INT105948

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Context Info
Confidence 0.65
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 4.26
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (AURKA) cytosol (AURKA) mitosis (AURKA)
nucleus (AURKA) cytoskeleton (AURKA) cell cycle (AURKA)
AURKA (Homo sapiens)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 1 56.96 Quite High
Migraine 6 50.00 Quite Low
Inflammation 4 50.00 Quite Low
cytokine 2 50.00 Quite Low
imagery 17 37.56 Quite Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
pain pelvic 2 5.00 Very Low Very Low Very Low
drug abuse 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aggression 95 100.00 Very High Very High Very High
Endometrial Cancer 306 99.64 Very High Very High Very High
Aneuploidy 6 98.28 Very High Very High Very High
Malignant Neoplastic Disease 38 97.64 Very High Very High Very High
Cancer 268 88.36 High High
Breast Cancer 167 78.20 Quite High
Microsatellite Instability 94 72.88 Quite High
Apoptosis 35 72.04 Quite High
Congenital Anomalies 4 65.08 Quite High
Noninfiltrating Intraductal Carcinoma 21 63.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSION: The results of our study suggest that current IHS diagnostic criteria for MA may lead to an overestimation of MA cases.


Gene_expression (overestimation) of MA
1) Confidence 0.65 Published 2002 Journal Headache Section Body Doc Link 12390623 Disease Relevance 0.11 Pain Relevance 0
Differences in the distribution of the allele frequencies were also observed, being the TNF-alpha-308 G allele overrepresented in control group and TNF-alpha-308 A allele in MwoA group.
Gene_expression (group) of MwoA
2) Confidence 0.65 Published 2010 Journal Pain Med Section Body Doc Link 20113413 Disease Relevance 0 Pain Relevance 0
When an individual answers "no" to all of the HARK questions the likelihood ratio and post test odds (0.2 and 0.1 respectively) suggest that IPV is probably not present; whereas answering "yes" to three or four HARK questions produces a specificity of 100%, meaning that IPV is present.
Neg (not) Gene_expression (present) of HARK associated with aggression
3) Confidence 0.65 Published 2007 Journal BMC Fam Pract Section Body Doc Link PMC2034562 Disease Relevance 0.94 Pain Relevance 0
Overexpression of STK15 induces increased numbers of centrosomes, aneuploidy, and malignant transformation.
Gene_expression (Overexpression) of STK15 associated with malignant neoplastic disease and aneuploidy
4) Confidence 0.43 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.45 Pain Relevance 0
Intestinal trefoil protein, TFF3, AGR2 developmental gene, estrogen-regulated genes (MGB2, LTF, END1, MMP11), FOXA2, and MSX2 were significantly up-regulated in endometrioid endometrial carcinomas, while increased expression of FOLR, genes involved in the regulation of mitotic spindle checkpoint (STK15, BUB1, CCNB2), IGF2, PTGS1 and p16 were seen in non-endometrioid endometrial carcinomas.
Gene_expression (expression) of STK15 associated with endometrial cancer
5) Confidence 0.34 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.40 Pain Relevance 0
Equally, several studies have indicated the importance of considering specific lesions in relation to therapeutic response, for example, Aurora kinase overexpression and taxane resistance, BRCA2 loss and response to platinum-based therapy [67], topoisomerase II alpha amplification and epirubicin response [68].
Gene_expression (overexpression) of Aurora kinase
6) Confidence 0.06 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2397525 Disease Relevance 0.35 Pain Relevance 0.03

General Comments

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