INT105959

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Context Info
Confidence 0.49
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.65
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cdh1) cell adhesion (Cdh1) Golgi apparatus (Cdh1)
plasma membrane (Cdh1) cytoplasm (Cdh1)
Cdh1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 3 96.76 Very High Very High Very High
cINOD 11 87.96 High High
Inflammation 11 57.28 Quite High
COX-2 inhibitor 1 36.40 Quite Low
imagery 13 10.56 Low Low
cytokine 13 5.00 Very Low Very Low Very Low
Crohn's disease 9 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 125 99.48 Very High Very High Very High
Skin Cancer 11 97.80 Very High Very High Very High
Non-small-cell Lung Cancer 6 97.76 Very High Very High Very High
Celiac Disease 13 94.64 High High
Small Cell Lung Cancer 1 93.20 High High
Congenital Anomalies 8 78.56 Quite High
Rhinitis 1 77.12 Quite High
Lung Cancer 34 75.00 Quite High
INFLAMMATION 16 75.00 Quite High
Carcinoma 9 74.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In induced Cre+Cdh1fl/fl mice staining of the Wnt target gene EphB3 appeared unchanged at the base of the crypts compared to controls (Fig. 6A and not shown).
Positive_regulation (induced) of Gene_expression (staining) of Cdh1fl
1) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0 Pain Relevance 0
Our results support the hypothesis that both gluten and indomethacin play a role in the expression of E-cadherin, and that this effect is potentiated in a genetically susceptible host when both agents are administered together.
Positive_regulation (role) of Gene_expression (expression) of E-cadherin
2) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2715133 Disease Relevance 0.34 Pain Relevance 0.03
Increased expression of PPARgamma, as well as ciglitazone and sulindac sulfide induced expression of E-cadherin, which has been linked to increased differentiation of NSCLC.
Positive_regulation (induced) of Gene_expression (expression) of E-cadherin associated with non-small-cell lung cancer
3) Confidence 0.24 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 12391285 Disease Relevance 0.93 Pain Relevance 0.54
Furthermore, immunohistochemical staining of s.c. primary tumours of SPC-A-1sci cells also confirmed the remarkably reduced expression of E-cadherin (Fig. 2D).
Positive_regulation (confirmed) of Gene_expression (expression) of E-cadherin associated with cancer
4) Confidence 0.10 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2912267 Disease Relevance 0.25 Pain Relevance 0
USC-HN1 cells demonstrate strong, uniform nuclear p53 and Rb expression, as well as positive expression of keratin, E-cadherin, EGFr, and CD44 in situ consistent with HNSCC as well as the original tumor biopsy [4,7,13,19].
Positive_regulation (nuclear) of Gene_expression (expression) of E-cadherin associated with cancer
5) Confidence 0.08 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2841166 Disease Relevance 1.13 Pain Relevance 0

General Comments

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