INT105923

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Context Info
Confidence 0.14
First Reported 2002
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 34
Total Number 34
Disease Relevance 17.81
Pain Relevance 4.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (FUT1) Golgi apparatus (FUT1) carbohydrate metabolic process (FUT1)
Anatomy Link Frequency
kidney 4
blood 3
HSC 2
liver 1
tail vein 1
FUT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 43 99.76 Very High Very High Very High
cytokine 40 99.66 Very High Very High Very High
fibrosis 154 99.08 Very High Very High Very High
ischemia 49 97.80 Very High Very High Very High
alcohol 85 94.68 High High
antagonist 29 94.52 High High
aspirin 8 94.00 High High
Inflammation 159 89.08 High High
Pain 9 88.52 High High
Paracetamol 5 86.80 High High
Disease Link Frequency Relevance Heat
Cirrhosis 1191 100.00 Very High Very High Very High
Cancer 178 100.00 Very High Very High Very High
Primary Sclerosing Cholangitis 62 100.00 Very High Very High Very High
Myeloid Leukemia 64 99.80 Very High Very High Very High
Stress 124 99.78 Very High Very High Very High
Increased Venous Pressure Under Development 22 99.78 Very High Very High Very High
Injury 396 99.52 Very High Very High Very High
Fibrosis 142 99.52 Very High Very High Very High
Hepatotoxicity 15 98.66 Very High Very High Very High
Cv Unclassified Under Development 49 97.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Subsequently, we confirmed that after conjugation of the carriers with the lipophilic drug 15dPGJ2, the ability of both conjugates to bind rat HSC was preserved.
HSC Binding (bind) of associated with cirrhosis
1) Confidence 0.14 Published 2007 Journal Pharm Res Section Body Doc Link PMC1915609 Disease Relevance 0.19 Pain Relevance 0.03
Binding to HSC
HSC Binding (Binding) of associated with cirrhosis
2) Confidence 0.14 Published 2007 Journal Pharm Res Section Body Doc Link PMC1915609 Disease Relevance 0.53 Pain Relevance 0
To prevent passage dependent variations, third passages of PSC and HSC were used for all analyses.
HSC Binding (passages) of associated with cirrhosis and primary sclerosing cholangitis
3) Confidence 0.12 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2876060 Disease Relevance 0.27 Pain Relevance 0
In our studies, we showed that both conjugates were able to effectively reduce the viability of HSC in vitro.
HSC Binding (viability) of associated with cirrhosis
4) Confidence 0.12 Published 2007 Journal Pharm Res Section Body Doc Link PMC1915609 Disease Relevance 0.65 Pain Relevance 0
In contrast, binding of 15dPGJ2-pPBHSA to cultured HSC was not affected by polyinosinic acid, suggesting that scavenger receptors are not involved in the binding of pPBHSA to HSC.
HSC Binding (binding) of associated with cirrhosis
5) Confidence 0.12 Published 2007 Journal Pharm Res Section Body Doc Link PMC1915609 Disease Relevance 0.82 Pain Relevance 0
This observation can be due to the differences of HSC and PSC, or it could, considering the temporal sequence of events, merely reflect a shorter cancer-HSC interaction [30].
cancer-HSC Binding (interaction) of associated with cirrhosis, cancer and primary sclerosing cholangitis
6) Confidence 0.12 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2876060 Disease Relevance 2.60 Pain Relevance 0.26
After chemical conjugation of 15dPGJ2 to the carriers, the constructs displayed pharmacological activity and specific receptor-mediated binding to HSC in vitro.
HSC Binding (binding) of in HSC associated with cirrhosis
7) Confidence 0.11 Published 2007 Journal Pharm Res Section Abstract Doc Link PMC1915609 Disease Relevance 1.02 Pain Relevance 0.09
The results of separate experiments with three different HSC isolations are expressed as the mean?
HSC Binding (experiments) of associated with cirrhosis
8) Confidence 0.11 Published 2007 Journal Pharm Res Section Body Doc Link PMC1915609 Disease Relevance 0.58 Pain Relevance 0.08
receptor (pPBHSA) may be quite relevant, since PDGF-BB is the major cytokine involved in the proliferation of HSC during the fibrotic process, and the PDGF-?
HSC Binding (proliferation) of associated with fibrosis, cirrhosis and cytokine
9) Confidence 0.11 Published 2007 Journal Pharm Res Section Body Doc Link PMC1915609 Disease Relevance 1.52 Pain Relevance 0.13
The interaction with HSC as reported for the individual carriers (5,7) was preserved after coupling of 15dPGJ2 to these carriers.
HSC Binding (interaction) of associated with cirrhosis
10) Confidence 0.10 Published 2007 Journal Pharm Res Section Body Doc Link PMC1915609 Disease Relevance 0.50 Pain Relevance 0
Radioactive studies showed significant binding of both constructs to HSC in vitro (Fig. 1).
HSC Binding (binding) of associated with cirrhosis
11) Confidence 0.10 Published 2007 Journal Pharm Res Section Body Doc Link PMC1915609 Disease Relevance 0.20 Pain Relevance 0.03
In sharp contrast to studies in other injured organs, our results indicate that migration of HSC to the ischemic damaged kidney is not solely dependent on the SDF-1/CXCR4 signalling axis.



