INT10594

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Context Info
Confidence 0.57
First Reported 1988
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 33
Total Number 34
Disease Relevance 6.00
Pain Relevance 3.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Dlst) plasma membrane (Dlst) nucleus (Dlst)
transferase activity, transferring acyl groups (Dlst) cytoplasm (Dlst)
Anatomy Link Frequency
plasma 4
uterus 4
stroma 1
mammary gland 1
peritoneum 1
Dlst (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 21 99.56 Very High Very High Very High
Clonidine 8 99.56 Very High Very High Very High
endometriosis 336 99.44 Very High Very High Very High
anesthesia 37 88.24 High High
Dismenorea 14 86.28 High High
Dynorphin 1 86.04 High High
agonist 40 84.44 Quite High
medulla 1 76.76 Quite High
antagonist 16 75.00 Quite High
opiate 8 75.00 Quite High
Disease Link Frequency Relevance Heat
Endometriosis 448 99.44 Very High Very High Very High
Cancer 73 96.80 Very High Very High Very High
Body Weight 100 93.12 High High
Repression 17 90.72 High High
Hyperplasia 42 88.40 High High
Reprotox - General 3 46 86.92 High High
Reprotox - General 1 15 86.28 High High
Gynecological Disease 3 84.80 Quite High
Metaplasia 20 81.12 Quite High
Endometriosis (extended) 39 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since P4 and androgens are precursors in the synthesis of E2, we presume that this mechanism may explain the increase in E2 serum concentrations observed in rats with peritoneum perforation previously injected with ATR.
Gene_expression (synthesis) of E2 in peritoneum
1) Confidence 0.57 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1564398 Disease Relevance 0.14 Pain Relevance 0.09
At 12 days after OVX, 100% of CR showed detectable pulses at all doses of E2, while 100, 60, 50 and 17% of UR had detectable pulses at 0, 1.2, 2.4 and 4.8 micrograms doses of E2, respectively.
Gene_expression (doses) of E2
2) Confidence 0.54 Published 1991 Journal Neuroendocrinology Section Abstract Doc Link 2041586 Disease Relevance 0 Pain Relevance 0.08
Estradiol (E2) replacement through sc SILASTIC implants for 1, 3, 7, and 14 days, which produces serum E2 levels between 25-35 pg/ml, restored in a time-dependent manner mRNA and peptide concentrations to values in sham-OVX rats.
Gene_expression (produces) of E2
3) Confidence 0.46 Published 1995 Journal Endocrinology Section Abstract Doc Link 7895668 Disease Relevance 0 Pain Relevance 0.04
However, the E2-pellet treatment produced plasma E2 levels that were 2-fold greater than the E2 levels produced by multiple injections of E2-CDS.
Gene_expression (produced) of E2 in plasma
4) Confidence 0.42 Published 1991 Journal Maturitas Section Abstract Doc Link 1907349 Disease Relevance 0.42 Pain Relevance 0.14
However, the E2-pellet treatment produced plasma E2 levels that were 2-fold greater than the E2 levels produced by multiple injections of E2-CDS.
Gene_expression (produced) of E2 in plasma
5) Confidence 0.42 Published 1991 Journal Maturitas Section Abstract Doc Link 1907349 Disease Relevance 0.48 Pain Relevance 0.17
Plasma gonadotropins (LH and FSH) were significantly suppressed with the E2-pellet as well as the single and multiple E2-CDS treatment.
Gene_expression (suppressed) of E2 in Plasma
6) Confidence 0.41 Published 1991 Journal Maturitas Section Abstract Doc Link 1907349 Disease Relevance 0.40 Pain Relevance 0.13
The clearest finding that GEN does not act exactly the same as E2 was found in the vaginal epithelium, where GEN high induced a different feature: cytoplasmatic vacuolization.



