INT105865

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Context Info
Confidence 0.12
First Reported 2002
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 1.82
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PRKG1) signal transduction (PRKG1) plasma membrane (PRKG1)
cytoplasm (PRKG1)
Anatomy Link Frequency
spinal cord 4
neurons 2
brain 2
PRKG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
long-term potentiation 17 99.84 Very High Very High Very High
Spinal cord 6 99.56 Very High Very High Very High
intrathecal 1 98.08 Very High Very High Very High
medulla 11 97.28 Very High Very High Very High
Inflammation 4 97.00 Very High Very High Very High
midbrain 1 92.76 High High
amygdala 1 91.92 High High
Rostral ventrolateral medulla 55 90.92 High High
Central nervous system 13 88.32 High High
Hyperalgesia 10 77.28 Quite High
Disease Link Frequency Relevance Heat
Death 66 100.00 Very High Very High Very High
Nociception 13 100.00 Very High Very High Very High
Natriuresis 2 98.48 Very High Very High Very High
INFLAMMATION 5 97.00 Very High Very High Very High
Targeted Disruption 3 96.88 Very High Very High Very High
Increased Venous Pressure Under Development 4 96.32 Very High Very High Very High
Urological Neuroanatomy 1 91.52 High High
Hyperalgesia 11 77.28 Quite High
Disease 21 76.84 Quite High
Poisoning 7 65.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To further evaluate this pathway we assessed the effects of the PKG-inhibiting cGMP analog Rp-8-Br-cGMPS in the rat formalin assay and analyzed the regulation of PKG expression in rat lumbar spinal cord.
Spec (analyzed) Regulation (regulation) of Gene_expression (expression) of PKG in spinal cord associated with spinal cord
1) Confidence 0.12 Published 2003 Journal Nitric Oxide Section Abstract Doc Link 12620371 Disease Relevance 0.26 Pain Relevance 0.22
Proper PRKG1 expression is important for proper brain development [44].
Regulation (important) of Gene_expression (expression) of PRKG1 in brain
2) Confidence 0.12 Published 2007 Journal BMC Genet Section Body Doc Link PMC1853105 Disease Relevance 0.15 Pain Relevance 0.12
The rat formalin assay was used to assess effects of the cyclic guanosine mono-phosphate (cGMP) analog, 8-bromo-cGMP on nociception and cGMP dependent protein kinase I (protein kinase G; PKG-I) expression in lumbar spinal cord.
Regulation (effects) of Gene_expression (expression) of PKG in spinal cord associated with nociception and spinal cord
3) Confidence 0.09 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12384231 Disease Relevance 0.34 Pain Relevance 0.22
Given that the NO/cGMP/PKG pathway is involved in LTP, a phenomenon that is altered in the early phases of the pathology in transgenic mouse models (Trinchese et al 2004), it has been demonstrated that this pathway has a protective role with regards to A?
Regulation (involved) of Gene_expression (pathway) of PKG associated with targeted disruption and long-term potentiation
4) Confidence 0.09 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2518390 Disease Relevance 0.42 Pain Relevance 0.18
PKG expression is not altered by axotomy [61], possibly explaining our findings of similar PKG-dependent 8-Br-cGMP actions in both control and axotomized neurons.
Neg (not) Spec (possibly) Regulation (altered) of Gene_expression (expression) of PKG in neurons
5) Confidence 0.05 Published 2009 Journal Mol Pain Section Body Doc Link PMC2673211 Disease Relevance 0.10 Pain Relevance 0.03
On the other hand, the protein levels of NOS I and PKG during the pro-death phase were not affected by these pretreatments.


Neg (not) Regulation (affected) of Gene_expression (levels) of PKG associated with death
6) Confidence 0.02 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2848001 Disease Relevance 0.55 Pain Relevance 0.38

General Comments

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