INT105949

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Context Info
Confidence 0.49
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.91
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (AURKA) cytosol (AURKA) mitosis (AURKA)
nucleus (AURKA) cytoskeleton (AURKA) cell cycle (AURKA)
AURKA (Homo sapiens)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 1 56.96 Quite High
Migraine 3 50.00 Quite Low
imagery 17 37.56 Quite Low
palliative 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
pain pelvic 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aneuploidy 3 98.28 Very High Very High Very High
Malignant Neoplastic Disease 20 97.64 Very High Very High Very High
Endometrial Cancer 153 94.00 High High
Cancer 182 88.36 High High
Breast Cancer 167 78.20 Quite High
Microsatellite Instability 47 72.88 Quite High
Noninfiltrating Intraductal Carcinoma 21 63.00 Quite High
Apoptosis 19 58.96 Quite High
Migraine With Aura 1 54.32 Quite High
Headache 1 52.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSION: The results of our study suggest that current IHS diagnostic criteria for MA may lead to an overestimation of MA cases.


Positive_regulation (overestimation) of Gene_expression (overestimation) of MA
1) Confidence 0.49 Published 2002 Journal Headache Section Body Doc Link 12390623 Disease Relevance 0.11 Pain Relevance 0
Overexpression of STK15 induces increased numbers of centrosomes, aneuploidy, and malignant transformation.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of STK15 associated with malignant neoplastic disease and aneuploidy
2) Confidence 0.39 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.45 Pain Relevance 0
Equally, several studies have indicated the importance of considering specific lesions in relation to therapeutic response, for example, Aurora kinase overexpression and taxane resistance, BRCA2 loss and response to platinum-based therapy [67], topoisomerase II alpha amplification and epirubicin response [68].
Positive_regulation (overexpression) of Gene_expression (overexpression) of Aurora kinase
3) Confidence 0.04 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2397525 Disease Relevance 0.35 Pain Relevance 0.03

General Comments

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