INT10586

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Context Info
Confidence 0.68
First Reported 1981
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 15
Total Number 15
Disease Relevance 8.67
Pain Relevance 3.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (B2M) plasma membrane (B2M)
Anatomy Link Frequency
urine 2
blood 1
proximal 1
urothelial cells 1
BEN 1
B2M (Homo sapiens)
Pain Link Frequency Relevance Heat
Analgesic 33 99.84 Very High Very High Very High
Paracetamol 15 97.96 Very High Very High Very High
corticosteroid 3 94.08 High High
aspirin 8 90.24 High High
diclofenac 3 83.68 Quite High
anesthesia 5 82.16 Quite High
cINOD 3 81.96 Quite High
Inflammation 1 77.48 Quite High
antagonist 1 73.36 Quite High
isoflurane 2 50.00 Quite Low
Disease Link Frequency Relevance Heat
Cyst 2 100.00 Very High Very High Very High
Disorders Of Creatine Metabolism 5 99.96 Very High Very High Very High
Pre-eclampsia 12 99.78 Very High Very High Very High
Malignant Neoplastic Disease 12 99.56 Very High Very High Very High
Renal Disease 52 99.44 Very High Very High Very High
Balkan Nephropathy 6 99.28 Very High Very High Very High
Cancer 3 99.04 Very High Very High Very High
Congenital Anomalies 4 96.84 Very High Very High Very High
Pyelonephritis 4 95.96 Very High Very High Very High
Weight Loss 1 95.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is suggested that the increased beta 2-microglobulin excretion in analgesic nephropathy is due to secretion from abnormal urothelial cells as well as reduced tubular catabolism.
Localization (excretion) of 2-microglobulin in urothelial cells associated with analgesic and renal disease
1) Confidence 0.68 Published 1982 Journal Clin. Nephrol. Section Abstract Doc Link 6183039 Disease Relevance 1.08 Pain Relevance 0.64
Enhanced secretion of beta 2-microglobulin occurs from epithelial cancer cells.
Localization (secretion) of 2-microglobulin associated with cancer
2) Confidence 0.68 Published 1982 Journal Clin. Nephrol. Section Abstract Doc Link 6183039 Disease Relevance 1.05 Pain Relevance 0.48
Mean fractional excretion of beta 2-microglobulin was higher (8.61 +/- 1.76 SEM) in patients with analgesic nephropathy than in those with glomerulonephritis (1.13 +/- 0.76) (P less than 0.025).
Localization (excretion) of 2-microglobulin associated with analgesic and renal disease
3) Confidence 0.60 Published 1982 Journal Clin. Nephrol. Section Abstract Doc Link 6183039 Disease Relevance 1.23 Pain Relevance 0.59
Observations of beta 2-microglobulin excretion into the urine].
Localization (excretion) of beta 2-microglobulin in urine
4) Confidence 0.40 Published 1985 Journal Hinyokika Kiyo Section Title Doc Link 3911767 Disease Relevance 0.50 Pain Relevance 0.05
Creatinine clearance, beta 2-microglobulin clearance and urinary excretion of N-acetyl-glucosaminidase did not reveal evidence for acute renal impairment.
Localization (excretion) of beta 2-microglobulin associated with disorders of creatine metabolism
5) Confidence 0.38 Published 1987 Journal Arzneimittelforschung Section Abstract Doc Link 3501723 Disease Relevance 0.30 Pain Relevance 0.05
Direct tubular damage from imidazole 2-hydroxybenzoate was also excluded by normal excretion of beta-2-microglobulin and N-acetyl-beta-D-glucosaminidase.
Localization (excretion) of beta-2-microglobulin
6) Confidence 0.17 Published 1992 Journal Int J Clin Pharmacol Ther Toxicol Section Abstract Doc Link 1506125 Disease Relevance 0.24 Pain Relevance 0.08
In patients with kidney transplantation the urinary excretion of beta 2-microglobulin, AAP, gamma-GT and AP are several times higher than in normals.
