INT105777

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Context Info
Confidence 0.76
First Reported 2002
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 30
Total Number 33
Disease Relevance 12.67
Pain Relevance 8.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pde4a) nucleus (Pde4a) cytoplasm (Pde4a)
Anatomy Link Frequency
brain 4
cardiomyocytes 3
hippocampus 2
neurons 2
lung 2
Pde4a (Mus musculus)
Pain Link Frequency Relevance Heat
antidepressant 59 99.96 Very High Very High Very High
Hippocampus 74 99.68 Very High Very High Very High
Inflammatory marker 6 99.64 Very High Very High Very High
Inflammatory response 52 99.60 Very High Very High Very High
Inflammation 514 99.48 Very High Very High Very High
Inflammatory stimuli 3 99.40 Very High Very High Very High
rheumatoid arthritis 39 99.16 Very High Very High Very High
adenocard 32 99.00 Very High Very High Very High
cerebral cortex 12 98.68 Very High Very High Very High
fibrosis 158 98.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pulmonary Disease 552 100.00 Very High Very High Very High
INFLAMMATION 553 99.64 Very High Very High Very High
Schizophrenia 36 99.40 Very High Very High Very High
Targeted Disruption 98 99.36 Very High Very High Very High
Rheumatoid Arthritis 39 99.16 Very High Very High Very High
Vomiting 90 99.12 Very High Very High Very High
Adhesions 8 98.64 Very High Very High Very High
Pulmonary Fibrosis 84 98.60 Very High Very High Very High
Cognitive Disorder 564 98.08 Very High Very High Very High
Headache 17 97.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By contrast, these treatments affected PDE4A and PDE4B expression differentially.
Gene_expression (expression) of PDE4A
1) Confidence 0.76 Published 2006 Journal Brain Res. Section Abstract Doc Link 16730340 Disease Relevance 0 Pain Relevance 0.76
Regulation of phosphodiesterase-4 (PDE4) expression in mouse brain by repeated antidepressant treatment: comparison with rolipram.
Gene_expression (expression) of PDE4 in brain associated with antidepressant
2) Confidence 0.76 Published 2006 Journal Brain Res. Section Title Doc Link 16730340 Disease Relevance 0 Pain Relevance 0.61
In mouse hippocampus and cerebral cortex, the effects of repeated treatment with the antidepressants desipramine and fluoxetine or the PDE4 inhibitor rolipram on the expression of PDE4D was compared to that of PDE4A and PDE4B, the other two subtypes expressed in the brain.
Gene_expression (expressed) of PDE4A in brain associated with desipramine, antidepressant, hippocampus, cerebral cortex and fluoxetine
3) Confidence 0.76 Published 2006 Journal Brain Res. Section Abstract Doc Link 16730340 Disease Relevance 0 Pain Relevance 0.72
These results indicate that elevation of cAMP in neurons that express PDE4s may attenuate the rewarding properties of cocaine and morphine, but does not alter the cocaine signalling cascade that induces c-Fos expression.
Gene_expression (express) of PDE4s in neurons associated with morphine and cocaine
4) Confidence 0.64 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15128409 Disease Relevance 0 Pain Relevance 0.86
Three PDE4 subtypes, PDE4A, PDE4B, and PDE4D, are expressed in neonatal cardiomyocytes at comparable levels (Figure 2B).
Gene_expression (expressed) of PDE4 in cardiomyocytes
5) Confidence 0.60 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0 Pain Relevance 0
Pharmacological inhibition of type 4 cyclic adenosine monophosphate (cAMP)-specific phosphodiesterase (PDE4) produces antidepressant-like effects in animals; however, it is not known which of the four PDE4 subtypes mediates these actions.
Gene_expression (produces) of PDE4 associated with antidepressant and adenocard
6) Confidence 0.58 Published 2002 Journal Neuropsychopharmacology Section Abstract Doc Link 12377395 Disease Relevance 0.15 Pain Relevance 0.22
In the present study, immunoblot analysis showed loss of phosphodiesterase 4D (PDE4D) expression in the cerebral cortex and hippocampus of PDE4D knockout (PDE4D-/-) mice, but unchanged PDE4A and PDE4B expression, relative to the wild type (PDE4D+/+) and heterozygous knockout (PDE4D+/-) mice.
