INT105882

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Context Info
Confidence 0.59
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 8.15
Pain Relevance 3.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bcl2) aging (Bcl2) cell morphogenesis (Bcl2)
endoplasmic reticulum (Bcl2) intracellular (Bcl2) response to stress (Bcl2)
Anatomy Link Frequency
bands 1
endometrium 1
Bcl2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 3 99.64 Very High Very High Very High
Paracetamol 14 99.44 Very High Very High Very High
vincristine 4 99.36 Very High Very High Very High
Dismenorea 11 97.66 Very High Very High Very High
Ultiva 9 96.20 Very High Very High Very High
Clonidine 6 91.36 High High
cINOD 4 79.52 Quite High
ischemia 2 77.16 Quite High
anesthesia 1 75.52 Quite High
cerebral cortex 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 28 100.00 Very High Very High Very High
Myocardial Infarction 2 99.78 Very High Very High Very High
Chronic Lymphoid Leukemia 36 99.68 Very High Very High Very High
Hypoxia 20 99.44 Very High Very High Very High
Poisoning 1 99.00 Very High Very High Very High
Prostate Cancer 90 98.60 Very High Very High Very High
Dysmenorrhea 11 97.66 Very High Very High Very High
Cancer 25 97.20 Very High Very High Very High
Colon Cancer 4 89.08 High High
Toxicity 24 82.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Myocardial infarct size, the phosphorylation of ERK1/2, Bcl2, Bax and cytochrome c and the expression of genes influencing Ca2+ homeostasis were assessed.
Phosphorylation (phosphorylation) of Bcl2 associated with myocardial infarction
1) Confidence 0.59 Published 2010 Journal Physiol Res Section Abstract Doc Link 19681651 Disease Relevance 0.63 Pain Relevance 0.93
In addition, administration of arjunolic acid 4 h after acetaminophen intoxication reduced acetaminophen-induced JNK and downstream Bcl-2 and Bcl-xL phosphorylation, thus protecting against mitochondrial permeabilization, loss of mitochondrial membrane potential, and cytochrome c release.
Phosphorylation (phosphorylation) of Bcl-2 associated with paracetamol and poisoning
2) Confidence 0.45 Published 2010 Journal Free Radic. Biol. Med. Section Abstract Doc Link 19969075 Disease Relevance 0.56 Pain Relevance 1.00
G(2)-M arrest was associated with phosphorylation of Bcl2 (but not BAD, Bax, or Bcl-XL): both of these end points were abrogated by treatment with a calcium chelator.
Phosphorylation (phosphorylation) of Bcl2
3) Confidence 0.38 Published 2002 Journal Cancer Res. Section Abstract Doc Link 12384529 Disease Relevance 0.80 Pain Relevance 0.12
Neither sulindac sulfide (a cyclooxygenase inhibitor) nor sulindac sulfone induced G(2)-M arrest, Bcl2 phosphorylation, microtubule disassembly, or cell shape changes.
Phosphorylation (phosphorylation) of Bcl2
4) Confidence 0.38 Published 2002 Journal Cancer Res. Section Abstract Doc Link 12384529 Disease Relevance 0.83 Pain Relevance 0.04
Because microtubule-active drugs such as vincristine also induced G(2)-M arrest and Bcl2 phosphorylation in WSU-CLL, whereas the genotoxic drugs etoposide and doxorubicin did not, we examined the effect of CP461 on microtubules by indirect immunofluoresence microscopy.
Phosphorylation (phosphorylation) of Bcl2 associated with chronic lymphoid leukemia and vincristine
5) Confidence 0.38 Published 2002 Journal Cancer Res. Section Abstract Doc Link 12384529 Disease Relevance 0.87 Pain Relevance 0.12
Although CP461 induces p53 up-regulation, G(2)-M arrest and Bcl2 phosphorylation were independent of p53.
Phosphorylation (phosphorylation) of Bcl2
6) Confidence 0.38 Published 2002 Journal Cancer Res. Section Abstract Doc Link 12384529 Disease Relevance 0.78 Pain Relevance 0.12
The expression of ER and bcl-2 was weaker in the adenomyotic endometrium treated with danazol than in that treated with gonadotro-pin-releasing hormone agonist (GnRHa), whereas bcl-2 phosphorylated on serine-87 was more intensely expressed in danazol-treated adenomyotic endometrium than in the GnRHa-treated one.
Phosphorylation (phosphorylated) of bcl-2 in endometrium associated with agonist and dismenorea
7) Confidence 0.15 Published 2004 Journal Int. J. Gynecol. Pathol. Section Abstract Doc Link 15213601 Disease Relevance 1.11 Pain Relevance 0.87
Cytosol was isolated and separated by 12% SDS-PAGE and probed with tyrosine phosphorylated (p) -Bax, Bad, Bcl-2 and Bcl-xl antibodies and bands were detected.
Phosphorylation (phosphorylated) of Bcl-2 in bands
8) Confidence 0.03 Published 2010 Journal Neurochem. Res. Section Abstract Doc Link 19597709 Disease Relevance 0.84 Pain Relevance 0.22
The present study aims to investigate the mechanism of phosphorylation of apoptotic proteins and tests the hypothesis that the hypoxia-induced increased tyrosine phosphorylation of apoptotic proteins Bcl-2 and Bcl-xl is Ca(2+)-influx-dependent.
Phosphorylation (phosphorylation) of Bcl-2 associated with hypoxia and apoptosis
9) Confidence 0.03 Published 2010 Journal Neurochem. Res. Section Abstract Doc Link 19597709 Disease Relevance 0.87 Pain Relevance 0.21
The studies to evaluate the ability of docetaxel to stabilize tubulin, found that it had a significant anti-tumor effect in androgen-dependent and androgen-independent prostate cancer cell lines.11,12 In addition, docetaxel caused apoptosis by inducing phosphorylation of bcl-2, which found to be overexpressed in androgen-resistant prostate cancer.13 Thus, these in vitro results encouraged the clinical use of docetaxel in HRPC patients.
Phosphorylation (phosphorylation) of bcl-2 associated with cancer, prostate cancer and apoptosis
10) Confidence 0.01 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615369 Disease Relevance 0.86 Pain Relevance 0.04
Docetaxel induces polymerization of microtubules and phosphorylation of bcl-2 protein.
Phosphorylation (phosphorylation) of bcl-2 protein
11) Confidence 0.01 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1550253 Disease Relevance 0 Pain Relevance 0.06

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