INT105960

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.76
First Reported 2002
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 41
Total Number 56
Disease Relevance 22.28
Pain Relevance 5.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cdh1) cell adhesion (Cdh1) Golgi apparatus (Cdh1)
plasma membrane (Cdh1) cytoplasm (Cdh1)
Anatomy Link Frequency
goblet cells 5
brush 3
intestinal epithelium 2
epithelium 2
endometrium 2
Cdh1 (Mus musculus)
Pain Link Frequency Relevance Heat
Calcium channel 132 100.00 Very High Very High Very High
Nicotine 121 99.46 Very High Very High Very High
metalloproteinase 10 99.30 Very High Very High Very High
Dismenorea 28 98.98 Very High Very High Very High
Crohn's disease 144 98.36 Very High Very High Very High
agonist 17 96.44 Very High Very High Very High
cytokine 223 95.60 Very High Very High Very High
Inflammation 151 92.88 High High
addiction 18 92.76 High High
cINOD 79 91.04 High High
Disease Link Frequency Relevance Heat
Adhesions 173 100.00 Very High Very High Very High
Targeted Disruption 61 99.88 Very High Very High Very High
Cancer 740 99.56 Very High Very High Very High
Dysmenorrhea 28 98.98 Very High Very High Very High
Celiac Disease 52 98.84 Very High Very High Very High
Infection 405 98.68 Very High Very High Very High
Pathologic Processes 18 98.40 Very High Very High Very High
Malignant Neoplastic Disease 91 98.16 Very High Very High Very High
Disease 321 98.04 Very High Very High Very High
Non-small-cell Lung Cancer 30 97.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of E-cadherin was reduced (Fig. 4C and D).
Gene_expression (Expression) of E-cadherin
1) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.09 Pain Relevance 0
We report here that loss of E-cadherin expression results in loss of adherens junctions and desmosomes, leading to apoptosis and shedding of cells.
Gene_expression (expression) of E-cadherin associated with apoptosis
2) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.62 Pain Relevance 0.06
Another study by the same authors analyzed mouse intestinal epithelium over-expressing of E-cadherin [47].
Gene_expression (expressing) of E-cadherin in intestinal epithelium
3) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.36 Pain Relevance 0.03
The simultaneous appearance of incompletely differentiated, mispositioned cells and of normally differentiated cells is most likely due to the coexistence of E-cadherin deficient and E-cadherin expressing cells owing to incomplete recombination in the extended tamoxifen injection protocol.
Gene_expression (expressing) of E-cadherin
4) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.11 Pain Relevance 0
Co-immunofluorescence studies for Muc2 (Fig. 7E and I), lysozyme (Fig. 7F and J), and E-cadherin (Fig. 7G and K) in control (Fig. 7E–H) and Cre+Cdh1fl/fl mice (Fig. 7I–L) revealed cells in the villi simultaneously expressing markers of Paneth and goblet cells and lacking expression of E-cadherin (Fig.7L).
Gene_expression (expression) of E-cadherin in goblet cells
5) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.07 Pain Relevance 0
Impaired expression of E-cadherin in the small intestine and colon has been linked to a disturbed intestinal homeostasis and barrier function.
Gene_expression (expression) of E-cadherin in colon
6) Confidence 0.76 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3001873 Disease Relevance 0.28 Pain Relevance 0.04
Several studies have reported reduced expression of E-cadherin in inflamed epithelium of patients with Crohn's disease and ulcerative colitis [8]–[10].
Gene_expression (expression) of E-cadherin in epithelium associated with inflammatory bowel disease, crohn's disease and disease
7) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.60 Pain Relevance 0.13
Therefore, loss of E-cadherin expression is likely to result in the dissociation of Rac1 which may explain the disturbed maturation and positioning of Paneth and goblet cells observed.
Gene_expression (expression) of E-cadherin in goblet cells
8) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.15 Pain Relevance 0
The simultaneous appearance of incompletely differentiated, mispositioned cells and of normally differentiated cells is most likely due to the coexistence of E-cadherin deficient and E-cadherin expressing cells owing to incomplete recombination in the extended tamoxifen injection protocol.
