INT105840

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Context Info
Confidence 0.44
First Reported 2002
Last Reported 2007
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.16
Pain Relevance 3.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adrbk1) aging (Adrbk1) cytoplasm (Adrbk1)
Anatomy Link Frequency
brain 4
neurons 2
Adrbk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 16 100.00 Very High Very High Very High
withdrawal 6 100.00 Very High Very High Very High
MU agonist 2 99.40 Very High Very High Very High
tolerance 2 97.68 Very High Very High Very High
Opioid 8 97.28 Very High Very High Very High
cerebral cortex 4 90.08 High High
Hippocampus 6 88.72 High High
Kinase C 78 85.20 High High
agonist 21 82.04 Quite High
Central grey 2 80.64 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 2 80.64 Quite High
Nash(non-alcoholic Steatohepatitis) 12 5.00 Very Low Very Low Very Low
Cognitive Disorder 1 5.00 Very Low Very Low Very Low
Aging 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
mol/L) pre-treatment was also able to enhance the effect of D110A,K220RGRK2 expression, resulting in an almost complete blockade of M1 mACh receptor desensitization in picrotoxin-treated neurons (see Fig. 4e).
Regulation (effect) of Gene_expression (expression) of GRK2 in neurons
1) Confidence 0.44 Published 2007 Journal Journal of Neurochemistry Section Body Doc Link PMC2658029 Disease Relevance 0 Pain Relevance 0.41
Acute and chronic morphine treatments and morphine withdrawal differentially regulate GRK2 and GRK5 gene expression in rat brain.
Regulation (regulate) of Gene_expression (expression) of GRK2 in brain associated with withdrawal and morphine
2) Confidence 0.43 Published 2002 Journal Neuropharmacology Section Title Doc Link 12384166 Disease Relevance 0.08 Pain Relevance 1.47
The current study investigated the potential regulatory effects of acute and chronic morphine administration and withdrawal on GRK2 and GRK5 gene expression in rat brain.
Spec (investigated) Regulation (effects) of Gene_expression (expression) of GRK2 in brain associated with withdrawal and morphine
3) Confidence 0.43 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12384166 Disease Relevance 0.08 Pain Relevance 1.21

General Comments

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