INT105891

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Context Info
Confidence 0.12
First Reported 2002
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.66
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IGFBP1) extracellular space (IGFBP1) extracellular region (IGFBP1)
IGFBP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 77 100.00 Very High Very High Very High
cINOD 2 85.88 High High
cytokine 16 5.00 Very Low Very Low Very Low
Inflammation 9 5.00 Very Low Very Low Very Low
methotrexate 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 77 100.00 Very High Very High Very High
Obesity 14 87.52 High High
INFLAMMATION 12 85.64 High High
Disease 9 66.12 Quite High
Disorder Of Lipid Metabolism 4 17.20 Low Low
Appetite Loss 8 5.00 Very Low Very Low Very Low
Renal Disease 4 5.00 Very Low Very Low Very Low
Cancer 3 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Elevated IGFBP-1 levels as observed in patients with RA could further reduce free IGF-I availability and action [21].
Negative_regulation (reduce) of Positive_regulation (Elevated) of IGFBP-1 associated with rheumatoid arthritis
1) Confidence 0.12 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206381 Disease Relevance 0.58 Pain Relevance 0.16
The binding constants for OTA and WAR decreased in the series D2z.Gt;D3>D1.
Negative_regulation (decreased) of Positive_regulation (constants) of binding
2) Confidence 0.06 Published 2002 Journal Chem. Biol. Interact. Section Abstract Doc Link 12385724 Disease Relevance 0.09 Pain Relevance 0.09

General Comments

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