INT105775

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Context Info
Confidence 0.78
First Reported 2002
Last Reported 2009
Negated 1
Speculated 1
Reported most in Body
Documents 31
Total Number 32
Disease Relevance 4.18
Pain Relevance 5.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pde4d) Golgi apparatus (Pde4d) plasma membrane (Pde4d)
cytoskeleton (Pde4d) cytoplasm (Pde4d)
Anatomy Link Frequency
hippocampus 4
cerebral cortex 2
lung 2
cardiomyocytes 1
brain 1
Pde4d (Mus musculus)
Pain Link Frequency Relevance Heat
cerebral cortex 10 99.68 Very High Very High Very High
Inflammation 155 99.32 Very High Very High Very High
fluoxetine 6 99.22 Very High Very High Very High
Desipramine 8 98.92 Very High Very High Very High
Hippocampus 21 98.88 Very High Very High Very High
antidepressant 42 98.68 Very High Very High Very High
agonist 240 97.48 Very High Very High Very High
Inflammatory response 20 96.08 Very High Very High Very High
adenocard 9 90.28 High High
addiction 22 84.76 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 165 99.32 Very High Very High Very High
Pneumonia 35 98.60 Very High Very High Very High
Targeted Disruption 48 98.04 Very High Very High Very High
Disease 17 96.96 Very High Very High Very High
Pulmonary Disease 95 95.56 Very High Very High Very High
Schizophrenia 6 91.80 High High
Cognitive Disorder 94 73.76 Quite High
Emphysema 15 65.64 Quite High
Vomiting 19 63.60 Quite High
Headache 7 61.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, immunoblot analysis showed loss of phosphodiesterase 4D (PDE4D) expression in the cerebral cortex and hippocampus of PDE4D knockout (PDE4D-/-) mice, but unchanged PDE4A and PDE4B expression, relative to the wild type (PDE4D+/+) and heterozygous knockout (PDE4D+/-) mice.
Gene_expression (expression) of PDE4D in hippocampus associated with targeted disruption, hippocampus and cerebral cortex
1) Confidence 0.78 Published 2002 Journal Neuropsychopharmacology Section Abstract Doc Link 12377395 Disease Relevance 0.19 Pain Relevance 0.38
In the present study, immunoblot analysis showed loss of phosphodiesterase 4D (PDE4D) expression in the cerebral cortex and hippocampus of PDE4D knockout (PDE4D-/-) mice, but unchanged PDE4A and PDE4B expression, relative to the wild type (PDE4D+/+) and heterozygous knockout (PDE4D+/-) mice.
Gene_expression (expression) of phosphodiesterase 4D in hippocampus associated with targeted disruption, hippocampus and cerebral cortex
2) Confidence 0.78 Published 2002 Journal Neuropsychopharmacology Section Abstract Doc Link 12377395 Disease Relevance 0.19 Pain Relevance 0.38
Three PDE4 subtypes, PDE4A, PDE4B, and PDE4D, are expressed in neonatal cardiomyocytes at comparable levels (Figure 2B).
Gene_expression (expressed) of PDE4D in cardiomyocytes
3) Confidence 0.76 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0 Pain Relevance 0
1AR/PDE4D dissociation is not complete and some portion of receptor/PDE complexes (?
Gene_expression (dissociation) of PDE4D
4) Confidence 0.66 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0 Pain Relevance 0.16
PDE4D ablation promotes ?
Gene_expression (ablation) of PDE4D
5) Confidence 0.66 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0 Pain Relevance 0.11
1AR/PDE4D complex (Figure 4A and B), whereas the stereoisomer, (+)-norepinephrine, which is a poor ?
Gene_expression (complex) of PDE4D
6) Confidence 0.66 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0 Pain Relevance 0.12
Thus, under basal conditions, PDE4D is poised to control local cAMP concentration and PKA activity in the vicinity of the ?
Gene_expression (poised) of PDE4D
7) Confidence 0.66 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0 Pain Relevance 0.12
Importantly, upon stimulation with the adenylyl cyclase activator, Forskolin, all PDE4D isoforms show the same increase in activity in both cell types (Figure 5C), suggesting that loss of one ?
Gene_expression (isoforms) of PDE4D
8) Confidence 0.66 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0 Pain Relevance 0.03
Although additional steps in excitation contraction coupling may also be affected by the absence of PDE4D, this observation is consistent with the idea that a major function of PDE4D in the ?
Gene_expression (function) of PDE4D
9) Confidence 0.66 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0 Pain Relevance 0
Thus, PDE4D is the endogenous PDE recovered in complex with the receptor.
Gene_expression (recovered) of PDE4D
10) Confidence 0.66 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0 Pain Relevance 0
2AR, PDE4D8 was the PDE4D isoform predominantly activated after stimulation of ?
Gene_expression (was) of PDE4D isoform
11) Confidence 0.66 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0 Pain Relevance 0.07
2AR, PDE4D8 was the PDE4D isoform predominantly activated after stimulation of ?
Gene_expression (was) of PDE4D8
12) Confidence 0.66 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0 Pain Relevance 0.10
-arrestin-deficient MEFs (Supplementary Figures 3 and 4) and occurred whether the overexpressed PDE4D was catalytically active or inactive (Supplementary Figure 5).
Spec (whether) Gene_expression (overexpressed) of PDE4D
13) Confidence 0.66 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0 Pain Relevance 0.15
Although additional steps in excitation contraction coupling may also be affected by the absence of PDE4D, this observation is consistent with the idea that a major function of PDE4D in the ?
Neg (absence) Gene_expression (absence) of PDE4D
14) Confidence 0.66 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0 Pain Relevance 0
-adrenergic stimulation as a read-out, we show here that PDE4D deficiency promotes an accelerated desensitization of ?
Gene_expression (deficiency) of PDE4D
15) Confidence 0.66 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0 Pain Relevance 0
The selective activation of PDE4D splicing variants by ?
Gene_expression (splicing) of PDE4D
16) Confidence 0.66 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0 Pain Relevance 0.03
Consistent with this idea, we report here that PDE4D deficiency accelerates the desensitization of ?
Gene_expression (deficiency) of PDE4D
17) Confidence 0.66 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0 Pain Relevance 0
In mouse hippocampus and cerebral cortex, the effects of repeated treatment with the antidepressants desipramine and fluoxetine or the PDE4 inhibitor rolipram on the expression of PDE4D was compared to that of PDE4A and PDE4B, the other two subtypes expressed in the brain.
Gene_expression (expression) of PDE4D in brain associated with desipramine, antidepressant, hippocampus, cerebral cortex and fluoxetine
18) Confidence 0.65 Published 2006 Journal Brain Res. Section Abstract Doc Link 16730340 Disease Relevance 0 Pain Relevance 0.68
Expression of PDE4D was increased by all drugs tested, with the exception of desipramine in hippocampus.
Gene_expression (Expression) of PDE4D in hippocampus associated with desipramine and hippocampus
19) Confidence 0.65 Published 2006 Journal Brain Res. Section Abstract Doc Link 16730340 Disease Relevance 0 Pain Relevance 0.72
We next wanted to determine whether inhibition of PDE4B, PDE4D and PDE7A expression in the lung would protect against lung inflammation in mice exposed to cigarette smoke.
Gene_expression (expression) of PDE4D in lung associated with inflammation and pneumonia
20) Confidence 0.60 Published 2009 Journal Respir Res Section Body Doc Link PMC2696437 Disease Relevance 0.66 Pain Relevance 0.22

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