INT105848

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Context Info
Confidence 0.12
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.41
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cpox) extracellular space (Il1b) oxidoreductase activity (Cpox)
aging (Il1b) extracellular region (Il1b) cytoplasm (Cpox)
Anatomy Link Frequency
DRG 2
Il1b (Rattus norvegicus)
Cpox (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 7 99.46 Very High Very High Very High
substance P 8 96.48 Very High Very High Very High
COX-2 inhibitor 1 87.64 High High
Inflammation 1 82.16 Quite High
Hyperalgesia 1 81.12 Quite High
COX2 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 7 99.46 Very High Very High Very High
Hyperalgesia 1 5.00 Very Low Very Low Very Low
Nociception 1 5.00 Very Low Very Low Very Low
INFLAMMATION 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that in cultured DRG cells, NO potentiates the IL-1 beta-induced increase in COX-2 expression via a soluble guanylate cyclase-cGMP-independent pathway, resulting in facilitation of SP release.
IL-1 beta Positive_regulation (increase) of Gene_expression (expression) of COX in DRG associated with dorsal root ganglion and substance p
1) Confidence 0.12 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12384172 Disease Relevance 0.41 Pain Relevance 0.59

General Comments

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