INT105816

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Context Info
Confidence 0.78
First Reported 2002
Last Reported 2011
Negated 0
Speculated 2
Reported most in Body
Documents 53
Total Number 55
Disease Relevance 16.47
Pain Relevance 9.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (P2RY2) aging (P2RY2) plasma membrane (P2RY2)
embryo development (P2RY2) lysosome (P2RY2) signal transducer activity (P2RY2)
Anatomy Link Frequency
brain 6
bladder 4
nerves 2
lymphocytes 2
corneas 2
P2RY2 (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 183 100.00 Very High Very High Very High
Chronic pancreatitis 9 99.80 Very High Very High Very High
bradykinin 1 99.24 Very High Very High Very High
antagonist 230 98.96 Very High Very High Very High
Neuropeptide 5 98.78 Very High Very High Very High
Inflammation 140 98.68 Very High Very High Very High
Pain 42 98.40 Very High Very High Very High
agonist 175 98.08 Very High Very High Very High
Pyramidal cell 72 97.08 Very High Very High Very High
Spinal cord 1 97.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pancreatic Cancer 12 100.00 Very High Very High Very High
Injury 933 99.96 Very High Very High Very High
Pancreatitis 18 99.80 Very High Very High Very High
Anaplastic Astrocytoma 6 99.72 Very High Very High Very High
Cancer 16 98.88 Very High Very High Very High
INFLAMMATION 136 98.68 Very High Very High Very High
Stress 30 98.66 Very High Very High Very High
Pain 29 98.40 Very High Very High Very High
Interstitial Cystitis 35 97.00 Very High Very High Very High
Neuropathic Pain 6 96.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of P2Y2-R expression by siRNA
Gene_expression (expression) of P2Y2-R
1) Confidence 0.78 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2695252 Disease Relevance 0.19 Pain Relevance 0.05
When the experiment was performed on living animals, the profile of P2Y2-R expression in siRNA #2-treated animals presented a marked reduction 24 h after the wound was performed (189.36±10.73, p<0.001) compared to the control and Ap4A-treated corneas.
Gene_expression (expression) of P2Y2-R in corneas associated with injury
2) Confidence 0.78 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2695252 Disease Relevance 0.39 Pain Relevance 0
However, there are minimal data detailing expression of ectonucleotidases and type-2 purinergic receptors (P2R) in chronic pancreatitis and pancreatic cancer.
Gene_expression (expression) of P2R associated with pancreatic cancer and chronic pancreatitis
3) Confidence 0.77 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16920697 Disease Relevance 1.21 Pain Relevance 0.42
A1R and P2Y2R immunoreactivities were present in all three rat brain regions examined (Figure 3A, B, F).
Gene_expression (present) of P2Y2R in brain
4) Confidence 0.70 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC3009664 Disease Relevance 0 Pain Relevance 0.22
Immunogold electron microscopic observations of HA-A1R and Myc-P2Y2R expressed in HEK293T cells
Gene_expression (expressed) of P2Y2R
5) Confidence 0.70 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC3009664 Disease Relevance 0 Pain Relevance 0.10
We examined the expression of A1R and P2Y2R in brain using immunohistochemical analyses (Figure 2).
Spec (examined) Gene_expression (expression) of P2Y2R in brain
6) Confidence 0.70 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC3009664 Disease Relevance 0 Pain Relevance 0.08
Concerning the results 12 h after the wound, P2Y2-R staining in the three different treatments were similar to those obtained for 24 h after wounding (data not shown).
Gene_expression (staining) of P2Y2-R associated with injury
7) Confidence 0.67 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2695252 Disease Relevance 0.62 Pain Relevance 0
Cells were transfected with 300 nM P2Y2-R siRNA #1, 300 nM P2Y2-R siRNA #2, or the transfection reagent alone (control) for 72 h and then processed for ICC.
