INT105873

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Context Info
Confidence 0.27
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.67
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ins1, Lep) extracellular region (Ins1, Lep) intracellular (Lep)
carbohydrate metabolic process (Ins1) lipid metabolic process (Lep) cytoplasm (Ins1)
Anatomy Link Frequency
plasma 2
Ins1 (Rattus norvegicus)
Lep (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 3 99.22 Very High Very High Very High
amygdala 2 76.60 Quite High
mu opioid receptor 1 75.00 Quite High
MU agonist 1 34.84 Quite Low
Disease Link Frequency Relevance Heat
Obesity 4 100.00 Very High Very High Very High
Hyperphagia 1 97.48 Very High Very High Very High
Urological Neuroanatomy 3 87.36 High High
Weight Gain 3 74.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, the mu opioid system in reward-related areas may be inhibited in dietary obesity, probably by increased plasma leptin and insulin, and this may represent a failed homeostatic attempt to limit overeating and eventually obesity.
insulin Negative_regulation (inhibited) of Positive_regulation (increased) of leptin in plasma associated with hyperphagia, obesity and opioid
1) Confidence 0.27 Published 2002 Journal Brain Res. Section Abstract Doc Link 12384255 Disease Relevance 0.67 Pain Relevance 0.31

General Comments

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