Gene_expression (expressing) of E-cadherin
9) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.11 Pain Relevance 0
The stronger effect in colon was also true for the milder recombination protocol: In colon, expression of E-cadherin was almost completely lost, whereas in small intestine, expression was strongly reduced but not lost.
Gene_expression (expression) of E-cadherin in small intestine
10) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.32 Pain Relevance 0.05
In vitro the RM1 cells express E-cadherin but not vimentin, do not form colonies in soft agar, are non-invasive but are more motile than the parent cell line.
Neg (not) Gene_expression (express) of E-cadherin
11) Confidence 0.72 Published 2009 Journal Prostate Section Body Doc Link 19585491 Disease Relevance 0.14 Pain Relevance 0
Moreover, during progression of colorectal and other tumors a switch in cadherin expression from E-cadherin to N-cadherin is observed coinciding with the transition from an epithelial to a mesenchymal phenotype leading to an increase in the invasive capabilities of cancer cells [6] and inactivation of one E-cadherin allele enhances tumor initiation in mice carrying a mutated adenomatous polyposis coli (APC) gene [13].
Gene_expression (expression) of E-cadherin associated with cancer and familial adenomatous polyposis
12) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.89 Pain Relevance 0.13
The simultaneous appearance of incompletely differentiated, mispositioned cells and of normally differentiated cells is most likely due to the coexistence of E-cadherin deficient and E-cadherin expressing cells owing to incomplete recombination in the extended tamoxifen injection protocol.
Gene_expression (deficient) of E-cadherin
13) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.10 Pain Relevance 0
E-cadherin functions as a survival factor for the small intestinal and colonic epithelium and its expression is a prerequisite for the maintenance of the epithelial defense function.
Gene_expression (expression) of E-cadherin in epithelium
14) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.72 Pain Relevance 0.24
In induced Cre+Cdh1fl/fl mice staining of the Wnt target gene EphB3 appeared unchanged at the base of the crypts compared to controls (Fig. 6A and not shown).
Gene_expression (staining) of Cdh1fl
15) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0 Pain Relevance 0
Targeted deletion of the E-cadherin interacting protein p120-catenin led to a disrupted intestinal barrier and impaired epithelial homeostasis [15].
Gene_expression (deletion) of E-cadherin in p120
16) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.30 Pain Relevance 0
Briefly, 1 mg poly-A+ RNA, extracted from seabass brain, was reversed transcribed using 200 U M-MLV reverse transcriptase (Invitrogen, S.
Gene_expression (using) of U M in brain
17) Confidence 0.65 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2829032 Disease Relevance 0 Pain Relevance 0
In adenomyosis, the serum E2 level was negatively correlated with E-cadherin expression in the epithelial components of the eutopic endometrium and adenomyotic lesions, suggesting the involvement of oestrogen-induced EMT in endometrial cells.
Gene_expression (expression) of E-cadherin in endometrium associated with dismenorea
18) Confidence 0.60 Published 2010 Journal J. Pathol. Section Abstract Doc Link 20814901 Disease Relevance 0.91 Pain Relevance 0.84
In the epithelial component of adenomyotic lesions, vimentin expression was up-regulated and E-cadherin expression was down-regulated compared to the eutopic endometrium, suggesting that EMT occurs in adenomyosis.
Gene_expression (expression) of E-cadherin in endometrium associated with dismenorea
19) Confidence 0.60 Published 2010 Journal J. Pathol. Section Abstract Doc Link 20814901 Disease Relevance 0.93 Pain Relevance 0.86
Gluten-sensitized and indomethacin alone-treated mice showed reduced E-cadherin RNA expression by a mean factor of 0.762 and 0.533 respectively, but this did not achieve statistical difference relative to non-sensitized controls (Figure 4).
Gene_expression (expression) of E-cadherin
20) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2715133 Disease Relevance 0.06 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox