INT105849

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Context Info
Confidence 0.07
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Title
Documents 1
Total Number 1
Disease Relevance 0.38
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Il1b, Ptgs1) nuclear envelope (Ptgs1) Golgi apparatus (Ptgs1)
endoplasmic reticulum (Ptgs1) cytoplasm (Ptgs1) lipid binding (Ptgs1)
Anatomy Link Frequency
afferent neurons 2
Il1b (Rattus norvegicus)
Ptgs1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
COX2 1 99.18 Very High Very High Very High
substance P 8 98.04 Very High Very High Very High
dorsal root ganglion 7 92.44 High High
COX-2 inhibitor 1 48.72 Quite Low
Inflammation 1 25.00 Low Low
Hyperalgesia 1 24.48 Low Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 7 91.96 High High
Hyperalgesia 1 5.00 Very Low Very Low Very Low
Nociception 1 5.00 Very Low Very Low Very Low
INFLAMMATION 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nitric oxide synergistically potentiates interleukin-1 beta-induced increase of cyclooxygenase-2 mRNA levels, resulting in the facilitation of substance P release from primary afferent neurons: involvement of cGMP-independent mechanisms.
interleukin-1 beta Positive_regulation (induced) of Positive_regulation (increase) of cyclooxygenase in afferent neurons associated with cox2 and substance p
1) Confidence 0.07 Published 2002 Journal Neuropharmacology Section Title Doc Link 12384172 Disease Relevance 0.38 Pain Relevance 0.51

General Comments

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