INT105881

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Context Info
Confidence 0.51
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.99
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bcl2l1) intracellular (Bcl2l1) response to stress (Bcl2l1)
cytoplasm (Bcl2l1) cytosol (Bcl2l1) cell proliferation (Bcl2l1)
Anatomy Link Frequency
brain 1
Bcl2l1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 14 99.24 Very High Very High Very High
Inflammation 19 96.76 Very High Very High Very High
vincristine 1 81.76 Quite High
cINOD 1 79.52 Quite High
adenocard 1 71.88 Quite High
cytokine 14 56.48 Quite High
Analgesic 1 45.56 Quite Low
ischemia 14 44.40 Quite Low
Central nervous system 5 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 8 99.54 Very High Very High Very High
Apoptosis 12 99.32 Very High Very High Very High
Poisoning 1 98.80 Very High Very High Very High
INFLAMMATION 23 96.76 Very High Very High Very High
Chronic Lymphoid Leukemia 9 93.96 High High
Injury 12 91.40 High High
Colon Cancer 1 89.08 High High
Stroke 35 75.00 Quite High
Stress 3 68.88 Quite High
Hepatotoxicity 3 59.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, administration of arjunolic acid 4 h after acetaminophen intoxication reduced acetaminophen-induced JNK and downstream Bcl-2 and Bcl-xL phosphorylation, thus protecting against mitochondrial permeabilization, loss of mitochondrial membrane potential, and cytochrome c release.
Phosphorylation (phosphorylation) of Bcl-xL associated with paracetamol and poisoning
1) Confidence 0.51 Published 2010 Journal Free Radic. Biol. Med. Section Abstract Doc Link 19969075 Disease Relevance 0.51 Pain Relevance 1.00
Such treatment also minimizes apoptotic cell death by influencing STAT-3 phosphorylation and Bcl-xL expression in the brain.
Phosphorylation (phosphorylation) of Bcl-xL in brain associated with apoptosis and death
2) Confidence 0.22 Published 2010 Journal Journal of Neuroinflammation Section Abstract Doc Link PMC3022819 Disease Relevance 0.68 Pain Relevance 0.19
G(2)-M arrest was associated with phosphorylation of Bcl2 (but not BAD, Bax, or Bcl-XL): both of these end points were abrogated by treatment with a calcium chelator.
Phosphorylation (phosphorylation) of Bcl-XL
3) Confidence 0.05 Published 2002 Journal Cancer Res. Section Abstract Doc Link 12384529 Disease Relevance 0.80 Pain Relevance 0.12

General Comments

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