Localization (excretion) of 2-microglobulin in kidney
7) Confidence 0.10 Published 1981 Journal Contrib Nephrol Section Abstract Doc Link 6164517 Disease Relevance 0.37 Pain Relevance 0.12
In patients with preeclampsia the renal excretion of beta 2-microglobulin allows to differentiate between a primary preeclampsia and a preeclampsia superimposed upon chronic pyelonephritis.
Localization (excretion) of 2-microglobulin associated with pyelonephritis and pre-eclampsia
8) Confidence 0.10 Published 1981 Journal Contrib Nephrol Section Abstract Doc Link 6164517 Disease Relevance 0.39 Pain Relevance 0.09
Twenty-four-hour urinary excretion of N-acetyl-beta-glucosaminidase (NAG), beta2-microglobulin, protein, glucose, blood urea nitrogen (BUN), and serum creatinine concentrations were measured before and after anesthesia.
Localization (excretion) of beta2-microglobulin in blood
9) Confidence 0.10 Published 1998 Journal Anesthesiology Section Body Doc Link 9710388 Disease Relevance 0.09 Pain Relevance 0
Aminoglycosides (tobramycin, UK 18,892) lead to a cumulative increase of the renal excretion of beta 2-microglobulin and AAP while cephalosporins induce an increase of total proteins in the final urine under the same conditions.
Localization (excretion) of 2-microglobulin in urine
10) Confidence 0.10 Published 1981 Journal Contrib Nephrol Section Abstract Doc Link 6164517 Disease Relevance 0.28 Pain Relevance 0.13
Urinary excretion of the low molecular weight protein beta 2-microglobulin and tubular enzymes--alanine aminopeptidase (AAP), gamma-glutamyl transpeptidase (gamma-GT) and alkaline phosphatase (AP)--are very sensitive parameters for proximal tubular lesions.
Localization (excretion) of 2-microglobulin in proximal
11) Confidence 0.10 Published 1981 Journal Contrib Nephrol Section Abstract Doc Link 6164517 Disease Relevance 0.31 Pain Relevance 0
In addition, the increased urinary excretion of beta2-microglobulin (beta2MG) and N-acetyl-beta-D-glucosaminidase (NAG) on admission was also improved during the treatment.
Localization (excretion) of beta2-microglobulin
12) Confidence 0.05 Published 2008 Journal Clin. Exp. Nephrol. Section Abstract Doc Link 18274699 Disease Relevance 0.81 Pain Relevance 0.36
To assess renal function the urinary excretions of beta 2-microglobulin, albumin and Tamm-Horsfall protein were determined by radioimmunoassay.
Localization (excretions) of beta 2-microglobulin
13) Confidence 0.04 Published 1995 Journal J. Urol. Section Abstract Doc Link 7861490 Disease Relevance 0.23 Pain Relevance 0.12
Urinary excretion of albumin before acetaminophen treatment was significantly higher in patients with GN and BEN than in healthy adults, however, beta 2-microglobulin excretion was increased in BEN patients only.
Localization (excretion) of 2-microglobulin in BEN associated with paracetamol, balkan nephropathy and renal disease
14) Confidence 0.03 Published 1999 Journal Ren Fail Section Abstract Doc Link 10516997 Disease Relevance 1.02 Pain Relevance 0.74
Urinary excretion of five low molecular weight proteins (LMWP) [beta 2-microglobulin (beta 2m), cystatin C (cyst C), Clara cell protein (CC16), retinol-binding protein (RBP) and alpha 1-microglobulin (alpha 1m)], albumin and N-acetyl-beta-D-glucosaminidase (NAG) were quantified in 16 patients who followed a weight reduction program which included Chinese herbs, which have been incriminated in the genesis of Chinese herbs nephropathy (CHN).
Localization (excretion) of 1-microglobulin in Clara cell associated with weight loss, renal disease and cyst
15) Confidence 0.00 Published 1995 Journal Kidney Int. Section Abstract Doc Link 8544416 Disease Relevance 0.77 Pain Relevance 0

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