Neg (unchanged) Gene_expression (expression) of PDE4A in hippocampus associated with targeted disruption, hippocampus and cerebral cortex
7) Confidence 0.58 Published 2002 Journal Neuropsychopharmacology Section Abstract Doc Link 12377395 Disease Relevance 0.20 Pain Relevance 0.43
Degradation of cAMP occurs through the action of phosphodiesterases, such as the Type IV phosphodiesterases (PDE4s) that are found throughout the brain.
Gene_expression (found) of PDE4s in brain
8) Confidence 0.55 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15128409 Disease Relevance 0 Pain Relevance 0.45
Three PDE4 subtypes, PDE4A, PDE4B, and PDE4D, are expressed in neonatal cardiomyocytes at comparable levels (Figure 2B).
Gene_expression (expressed) of PDE4A in cardiomyocytes
9) Confidence 0.52 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0 Pain Relevance 0
To assess which of the PDE4 subtypes contribute to the activity recovered in the ?
Gene_expression (recovered) of PDE4
10) Confidence 0.52 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0 Pain Relevance 0
To assess which of the PDE4 subtypes contribute to the activity recovered in the ?
Gene_expression (subtypes) of PDE4
11) Confidence 0.52 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0 Pain Relevance 0
IP of PDE4 subtypes and splice variants from cell extracts
Gene_expression (subtypes) of PDE4
12) Confidence 0.52 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0 Pain Relevance 0
PDE4 and PDE3 activity are defined as the PDE activity inhibited by the PDE4-selective inhibitor, Rolipram (10 ?
Gene_expression (activity) of PDE4
13) Confidence 0.52 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0 Pain Relevance 0.15
PAN-selective antibodies against PDE4A (AC55), PDE4B (K118), and PDE4D (M3S1), as well as splice variant-selective antibodies against PDE4D3, 4, 5, 8, and 9 (Richter et al, 2005), were used in IPs to determine the expression of the respective PDE4 subtype and splice variant in cardiac myocytes (Figure 2), as well as their PKA-dependent activation after ?
Spec (determine) Gene_expression (expression) of PDE4 in cardiac myocytes
14) Confidence 0.47 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0.19 Pain Relevance 0
Furthermore, PDE 4 inhibitors produce marked anti-inflammatory actions in several animal models of allergic asthma [21,22,35].
Gene_expression (produce) of PDE 4 associated with asthma and inflammation
15) Confidence 0.44 Published 2004 Journal Respir Res Section Body Doc Link PMC419478 Disease Relevance 1.00 Pain Relevance 0.60
These results are consistent with the fact that PDE4 expression is induced by inflammatory stimulus and that it mediates activation and proliferation of T-cells and function of macrophages [25-28].
Gene_expression (expression) of PDE4 in macrophages associated with inflammatory stimuli
16) Confidence 0.36 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2881047 Disease Relevance 1.50 Pain Relevance 0.59
PDE4 is expressed in a wide variety of tissues, e.g., brain, lungs, and testes (Perez-Torres et al. 2000; Reyes-Irisarri et al. 2008; Richter et al. 2005; Salanova et al. 1999).
Gene_expression (expressed) of PDE4 in lungs
17) Confidence 0.32 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2704616 Disease Relevance 0 Pain Relevance 0.03
In contrast, PDE4 is highly expressed in the hippocampus and cortex (Perez-Torres et al. 2000) and is, therefore, considered a better target for cognition enhancement.
Gene_expression (expressed) of PDE4 in cortex associated with cognitive disorder and hippocampus
18) Confidence 0.32 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2704616 Disease Relevance 0.82 Pain Relevance 0.05
Effect of PDE4 inhibition on lung inflammatory markers
Gene_expression (inhibition) of PDE4 in lung associated with inflammatory marker
19) Confidence 0.31 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2881047 Disease Relevance 0.52 Pain Relevance 0.26
Moreover, it was shown that PDE4 itself is necessary for TNF-?
Gene_expression (itself) of PDE4
20) Confidence 0.31 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2881047 Disease Relevance 0.76 Pain Relevance 0.34

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