HSC Binding (migration) of in kidney
12) Confidence 0.07 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698094 Disease Relevance 0.12 Pain Relevance 0.04
The mechanisms that regulate the trafficking of HSC to the ischemic damaged kidney, however, remain unclear.
HSC Binding (trafficking) of in HSC
13) Confidence 0.07 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698094 Disease Relevance 0.32 Pain Relevance 0.04
In contrast to other studies [11,13,18,21], we were unable to significantly influence the migration of HSC to the ischemic injured kidney by blocking the SDF-1/CXCR4-axis.
HSC Neg (unable) Binding (migration) of in kidney
14) Confidence 0.07 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698094 Disease Relevance 0 Pain Relevance 0
In order to neutralize HSC-associated CXCR4, the same protocol was used as reported previously to be effective in blocking the recruitment of BMC [18] or HSC [11,13,18].
HSC Binding (recruitment) of
15) Confidence 0.07 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698094 Disease Relevance 0.25 Pain Relevance 0.03
SDF-1 and CXCR4-neutralizing antibodies inhibit HSC migration in vitro and in vivo
HSC Neg (inhibit) Binding (migration) of
16) Confidence 0.07 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698094 Disease Relevance 0.23 Pain Relevance 0.08
Migration of HSC is not prevented by blocking the SDF-1/CXCR4-axis
HSC Binding (Migration) of
17) Confidence 0.07 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698094 Disease Relevance 0.07 Pain Relevance 0
Despite this, we could not observe a significant effect of neutralizing SDF-1 or its receptor CXCR4 on the migration of HSC to the injured kidney.
HSC Binding (migration) of in kidney
18) Confidence 0.07 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698094 Disease Relevance 0.22 Pain Relevance 0
To validate whether anti-SDF-1 and anti-CXCR4 were also able to inhibit the migration of HSC in vivo, HSC were injected into the tail vein of naive mice with or without blocking either endogenous SDF-1 or HSC-associated CXCR4 with a monoclonal antibody as previously described [11,13,18,21].
HSC Binding (migration) of in tail vein
19) Confidence 0.07 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698094 Disease Relevance 0.21 Pain Relevance 0.06
This model gives the opportunity to compare the migration of HSC in injured and normal tissue within one mouse, in contrast to experimental models such as cisplatin-induced renal injury and bilateral renal I/R injury.
HSC Binding (migration) of associated with injury
20) Confidence 0.07 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698094 Disease Relevance 0.45 Pain Relevance 0.03

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