INT105815

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.50
First Reported 2002
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 3.62
Pain Relevance 1.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (P2RY2) aging (P2RY2) plasma membrane (P2RY2)
embryo development (P2RY2) lysosome (P2RY2) signal transducer activity (P2RY2)
Anatomy Link Frequency
blood vessels 2
14.1 2
peripheral nerve trunk 2
P2RY2 (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 31 100.00 Very High Very High Very High
antagonist 51 99.50 Very High Very High Very High
Pain 13 98.40 Very High Very High Very High
Neuropathic pain 2 96.80 Very High Very High Very High
Peripheral nervous system 1 91.32 High High
Opioid 1 88.76 High High
c fibre 1 87.76 High High
Inflammation 32 87.44 High High
Hyperalgesia 1 87.28 High High
Hippocampus 6 86.08 High High
Disease Link Frequency Relevance Heat
Injury 223 99.56 Very High Very High Very High
Stress 16 98.94 Very High Very High Very High
Pain 10 98.40 Very High Very High Very High
Neuropathic Pain 4 96.80 Very High Very High Very High
Nociception 8 94.08 High High
Wound Healing 115 92.88 High High
Cataract 5 87.84 High High
INFLAMMATION 32 87.44 High High
Hyperalgesia 1 87.28 High High
Targeted Disruption 15 85.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cells were transfected with 300 nM P2Y2-R siRNA #1, 300 nM P2Y2-R siRNA #2, or the transfection reagent alone (control) for 72 h and then processed for ICC.
Positive_regulation (transfected) of Gene_expression (transfected) of P2Y2-R
1) Confidence 0.50 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2695252 Disease Relevance 0.18 Pain Relevance 0.04
To know the role of rabbit P2Y2-R in Ap4A-re-epithelialization process, a migration assay was performed on cells transfected with P2Y2-R siRNA #1 and P2Y2-R siRNA #2.
Positive_regulation (transfected) of Gene_expression (transfected) of P2Y2-R
2) Confidence 0.50 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2695252 Disease Relevance 0.60 Pain Relevance 0
Cells were transfected with 300 nM P2Y2-R siRNA #1, 300 nM P2Y2-R siRNA #2, or the transfection reagent alone (control) for 72 h and then processed for ICC.
Positive_regulation (transfected) of Gene_expression (transfected) of P2Y2-R
3) Confidence 0.50 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2695252 Disease Relevance 0.18 Pain Relevance 0.04
The analysis for a longer period of time (36 h after the wound) demonstrated a full recovery of the P2Y2 signaling, similar to the control (1424.14±14.1; Figure 2D).
Positive_regulation (recovery) of Gene_expression (recovery) of P2Y2 in 14.1 associated with injury
4) Confidence 0.50 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2695252 Disease Relevance 0.51 Pain Relevance 0
To know the role of rabbit P2Y2-R in Ap4A-re-epithelialization process, a migration assay was performed on cells transfected with P2Y2-R siRNA #1 and P2Y2-R siRNA #2.
Positive_regulation (transfected) of Gene_expression (transfected) of P2Y2-R
5) Confidence 0.50 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2695252 Disease Relevance 0.60 Pain Relevance 0
Immunogold electron microscopic observations of HA-A1R and Myc-P2Y2R expressed in HEK293T cells
Positive_regulation (observations) of Gene_expression (expressed) of P2Y2R
6) Confidence 0.46 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC3009664 Disease Relevance 0 Pain Relevance 0.10
In intact human blood vessels examined in vitro, shear stress decreased contractile P2X1 receptor expression, but increased the expression of mitogenic P2Y2 and P2Y6 receptors in VSMC [151].
Positive_regulation (increased) of Gene_expression (expression) of mitogenic P2Y2 in blood vessels associated with stress
7) Confidence 0.28 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245998 Disease Relevance 0.48 Pain Relevance 0.03
Another report describes P2ry2 expression [74], but for this we only found low non-significant levels.
Positive_regulation (describes) of Gene_expression (expression) of P2ry2
8) Confidence 0.16 Published 2011 Journal BMC Genomics Section Body Doc Link PMC3024950 Disease Relevance 0.07 Pain Relevance 0.13
In a complex neural tissue, such as the human peripheral nerve trunk, ATP may activate P2X, P2Y, and adenosine receptors present on various cell types.
Spec (may) Positive_regulation (activate) of Gene_expression (present) of P2Y in peripheral nerve trunk associated with adenocard
9) Confidence 0.14 Published 2002 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 12382074 Disease Relevance 0.19 Pain Relevance 0.45
Evidence from a variety of experimental strategies, including genetic disruption studies and the development of selective antagonists, has indicated that the activation of P2X receptor subtypes, including P2X(3), P2X(2/3), P2X(4) and P2X(7), and P2Y (e.g., P2Y(2)) receptors, can modulate pain.
Positive_regulation (activation) of Gene_expression (subtypes) of P2Y associated with pain and antagonist
10) Confidence 0.07 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18042830 Disease Relevance 0.81 Pain Relevance 0.73

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox