INT10585

Context Info Confidence 0.80 First Reported 1983 Last Reported 2010 Negated 0 Speculated 1 Reported most in Abstract Documents 53 Total Number 55 Disease Relevance 23.32 Pain Relevance 12.75

hydrolase activity, acting on glycosyl bonds (NAGLU) lysosome (NAGLU)

Anatomy Link Frequency urine 4 spinal 2 Clara cell 2 PGE1 1 tubule 1 NAGLU (Homo sapiens)

Pain Link Frequency Relevance Heat anesthesia 86 99.84 Osteoarthritis 4 99.40 aspirin 27 99.34 Restless leg syndrome 60 99.08 cINOD 41 98.92 Paracetamol 26 98.76 rheumatoid arthritis 16 98.44 Angina 4 98.44 isoflurane 20 97.60 halothane 2 96.20

Disease Link Frequency Relevance Heat Cyst 6 100.00 Injury 21 99.80 Osteoarthritis 4 99.40 Poisoning 2 99.16 Increased Venous Pressure Under Development 62 99.08 Toxicity 4 98.82 Disorders Of Creatine Metabolism 21 98.56 Rheumatoid Arthritis 16 98.44 Cv General 3 Under Development 4 98.44 Weight Loss 3 98.08

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Mutation

Event

Anatomy

Negation

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Disease term

We evaluated urinary excretion of N-acetyl-glucosaminidase (NAG) before and after lithotripsy in 50 patients treated with a low pressure spark gap lithotripter (Dornier HM3) and in 36 patients treated with a piezoelectric lithotripter (Wolf Piezolith 2200) in an attempt to evaluate their side effects on renal tissue.

Localization (excretion) of NAG

1) Confidence 0.80 Published 1990 Journal Urol. Res. Section Abstract Doc Link 1699345 Disease Relevance 0.09 Pain Relevance 0.14

We evaluated urinary excretion of N-acetyl-glucosaminidase (NAG) before and after lithotripsy in 50 patients treated with a low pressure spark gap lithotripter (Dornier HM3) and in 36 patients treated with a piezoelectric lithotripter (Wolf Piezolith 2200) in an attempt to evaluate their side effects on renal tissue.

Localization (excretion) of N-acetyl-glucosaminidase

2) Confidence 0.80 Published 1990 Journal Urol. Res. Section Abstract Doc Link 1699345 Disease Relevance 0.09 Pain Relevance 0.14

Urinary N-acetyl-beta-D-glucosaminidase (NAG) excretion, which was described as the creatinine ratio, was significantly higher in the children with hypercalciuria.

Localization (excretion) of Urinary N-acetyl-beta-D-glucosaminidase associated with kidney stones

3) Confidence 0.74 Published 1997 Journal Turk. J. Pediatr. Section Abstract Doc Link 9339112 Disease Relevance 0.93 Pain Relevance 0.05

Urinary N-acetyl-beta-D-glucosaminidase (NAG) excretion, which was described as the creatinine ratio, was significantly higher in the children with hypercalciuria.

Localization (excretion) of NAG associated with kidney stones

4) Confidence 0.74 Published 1997 Journal Turk. J. Pediatr. Section Abstract Doc Link 9339112 Disease Relevance 0.92 Pain Relevance 0.05

Creatinine clearance was slightly more affected by iodixanol, whereas the increase in renal excretion of N-acetyl-beta-glucosaminidase (NAG) in the first 24-h collection period after the examination was significantly higher (p < 0.01) with iopamidol.

Localization (excretion) of N-acetyl-beta-glucosaminidase associated with disorders of creatine metabolism

5) Confidence 0.71 Published 1996 Journal Eur Radiol Section Abstract Doc Link 8797943 Disease Relevance 0.10 Pain Relevance 0

Creatinine clearance was slightly more affected by iodixanol, whereas the increase in renal excretion of N-acetyl-beta-glucosaminidase (NAG) in the first 24-h collection period after the examination was significantly higher (p < 0.01) with iopamidol.

Localization (excretion) of NAG associated with disorders of creatine metabolism

6) Confidence 0.71 Published 1996 Journal Eur Radiol Section Abstract Doc Link 8797943 Disease Relevance 0.10 Pain Relevance 0

In addition, the increased urinary excretion of beta2-microglobulin (beta2MG) and N-acetyl-beta-D-glucosaminidase (NAG) on admission was also improved during the treatment.

Localization (excretion) of NAG

7) Confidence 0.69 Published 2008 Journal Clin. Exp. Nephrol. Section Abstract Doc Link 18274699 Disease Relevance 0.81 Pain Relevance 0.37

In addition, the increased urinary excretion of beta2-microglobulin (beta2MG) and N-acetyl-beta-D-glucosaminidase (NAG) on admission was also improved during the treatment.

Localization (excretion) of N-acetyl-beta-D-glucosaminidase

8) Confidence 0.69 Published 2008 Journal Clin. Exp. Nephrol. Section Abstract Doc Link 18274699 Disease Relevance 0.81 Pain Relevance 0.37

Twenty-four-hour urinary excretion of N-acetyl-beta-glucosaminidase (NAG), beta2-microglobulin, protein, glucose, blood urea nitrogen (BUN), and serum creatinine concentrations were measured before and after anesthesia.

Localization (excretion) of N-acetyl-beta-glucosaminidase in blood

9) Confidence 0.68 Published 1998 Journal Anesthesiology Section Body Doc Link 9710388 Disease Relevance 0.09 Pain Relevance 0

Increased urinary N-acetyl-beta-glucosaminidase excretions were seen in the low-flow and high-flow sevoflurane groups, but not in the low-flow isoflurane group (P < 0.01).

Localization (excretions) of N-acetyl-beta-glucosaminidase

10) Confidence 0.68 Published 1998 Journal Anesthesiology Section Body Doc Link 9710388 Disease Relevance 0.07 Pain Relevance 0

Inulin clearance and urinary beta(2)-microglobulin and N-acetyl-beta-D-glucosaminidase (NAG) excretion (to determine glomerular filtration rate and tubular damage, respectively) were measured at different perioperative periods (anesthesia induction, hepatectomy, anhepatic phase, biliary anastomosis, and 24 hours after surgery).

Localization (excretion) of N-acetyl-beta-D-glucosaminidase associated with anesthesia

11) Confidence 0.65 Published 1996 Journal Hepatology Section Abstract Doc Link 8675159 Disease Relevance 0.09 Pain Relevance 0.09

Inulin clearance and urinary beta(2)-microglobulin and N-acetyl-beta-D-glucosaminidase (NAG) excretion (to determine glomerular filtration rate and tubular damage, respectively) were measured at different perioperative periods (anesthesia induction, hepatectomy, anhepatic phase, biliary anastomosis, and 24 hours after surgery).

Localization (excretion) of NAG associated with anesthesia

12) Confidence 0.65 Published 1996 Journal Hepatology Section Abstract Doc Link 8675159 Disease Relevance 0.09 Pain Relevance 0.09

In addition, they measured urinary excretion of N-acetyl-beta-glucosaminidase (NAG), a sensitive index of renal tubular damage, during the 3-day period after anesthesia.

Localization (excretion) of NAG associated with anesthesia

13) Confidence 0.64 Published 1995 Journal Anesthesiology Section Abstract Doc Link 7661345 Disease Relevance 0.08 Pain Relevance 0.51

In addition, they measured urinary excretion of N-acetyl-beta-glucosaminidase (NAG), a sensitive index of renal tubular damage, during the 3-day period after anesthesia.

Localization (excretion) of N-acetyl-beta-glucosaminidase associated with anesthesia

14) Confidence 0.64 Published 1995 Journal Anesthesiology Section Abstract Doc Link 7661345 Disease Relevance 0.08 Pain Relevance 0.51

Cyclosporine induced a slight increase in AAP and NAG excretion.

Localization (excretion) of NAG

15) Confidence 0.62 Published 1989 Journal Ann. Biol. Clin. (Paris) Section Abstract Doc Link 2571317 Disease Relevance 0.15 Pain Relevance 0.24

The urinary excretion of N-acetyl-beta-D-glucosaminidase (NAG) was elevated in four patients; two had other biochemical evidence of renal damage while the other two patients appeared normal, although they had both received spinal irradiation in the past.

Localization (excretion) of N-acetyl-beta-D-glucosaminidase in spinal

16) Confidence 0.62 Published 1987 Journal Br. J. Rheumatol. Section Abstract Doc Link 3664158 Disease Relevance 0.95 Pain Relevance 0.54

The urinary excretion of N-acetyl-beta-D-glucosaminidase (NAG) was elevated in four patients; two had other biochemical evidence of renal damage while the other two patients appeared normal, although they had both received spinal irradiation in the past.

Localization (excretion) of NAG in spinal

17) Confidence 0.62 Published 1987 Journal Br. J. Rheumatol. Section Abstract Doc Link 3664158 Disease Relevance 0.95 Pain Relevance 0.54

Urinary NAG excretion after anesthesia-free extracorporeal lithotripsy of renal stones: a marker of early tubular damage.

Localization (excretion) of NAG associated with anesthesia

18) Confidence 0.61 Published 1990 Journal Urol. Res. Section Title Doc Link 1699345 Disease Relevance 0.09 Pain Relevance 0.26

The urinary excretion of NAG increased after both spark gap lithotripsy using the modified HM3 and piezoelectric lithotripsy.

Localization (excretion) of NAG

19) Confidence 0.61 Published 1990 Journal Urol. Res. Section Abstract Doc Link 1699345 Disease Relevance 0.08 Pain Relevance 0.16

Neither auranofin nor myocrisin were found to further significantly increase beta 2M and NAG excretion.

Localization (excretion) of NAG

20) Confidence 0.55 Published 1983 Journal Clin. Rheumatol. Section Abstract Doc Link 6432404 Disease Relevance 0.69 Pain Relevance 0.52

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