INT105873

Context Info Confidence 0.27 First Reported 2002 Last Reported 2002 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.67 Pain Relevance 0.31

extracellular space (Ins1, Lep) extracellular region (Ins1, Lep) intracellular (Lep) carbohydrate metabolic process (Ins1) lipid metabolic process (Lep) cytoplasm (Ins1)

Anatomy Link Frequency plasma 2 Ins1 (Rattus norvegicus) Lep (Rattus norvegicus)

Pain Link Frequency Relevance Heat Opioid 3 99.22 amygdala 2 76.60 mu opioid receptor 1 75.00 MU agonist 1 34.84

Disease Link Frequency Relevance Heat Obesity 4 100.00 Hyperphagia 1 97.48 Urological Neuroanatomy 3 87.36 Weight Gain 3 74.52

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Indeed, the mu opioid system in reward-related areas may be inhibited in dietary obesity, probably by increased plasma leptin and insulin, and this may represent a failed homeostatic attempt to limit overeating and eventually obesity.

insulin Negative_regulation (inhibited) of Positive_regulation (increased) of leptin in plasma associated with hyperphagia, obesity and opioid

1) Confidence 0.27 Published 2002 Journal Brain Res. Section Abstract Doc Link 12384255 Disease Relevance 0.67 Pain Relevance 0.31

General Comments

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