus)
Pain Link Frequency Relevance Heat
cerebral cortex 2 100.00 Very High Very High Very High
Hippocampus 2 100.00 Very High Very High Very High
antidepressant 12 93.76 High High
adenocard 4 90.60 High High
isoflurane 3 78.48 Quite High
anesthesia 1 77.28 Quite High
Desipramine 2 72.24 Quite High
fluoxetine 2 70.96 Quite High
depression 2 25.00 Low Low
agonist 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 4 100.00 Very High Very High Very High
Apoptosis 2 5.00 Very Low Very Low Very Low
Hypertrophy 2 5.00 Very Low Very Low Very Low
Depression 2 5.00 Very Low Very Low Very Low
Myocardial Infarction 2 5.00 Very Low Very Low Very Low
Adenovirus Infection 1 5.00 Very Low Very Low Very Low
Dilated Cardiomyopathy 1 5.00 Very Low Very Low Very Low
Stress 1 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, immunoblot analysis showed loss of phosphodiesterase 4D (PDE4D) expression in the cerebral cortex and hippocampus of PDE4D knockout (PDE4D-/-) mice, but unchanged PDE4A and PDE4B expression, relative to the wild type (PDE4D+/+) and heterozygous knockout (PDE4D+/-) mice.
Negative_regulation (loss) of Neg (unchanged) Gene_expression (expression) of PDE4A in hippocampus associated with targeted disruption, hippocampus and cerebral cortex
1) Confidence 0.42 Published 2002 Journal Neuropsychopharmacology Section Abstract Doc Link 12377395 Disease Relevance 0.20 Pain Relevance 0.44
PDE4 and PDE3 activity are defined as the PDE activity inhibited by the PDE4-selective inhibitor, Rolipram (10 ?
Negative_regulation (defined) of Gene_expression (activity) of PDE4
2) Confidence 0.33 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0 Pain Relevance 0.15
In the present study, immunoblot analysis showed loss of phosphodiesterase 4D (PDE4D) expression in the cerebral cortex and hippocampus of PDE4D knockout (PDE4D-/-) mice, but unchanged PDE4A and PDE4B expression, relative to the wild type (PDE4D+/+) and heterozygous knockout (PDE4D+/-) mice.
Negative_regulation (loss) of in cerebral cortex Neg (unchanged) Gene_expression (expression) of PDE4A in hippocampus associated with targeted disruption, hippocampus and cerebral cortex
3) Confidence 0.14 Published 2002 Journal Neuropsychopharmacology Section Abstract Doc Link 12377395 Disease Relevance 0.20 Pain Relevance 0.44

General Comments

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