INT105897

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Context Info
Confidence 0.60
First Reported 2002
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 1.60
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (UGT1A1) endoplasmic reticulum (UGT1A1) enzyme binding (UGT1A1)
Anatomy Link Frequency
liver 2
intestine 1
UGT1A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 39 64.04 Quite High
Morphine 5 61.80 Quite High
Bile 27 38.92 Quite Low
Kinase C 12 5.00 Very Low Very Low Very Low
Potency 10 5.00 Very Low Very Low Very Low
tolerance 8 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
Paracetamol 6 5.00 Very Low Very Low Very Low
dexamethasone 3 5.00 Very Low Very Low Very Low
Opioid 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 10 99.30 Very High Very High Very High
Targeted Disruption 6 98.66 Very High Very High Very High
Jaundice 12 93.92 High High
Hyperbilirubinemia 45 92.48 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 122 70.04 Quite High
Van Bogaert's Disease 21 58.00 Quite High
Toxicity 12 58.00 Quite High
Gallstones 6 40.24 Quite Low
Hepatitis 8 23.20 Low Low
Sprains And Strains 8 11.60 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Differential modulation of UDP-glucuronosyltransferase 1A1 (UGT1A1)-catalyzed estradiol-3-glucuronidation by the addition of UGT1A1 substrates and other compounds to human liver microsomes.
Regulation (modulation) of UGT1A1 in liver
1) Confidence 0.60 Published 2002 Journal Drug Metab. Dispos. Section Title Doc Link 12386134 Disease Relevance 0 Pain Relevance 0.06
The underlying mechanism is an inhibition by ATV of the uridine-glucuronosyl-transferase (UGT) 1A1 enzyme, which is involved in bilirubin conjugation (Figure 2).35,36 In this context, genetic factors affecting ATV disposition and/or UGT1A1 function could alter bilirubin levels.
Regulation (affecting) of UGT1A1
2) Confidence 0.28 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697529 Disease Relevance 0.39 Pain Relevance 0
activation, and transgenic mice expressing the human UGT1 gene locus display transcriptional regulation of human UGT1A transgenes in liver and intestine by PPAR?.
Regulation (regulation) of UGT1A in intestine associated with targeted disruption
3) Confidence 0.24 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0.16 Pain Relevance 0.03
Other polymorphisms in the genes encoding for the UGT isoenzymes could also be associated with Gilbert’s syndrome.40,41 Lankisch et al examined the effects of different polymorphisms in UGT1A1 (UGT1A1*28), UGT1A3 (-66) and UGT1A7 (?
Spec (examined) Regulation (effects) of UGT1A1 associated with syndrome
4) Confidence 0.17 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697529 Disease Relevance 0.90 Pain Relevance 0
Therefore, as predicted by the bilirubin glucuronidation activity data, UGT1A1 is a target of PPAR?
Regulation (target) of UGT1A1
5) Confidence 0.15 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0 Pain Relevance 0
activation, and transgenic mice expressing the human UGT1 gene locus display transcriptional regulation of human UGT1A transgenes in liver and intestine by PPAR?.
Regulation (regulation) of UGT1A in liver associated with targeted disruption
6) Confidence 0.08 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0.16 Pain Relevance 0.03

General Comments

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