INT105938

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Context Info
Confidence 0.30
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.70
Pain Relevance 1.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
B cell 4
blood 2
Igh-6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
intrathecal 22 100.00 Very High Very High Very High
Inflammation 97 98.08 Very High Very High Very High
cytokine 43 97.04 Very High Very High Very High
Chronic pancreatitis 1 96.68 Very High Very High Very High
Arthritis 270 96.12 Very High Very High Very High
headache 2 95.72 Very High Very High Very High
methotrexate 50 91.00 High High
rheumatoid arthritis 55 69.36 Quite High
imagery 13 5.00 Very Low Very Low Very Low
cINOD 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 9 99.58 Very High Very High Very High
Arthritis 288 99.26 Very High Very High Very High
Pancreatitis 6 99.16 Very High Very High Very High
Eosinophilia 3 98.28 Very High Very High Very High
Pressure And Volume Under Development 52 98.20 Very High Very High Very High
INFLAMMATION 98 98.08 Very High Very High Very High
Headache 3 95.72 Very High Very High Very High
Vomiting 4 95.20 Very High Very High Very High
Fever 4 94.80 High High
Lumbar Puncture Related Headaches 4 88.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Infection with A. cantonensis produces a prominent intrathecal production of IgM, IgA and IgG seven to ten days after the beginning of symptoms as we have reported earlier [15].
Negative_regulation (produces) of Gene_expression (production) of IgM associated with infection and intrathecal
1) Confidence 0.30 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2607252 Disease Relevance 0.66 Pain Relevance 0.22
P. amboinicus significantly inhibited the footpad swelling and arthritic symptoms in collagen-induced arthritic rats, while the serum anti-collagen IgM and CRP levels were consistently decreased.
Negative_regulation (decreased) of Gene_expression (levels) of IgM associated with pressure and volume under development and arthritis
2) Confidence 0.24 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Abstract Doc Link PMC2816374 Disease Relevance 1.35 Pain Relevance 0.42
Previous research indicated that it could reduce immunoglobulin production by acting directly on B lymphocytes in both mice and humans, despite having no notable action on B-lymphocyte proliferation [1].
Negative_regulation (reduce) of Gene_expression (production) of immunoglobulin in B-lymphocyte
3) Confidence 0.23 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656239 Disease Relevance 0.73 Pain Relevance 0.35
B/T cell ratio was altered after phytol injection (Figure 3D), presumably through an increase of B cell number, because a tendency towards higher levels of IgG and IgM was also seen (Figure 3E).
Negative_regulation (tendency) of Gene_expression (levels) of IgM in B cell
4) Confidence 0.19 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1564167 Disease Relevance 0.28 Pain Relevance 0.05
Perna and DMG reduced anti-collagen IgM antibodies in rats
Negative_regulation (reduced) of Gene_expression (antibodies) of IgM
5) Confidence 0.08 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC1899520 Disease Relevance 0.86 Pain Relevance 0.23
RESULTS: A predominant absence of intrathecal immunoglobulin synthesis and two patients with IgA and IgM synthesis was produced. 66% of cerebrospinal blood barrier dysfunction, 6.26 10 3 mean albumin ratio, lactate below 2.1 mmol/L and glucose concentration in cerebrospinal fluid was 50% over glucose blood content and 168 cells 10 6 L mainly lymphocytes were observed.
Negative_regulation (absence) of Gene_expression (synthesis) of immunoglobulin in blood
6) Confidence 0.02 Published 2002 Journal Rev Neurol Section Body Doc Link 12389166 Disease Relevance 0.34 Pain Relevance 0
Decreased production of immunoglobulin M and A in autoimmune pancreatitis.
Negative_regulation (Decreased) of Gene_expression (production) of immunoglobulin M associated with pancreatitis
7) Confidence 0.00 Published 2009 Journal J. Gastroenterol. Section Title Doc Link 19626266 Disease Relevance 0.48 Pain Relevance 0.10

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