INT105783

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Context Info
Confidence 0.48
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 4.72
Pain Relevance 2.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL6) aging (IL6) extracellular region (IL6)
Anatomy Link Frequency
macrophage 1
spinal cord 1
nerve 1
fibroblast 1
T cells 1
IL6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 59 100.00 Very High Very High Very High
cytokine 46 100.00 Very High Very High Very High
chemokine 2 99.82 Very High Very High Very High
metalloproteinase 9 98.72 Very High Very High Very High
Sciatica 12 98.16 Very High Very High Very High
Spinal cord 2 96.48 Very High Very High Very High
Arthritis 105 92.44 High High
pulpitis 1 91.80 High High
fibrosis 2 91.08 High High
Myofascial pain syndrome 4 82.72 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 59 100.00 Very High Very High Very High
Necrosis 7 99.32 Very High Very High Very High
Cancer 155 99.14 Very High Very High Very High
Nerve Root Compression 8 98.16 Very High Very High Very High
Spinal Cord Diseases 8 96.08 Very High Very High Very High
Disease 31 92.88 High High
Seronegative Spondarthritis 92 92.44 High High
Pulpitis 1 91.80 High High
Fibrosis 2 91.08 High High
Epstein-barr Virus 1 90.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results show that the cellular response detected by transcriptional changes of NLR expression in HCE-T cells is accompanied by the enhanced secretion of the pro-inflammatory cytokine, IL-6, but not that of the biologically active IL-1?
Protein_catabolism (pro-inflammatory) of IL-6 in T cells associated with inflammation and cytokine
1) Confidence 0.48 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0.16 Pain Relevance 0.26
The concentration of IL-6 was significantly higher in Groups M and R than in the control, possibly demonstrating spinal cord and nerve root damage, respectively.
Protein_catabolism (concentration) of IL-6 in nerve associated with spinal cord
2) Confidence 0.34 Published 2009 Journal Eur Spine J Section Abstract Doc Link 19543752 Disease Relevance 0.93 Pain Relevance 0.45
The effects of tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, and transforming growth factor-beta1 on pulp fibroblast mediated collagen degradation.
Protein_catabolism (degradation) of interleukin-6 in fibroblast associated with necrosis, cancer and cytokine
3) Confidence 0.28 Published 2006 Journal J Endod Section Title Doc Link 16934628 Disease Relevance 0.29 Pain Relevance 0.50
, a key proinflammatory cytokine, induces the production of other inflammatory cytokines such as IL-1, IL-6, and granulocyte-macrophage colony-stimulating factor, chemokines such as IL-6, degradative enzymes such as several matrix metalloproteinases (MMPs) and other factors.
Protein_catabolism (degradative) of IL-6 in macrophage associated with chemokine, inflammation, metalloproteinase and cytokine
4) Confidence 0.21 Published 2005 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1208938 Disease Relevance 0.97 Pain Relevance 0.66
The concentration of IL-6 was significantly higher in the patients with degenerative changes than in other patients (P<0.05).
Protein_catabolism (concentration) of IL-6
5) Confidence 0.17 Published 2002 Journal Br J Oral Maxillofac Surg Section Abstract Doc Link 12379189 Disease Relevance 0.43 Pain Relevance 0.50
B leading to transactivation of the IL-6 gene, and rapid degradation of let-7 miRNA, which is a direct inhibitor of IL-6 expression [271].
Protein_catabolism (degradation) of IL-6
6) Confidence 0.16 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 1.00 Pain Relevance 0.13
The concentration of IL-6 was significantly higher in Groups M and R than in the control, possibly demonstrating spinal cord and nerve root damage, respectively.
Protein_catabolism (concentration) of IL-6 in spinal cord associated with spinal cord
7) Confidence 0.11 Published 2009 Journal Eur Spine J Section Abstract Doc Link 19543752 Disease Relevance 0.93 Pain Relevance 0.45

General Comments

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