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Context Info
Confidence 0.31
First Reported 2002
Last Reported 2004
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.34
Pain Relevance 1.67

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transmembrane transporter activity (SLC22A6, SLC22A8) plasma membrane (SLC22A6, SLC22A8) transmembrane transport (SLC22A6, SLC22A8)
protein complex (SLC22A6)
Anatomy Link Frequency
oocytes 1
SLC22A6 (Homo sapiens)
SLC22A8 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 16 99.76 Very High Very High Very High
methotrexate 8 97.56 Very High Very High Very High
diclofenac 1 89.60 High High
Paracetamol 1 87.92 High High
Disease Link Frequency Relevance Heat
Disease 1 95.36 Very High Very High Very High
INFLAMMATION 3 90.52 High High
Adverse Drug Reaction 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we examined the drug interaction via hOAT1 and hOAT3, using Xenopus laevis oocytes. hOAT1 and hOAT3 mediated the methotrexate transport with low affinity (K(m) of 724.0 muM) and high affinity (K(m) of 17.2 muM), respectively.
hOAT1 Spec (examined) Binding (interaction) of hOAT3 in oocytes associated with methotrexate
1) Confidence 0.31 Published 2004 Journal Drug Metab. Pharmacokinet. Section Abstract Doc Link 15548848 Disease Relevance 0.19 Pain Relevance 0.57
By comparing the IC(50) values of NSAIDs for hOATs, it was found that hOAT1 and hOAT3 exhibited higher affinity interactions with NSAIDs than did hOAT2 and hOAT4.
hOAT1 Binding (interactions) of hOAT3 associated with cinod
2) Confidence 0.01 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12388633 Disease Relevance 0.16 Pain Relevance 1.10

General Comments

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