INT10578

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Context Info
Confidence 0.53
First Reported 1992
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.84
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cyp11a1)
Anatomy Link Frequency
adrenal glands 1
skin 1
PVN 1
Cyp11a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 6 99.92 Very High Very High Very High
Dorsal horn 8 98.84 Very High Very High Very High
Sciatic nerve 1 96.08 Very High Very High Very High
Pain 4 95.04 Very High Very High Very High
dexamethasone 2 75.00 Quite High
anesthesia 4 65.60 Quite High
halothane 2 65.16 Quite High
Lasting pain 1 51.12 Quite High
Neuropathic pain 1 32.48 Quite Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 5 98.60 Very High Very High Very High
Skin Cancer 12 97.44 Very High Very High Very High
Pain 4 95.04 Very High Very High Very High
Nociception 1 93.92 High High
Smith-lemli-opitz Syndrome 12 85.60 High High
Malignant Neoplastic Disease 4 51.20 Quite High
Apoptosis 1 37.28 Quite Low
Cancer 2 36.16 Quite Low
Death 1 36.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
P450scc mRNA concentration was threefold higher in the DH of neuropathic rats than in controls.
Transcription (concentration) of P450scc associated with neuropathic pain and dorsal horn
1) Confidence 0.53 Published 2006 Journal J. Mol. Neurosci. Section Abstract Doc Link 16632873 Disease Relevance 0.61 Pain Relevance 0.76
These results further strengthen our proposal that in vivo sequential metabolism of 7DHC in adrenal glands is initiated by P450scc, involves 3?
Transcription (initiated) of P450scc in adrenal glands
2) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2629546 Disease Relevance 0.09 Pain Relevance 0
Since the activity of P450scc is low in skin [10] (too low to detect ex-vivo production of 7DHP by above methods), we isolated mitochondria from rat skin to test 7DHC metabolism.
Transcription (activity) of P450scc in skin
3) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2629546 Disease Relevance 0.15 Pain Relevance 0
Placement of DEX adjacent to the fetal PVN prevented reemergence of expression of mRNA for P450(17)alpha and P450scc at 126-128 dGA, but had no effect on mRNA for P450C21 or P45011 beta.
Transcription (expression) of P450scc in PVN
4) Confidence 0.07 Published 1992 Journal Endocrinology Section Abstract Doc Link 1505467 Disease Relevance 0 Pain Relevance 0.17

General Comments

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