Gene_expression (found) of E2 in epithelium
7) Confidence 0.37 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2174401 Disease Relevance 0.06 Pain Relevance 0
We observed this pattern in one-half of the GEN low animals, in all GEN high animals, and in both E2 groups; in the controls, cells remained round and densely packed.
Gene_expression (groups) of E2
8) Confidence 0.37 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2174401 Disease Relevance 0.11 Pain Relevance 0
We observed changes like these mainly in the E2 low and GEN high animals.
Gene_expression (low) of E2
9) Confidence 0.32 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2174401 Disease Relevance 0.29 Pain Relevance 0
Therefore, we performed proliferation-specific analyses and determined expression of the progesterone receptor (PR), which is stimulated in the mammary gland after E2 exposure (Tekmal et al. 2005).
Gene_expression (exposure) of E2 in mammary gland
10) Confidence 0.32 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2174401 Disease Relevance 0.22 Pain Relevance 0.15
Serum E2 levels in controls and E2-treated animals are shown in Figure 1A.
Gene_expression (levels) of E2
11) Confidence 0.29 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2174401 Disease Relevance 0.09 Pain Relevance 0
Serum E2 concentrations were barely detectable in control animals, whereas they were in physiologic range in the E2 low group and at supra-physiologic levels in the E2 high group.
Gene_expression (detectable) of E2
12) Confidence 0.29 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2174401 Disease Relevance 0.14 Pain Relevance 0
Verapamil had a action to produce significantly E2 with a slight production of DHT, and naloxone showed a significant production of both DHT and E2.
Gene_expression (production) of E2 associated with narcan
13) Confidence 0.28 Published 1992 Journal J Toxicol Sci Section Abstract Doc Link 1507273 Disease Relevance 0.13 Pain Relevance 0.36
One possible mechanism may relate to E2 enhancing brain nNOS expression and activity.
Gene_expression (expression) of E2 in brain
14) Confidence 0.25 Published 1998 Journal Neuroreport Section Abstract Doc Link 9831465 Disease Relevance 0.17 Pain Relevance 0.14
Ketoconazole had a significant production of both delta 4-androstenedione (delta 4-A) and E2 while it had a significant inhibition of DHT-production, thus this had a significant production of both aromatase and C17,20-lyase while had a significant inhibitory action of 5 alpha-reductase.
Gene_expression (production) of E2
15) Confidence 0.25 Published 1992 Journal J Toxicol Sci Section Abstract Doc Link 1507273 Disease Relevance 0.13 Pain Relevance 0.35
Verapamil had a action to produce significantly E2 with a slight production of DHT, and naloxone showed a significant production of both DHT and E2.
Gene_expression (produce) of E2 associated with narcan
16) Confidence 0.22 Published 1992 Journal J Toxicol Sci Section Abstract Doc Link 1507273 Disease Relevance 0.19 Pain Relevance 0.45
Prazosin had a tendency to produce dihydrotestosterone (DHT) indicating a facilitation of 5 alpha-reductase, and clonidine showed a significant production of estradiol (E2) with a slight production of DHT indicating a significant facilitation of aromatase.
Gene_expression (production) of E2 associated with clonidine
17) Confidence 0.22 Published 1992 Journal J Toxicol Sci Section Abstract Doc Link 1507273 Disease Relevance 0.20 Pain Relevance 0.47
To confirm altered gene expression profile by E2 or EDs in the uterus of immature rats, adult female rats were also employed to examine the elevated endogenous E2 in the induction of these genes at proestrus and estrus during estrous cycle.
Gene_expression (expression) of E2 in uterus
18) Confidence 0.16 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1594574 Disease Relevance 0 Pain Relevance 0
E2 is a major factor controlling CaBP-9k gene expression in the rat uterus.
Gene_expression (expression) of E2 in uterus
19) Confidence 0.14 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1594574 Disease Relevance 0 Pain Relevance 0.06
To confirm altered gene expression profile by E2 or EDs in the uterus of immature rats, adult female rats were also employed to examine the elevated endogenous E2 in the induction of these genes at proestrus and estrus during estrous cycle.
Gene_expression (expression) of E2 in uterus
20) Confidence 0.14 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1594574 Disease Relevance 0 Pain Relevance 0

General Comments

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