INT105969

Context Info Confidence 0.20 First Reported 2002 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 4 Disease Relevance 2.73 Pain Relevance 1.06

nucleus (SHOX)

SHOX (Homo sapiens)

Pain Link Frequency Relevance Heat Somatostatin 4 100.00 Paresthesia 4 99.84 Pain 23 99.24 Clonidine 1 68.48 agonist 1 65.12 carpal tunnel syndrome 28 59.32 Action potential 5 5.00 medulla 4 5.00 Migraine 3 5.00 depression 2 5.00

Disease Link Frequency Relevance Heat Dysesthesia 4 99.84 Pain 22 99.24 Aging 5 92.24 Hypesthesia 6 89.12 Diabetes Mellitus 4 87.04 Disease 15 85.76 Trigger Finger Disorder 8 82.32 Injury 4 74.00 Carpal Tunnel Syndrome 62 68.60 Cognitive Disorder 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The DASH and CTSI-SS are affected more by functional changes, whereas the CTSI-SS is affected by paresthesia or pain (or both), which can improve soon after surgery.

Regulation (affected) of CTSI-SS associated with pain and paresthesia

1) Confidence 0.20 Published 2007 Journal J Orthop Sci Section Body Doc Link PMC2778722 Disease Relevance 1.23 Pain Relevance 0.39

The limitations imposed on SS studies by a uniform repetition-rate are avoided in QSD [14].

Regulation (imposed) of SS

2) Confidence 0.16 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1483834 Disease Relevance 0 Pain Relevance 0

The DASH and CTSI-SS are affected more by functional changes, whereas the CTSI-SS is affected by paresthesia or pain (or both), which can improve soon after surgery.

Regulation (affected) of CTSI-SS associated with pain and paresthesia

3) Confidence 0.09 Published 2007 Journal J Orthop Sci Section Body Doc Link PMC2778722 Disease Relevance 1.24 Pain Relevance 0.40

Rather, age-related changes involving the function of specific hypothalamic peptides for GH regulation, GH-releasing hormone (GHRH) and somatostatin (SS), appear to be the fundamental factors.

Regulation (regulation) of SS associated with somatostatin

4) Confidence 0.01 Published 2002 Journal Neurobiol. Aging Section Abstract Doc Link 12392795 Disease Relevance 0.26 Pain Relevance 0.27

General Comments

This test has worked.