Gene_expression (transfected) of P2Y2-R
8) Confidence 0.67 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2695252 Disease Relevance 0.18 Pain Relevance 0.04
The analysis for a longer period of time (36 h after the wound) demonstrated a full recovery of the P2Y2 signaling, similar to the control (1424.14±14.1; Figure 2D).
Gene_expression (recovery) of P2Y2 in 14.1 associated with injury
9) Confidence 0.67 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2695252 Disease Relevance 0.51 Pain Relevance 0
To know the role of rabbit P2Y2-R in Ap4A-re-epithelialization process, a migration assay was performed on cells transfected with P2Y2-R siRNA #1 and P2Y2-R siRNA #2.
Gene_expression (transfected) of P2Y2-R
10) Confidence 0.67 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2695252 Disease Relevance 0.60 Pain Relevance 0
Staining for P2Y2 receptor was reduced in cells incubated with both P2Y2-R siRNA #1 (data not shown) and P2Y2-R siRNA #2 transfected cells.
Gene_expression (incubated) of P2Y2-R
11) Confidence 0.67 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2695252 Disease Relevance 0.16 Pain Relevance 0.04
(see Figure 1A) and P2Y2-R siRNA #2, 5?
Gene_expression (see) of P2Y2-R
12) Confidence 0.67 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2695252 Disease Relevance 0 Pain Relevance 0
The P2Y2-R reduction obtained with P2Y2-R siRNA #2 (Figure 2A) was greater than the observed reduction for P2Y2-R siRNA #1 (result not shown).
Spec (observed) Gene_expression (reduction) of P2Y2-R
13) Confidence 0.67 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2695252 Disease Relevance 0.14 Pain Relevance 0.04
Cells were transfected with 300 nM P2Y2-R siRNA #1, 300 nM P2Y2-R siRNA #2, or the transfection reagent alone (control) for 72 h and then processed for ICC.
Gene_expression (transfected) of P2Y2-R
14) Confidence 0.67 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2695252 Disease Relevance 0.18 Pain Relevance 0.04
These data indicate that the P2Y2-R levels were significantly reduced to approximately 32% of control levels by P2Y2-R siRNA #2.
Gene_expression (levels) of P2Y2-R
15) Confidence 0.67 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2695252 Disease Relevance 0.06 Pain Relevance 0
To know the role of rabbit P2Y2-R in Ap4A-re-epithelialization process, a migration assay was performed on cells transfected with P2Y2-R siRNA #1 and P2Y2-R siRNA #2.
Gene_expression (transfected) of P2Y2-R
16) Confidence 0.67 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2695252 Disease Relevance 0.60 Pain Relevance 0
The P2Y2-R reduction obtained with P2Y2-R siRNA #2 (Figure 2A) was greater than the observed reduction for P2Y2-R siRNA #1 (result not shown).
Gene_expression (reduction) of P2Y2-R
17) Confidence 0.67 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2695252 Disease Relevance 0.15 Pain Relevance 0.04
To design P2Y2-R specific siRNA duplexes, the rabbit P2Y2-R coding sequence (GenBank EU886321) was submitted to the Ambion siRNA target Finder website for siRNA prediction.
Gene_expression (design) of P2Y2-R
18) Confidence 0.67 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2695252 Disease Relevance 0 Pain Relevance 0
Thirty-six h after the wounds were performed, P2Y2-R staining was similar to the 24 h results (1400.05±19.49 for control and 1347.70±19.95 for Ap4A; Figure 2C, lower panel).
Gene_expression (staining) of P2Y2-R associated with injury
19) Confidence 0.67 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2695252 Disease Relevance 0.30 Pain Relevance 0
P2Y2 was markedly upregulated in biopsies of pancreatic cancer tissues and expressed by fibroblasts adjacent to tumors.
Gene_expression (expressed) of P2Y2 in fibroblasts associated with cancer and pancreatic cancer
20) Confidence 0.67 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16920697 Disease Relevance 1.56 Pain Relevance 0.43

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