INT10596

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Context Info
Confidence 0.42
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 2.08
Pain Relevance 1.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cyp19a1) endoplasmic reticulum (Cyp19a1) cytoplasm (Cyp19a1)
Cyp19a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 53 99.98 Very High Very High Very High
Clonidine 4 97.84 Very High Very High Very High
narcan 6 96.68 Very High Very High Very High
Dopamine 8 83.04 Quite High
antagonist 45 75.00 Quite High
opiate 6 75.00 Quite High
Catecholamine 8 71.44 Quite High
Pain 20 60.04 Quite High
headache 5 59.84 Quite High
IPN 1 55.60 Quite High
Disease Link Frequency Relevance Heat
Endometriosis (extended) 16 98.00 Very High Very High Very High
Recurrence 11 91.68 High High
Breast Cancer 11 90.76 High High
Disease 24 87.28 High High
Disorder Of Lipid Metabolism 3 87.24 High High
Reprotox - General 2 5 77.64 Quite High
Congenital Anomalies 17 76.32 Quite High
Fungal Infection 4 75.00 Quite High
Toxicity 16 74.04 Quite High
Hyperplasia 2 64.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A prospective open label randomized multicenter substudy was performed in the German TEAM Trial Group to test the hypothesis that the irreversible inactivation of aromatase by exemestane (EXE; N = 78) would result in less endometrial proliferation than tamoxifen (TAM; N = 65) (Kieback et al 2006).
Positive_regulation (inactivation) of aromatase associated with endometriosis (extended)
1) Confidence 0.42 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2643110 Disease Relevance 0.67 Pain Relevance 0
Prazosin had a tendency to produce dihydrotestosterone (DHT) indicating a facilitation of 5 alpha-reductase, and clonidine showed a significant production of estradiol (E2) with a slight production of DHT indicating a significant facilitation of aromatase.
Positive_regulation (facilitation) of aromatase associated with clonidine
2) Confidence 0.40 Published 1992 Journal J Toxicol Sci Section Abstract Doc Link 1507273 Disease Relevance 0.20 Pain Relevance 0.46
A key role of aromatase is local production of estrogens, which are essential for the maintenance of bone integrity [27].
Positive_regulation (role) of aromatase
3) Confidence 0.36 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206728 Disease Relevance 0.89 Pain Relevance 0.06
Thus, these two agents showed facilitation of both 5 alpha-reductase and aromatase.
Positive_regulation (facilitation) of aromatase
4) Confidence 0.35 Published 1992 Journal J Toxicol Sci Section Abstract Doc Link 1507273 Disease Relevance 0.13 Pain Relevance 0.36
In agreement with the previous data and with our initial hypothesis, we showed in the present experiment that a single s.c. injection of morphine changed the aromatase activity in two of the three tissues taken into account, strongly indicating an increase of the catabolic activity of testosterone at least in these tissues.
Positive_regulation (changed) of aromatase associated with morphine
5) Confidence 0.30 Published 2010 Journal Mol Pain Section Body Doc Link PMC2978140 Disease Relevance 0.19 Pain Relevance 0.42
Aromatase induction is a physiological mechanism to deactivate xenobiotics, which does not inevitably cause a toxic effect.
Positive_regulation (induction) of Aromatase
6) Confidence 0.24 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1524969 Disease Relevance 0 Pain Relevance 0
For p,p-DDE, the induction of aromatase has been demonstrated in vitro and in vivo [30].
Positive_regulation (induction) of aromatase
7) Confidence 0.24 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1524969 Disease Relevance 0 Pain Relevance 0.10
In addition, the pesticides methomyl, pirimicarb, propamocarb, and iprodion can weakly stimulate aromatase activity [31], whereas heptachlor may act as an inducer of testosterone 16-alpha and 16-beta hydroxylases [32].
Positive_regulation (stimulate) of aromatase
8) Confidence 0.16 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1524969 Disease Relevance 0 Pain Relevance 0.12
The pesticides atrazine, simazine, and propazine (2-chloro-triazine herbicides) induce aromatase activity in vitro [29].
Positive_regulation (induce) of aromatase
9) Confidence 0.16 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1524969 Disease Relevance 0 Pain Relevance 0.09
-diol, can upregulate aromatase activity, which may account for these differences [32]; there is, however, little definitive evidence for the regulation of the ejaculatory reflex by E2 in Syrian hamsters.
Positive_regulation (upregulate) of aromatase
10) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939075 Disease Relevance 0 Pain Relevance 0.03

General Comments

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