INT105794

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.54
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 8
Disease Relevance 1.55
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Aldh5a1) oxidoreductase activity (Aldh5a1)
Anatomy Link Frequency
amniotic fluid 1
Aldh5a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Neurotransmitter 28 98.72 Very High Very High Very High
gABA 357 96.88 Very High Very High Very High
imagery 23 79.20 Quite High
Glutamate 35 40.92 Quite Low
GABAergic 21 38.40 Quite Low
palliative 7 27.20 Quite Low
Enkephalin 1 25.00 Low Low
Substantia nigra 1 25.00 Low Low
Dopamine 1 25.00 Low Low
substance P 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Convulsion 63 98.60 Very High Very High Very High
Epilepsy 7 97.16 Very High Very High Very High
Encephalopathy 14 88.36 High High
Muscle Hypotonia 7 83.36 Quite High
Ataxia 7 82.48 Quite High
Poisoning 2 75.04 Quite High
Congenital Anomalies 42 57.12 Quite High
Dystonia 2 37.68 Quite Low
Hypokinesia 1 35.44 Quite Low
Stress 7 30.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data for DHHA, a species unique to Aldh5a1 deficiency, were also revealing.
Negative_regulation (deficiency) of Aldh5a1
1) Confidence 0.54 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2642797 Disease Relevance 0.06 Pain Relevance 0.03
Data on motor behavioural disorders induced by systemic 3-nitropropionic acid, an irreversible inhibitor of mitochondrial succinate dehydrogenase and their histopathological correlates in mice, are sparse.
Negative_regulation (inhibitor) of mitochondrial succinate dehydrogenase
2) Confidence 0.42 Published 2002 Journal Neuroscience Section Abstract Doc Link 12379255 Disease Relevance 0.15 Pain Relevance 0.04
A cardinal manifestation of SSADH deficiency is hyperintense signals in the globi pallidi bilaterally.
Negative_regulation (deficiency) of SSADH
3) Confidence 0.39 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2642797 Disease Relevance 0.07 Pain Relevance 0.15
Succinic semialdehyde dehydrogenase (SSADH) deficiency (aldehyde dehydrogenase 5a1 (Aldh5a1); E.C. 1.2.1.24; OMIM 271980, 610045) is a rare neurometabolic defect of the GABA catabolic pathway (Fig. 1).
Negative_regulation (deficiency) of Aldh5a1 associated with gaba
4) Confidence 0.39 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2642797 Disease Relevance 0.43 Pain Relevance 0.08
The same metabolites were quantified in amniotic fluid specimens submitted for prenatal diagnosis in pregnancies at-risk for Aldh5a1 deficiency.
Negative_regulation (deficiency) of Aldh5a1 in amniotic fluid
5) Confidence 0.39 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2642797 Disease Relevance 0 Pain Relevance 0.10
Neurotransmitter alterations in embryonic succinate semialdehyde dehydrogenase (SSADH) deficiency suggest a heightened excitatory state during development

Background

Negative_regulation (deficiency) of SSADH associated with neurotransmitter
6) Confidence 0.39 Published 2008 Journal BMC Dev Biol Section Title Doc Link PMC2642797 Disease Relevance 0.32 Pain Relevance 0.18
Succinic semialdehyde dehydrogenase (SSADH) deficiency (aldehyde dehydrogenase 5a1 (Aldh5a1); E.C. 1.2.1.24; OMIM 271980, 610045) is a rare neurometabolic defect of the GABA catabolic pathway (Fig. 1).
Negative_regulation (deficiency) of SSADH associated with gaba
7) Confidence 0.39 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2642797 Disease Relevance 0.42 Pain Relevance 0.08
We recently identified a 19 year-old patient with SSADH deficiency who, having experienced recurrent seizures for 6 years, died suddenly and unexpectedly [27].
Negative_regulation (deficiency) of SSADH associated with convulsion
8) Confidence 0.39 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2642797 Disease Relevance 0.10 Pain Relevance 0.14

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox