INT105898

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Context Info
Confidence 0.26
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.07
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
1A6 1
liver 1
internal 1
SLC45A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 18 99.48 Very High Very High Very High
Paracetamol 19 98.60 Very High Very High Very High
Morphine 2 61.48 Quite High
Disease Link Frequency Relevance Heat
Hepatotoxicity 2 75.00 Quite High
Reprotox - General 1 1 26.88 Quite Low
Toxicity 3 25.00 Low Low
Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Differential modulation of UDP-glucuronosyltransferase 1A1 (UGT1A1)-catalyzed estradiol-3-glucuronidation by the addition of UGT1A1 substrates and other compounds to human liver microsomes.
Regulation (modulation) of 1A1 in liver
1) Confidence 0.26 Published 2002 Journal Drug Metab. Dispos. Section Title Doc Link 12386134 Disease Relevance 0 Pain Relevance 0.06
The importance of uridine 5'-diphosphate-glucuronosyltranferases (UGT) 2B15 and other UGT enzymes (1A1, 1A6, and 1A9) in glucuronidating acetaminophen (APAP) is demonstrated.
Regulation (importance) of 1A1 in 1A6 associated with paracetamol
2) Confidence 0.26 Published 2006 Journal Chem. Res. Toxicol. Section Abstract Doc Link 16696573 Disease Relevance 0.07 Pain Relevance 0.69
MATP is invariant in Thoroughbred horses and was, therefore, used as an internal control.
Regulation (control) of MATP in internal
3) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996296 Disease Relevance 0 Pain Relevance 0.30

General Comments

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