INT105860

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Context Info
Confidence 0.64
First Reported 2002
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.37
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (EGF) extracellular space (EGF) extracellular region (EGF)
plasma membrane (EGF)
Anatomy Link Frequency
finger 2
EGF (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 18 99.80 Very High Very High Very High
Neuropeptide 2 95.36 Very High Very High Very High
Pain 2 93.52 High High
Inflammation 10 92.32 High High
COX2 4 70.92 Quite High
cINOD 12 5.00 Very Low Very Low Very Low
COX-2 inhibitor 4 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
methotrexate 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glioma 8 99.86 Very High Very High Very High
Lung Cancer 141 95.76 Very High Very High Very High
Malignant Neoplastic Disease 17 95.24 Very High Very High Very High
Pain 2 93.52 High High
INFLAMMATION 12 92.32 High High
Disease 29 91.80 High High
Cancer 53 91.04 High High
Stress 2 90.28 High High
Disease Progression 3 87.60 High High
Adhesions 1 83.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that transactivation of the EGF receptor as well as stimulation of the mitogen activated/extracellular signal-regulated protein kinase (ERK) are essential for substance P/NK-1 receptor-induced activation of Egr-1 biosynthesis.
Positive_regulation (essential) of Positive_regulation (transactivation) of EGF associated with substance p
1) Confidence 0.64 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12384223 Disease Relevance 0.47 Pain Relevance 0.51
Substance P induced biosynthesis of the zinc finger transcription factor Egr-1 in human glioma cells requires activation of the epidermal growth factor receptor and of extracellular signal-regulated protein kinase.
Positive_regulation (requires) of Positive_regulation (activation) of epidermal growth factor in finger associated with glioma and substance p
2) Confidence 0.46 Published 2002 Journal Neurosci. Lett. Section Title Doc Link 12384223 Disease Relevance 0.55 Pain Relevance 0.47
Functional analyses of these mutant EGFRs in the cultured cells demonstrated that all EGFR mutants have enhanced tyrosine kinase activity in response to epidermal growth factor and increased sensitivity to EGFR inhibitor Erlotinib.
Positive_regulation (enhanced) of Positive_regulation (response) of epidermal growth factor
3) Confidence 0.42 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2970593 Disease Relevance 0.42 Pain Relevance 0
In fact, recently published in vitro experiments show that Src family kinases are highly activated in cetuximab-resistant cells and that they enhance EGF-R activation despite the cetuximab-bound receptor.
Positive_regulation (enhance) of Positive_regulation (activation) of EGF-R
4) Confidence 0.32 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2868849 Disease Relevance 0.61 Pain Relevance 0
Interestingly, in Ist-Mes-2 cells, EGF stimulation induced EGFR phosphorylation as expected, but did not induce AKT and ERK phosphorylation, suggesting other possible signalling pathways of EGFR.


Neg (not) Positive_regulation (induce) of Positive_regulation (stimulation) of EGF
5) Confidence 0.12 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2828989 Disease Relevance 0.16 Pain Relevance 0.04
Interestingly, in Ist-Mes-2 cells, EGF stimulation induced EGFR phosphorylation as expected, but did not induce AKT and ERK phosphorylation, suggesting other possible signalling pathways of EGFR.


Neg (not) Positive_regulation (induced) of Positive_regulation (stimulation) of EGF
6) Confidence 0.12 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2828989 Disease Relevance 0.16 Pain Relevance 0.04

General Comments

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