INT105974

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Context Info
Confidence 0.67
First Reported 2002
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 43
Total Number 43
Disease Relevance 23.47
Pain Relevance 4.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PRKAB1) signal transduction (PRKAB1) nucleus (PRKAB1)
Anatomy Link Frequency
colon 3
skeletal muscle 3
muscle 2
vastus lateralis 2
muscle cells 2
PRKAB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 35 100.00 Very High Very High Very High
qutenza 46 99.42 Very High Very High Very High
ischemia 11 99.12 Very High Very High Very High
adenocard 21 99.06 Very High Very High Very High
local anesthetic 88 93.48 High High
alcohol 97 84.12 Quite High
agonist 92 80.40 Quite High
Angina 59 79.44 Quite High
addiction 13 76.16 Quite High
tolerance 46 62.28 Quite High
Disease Link Frequency Relevance Heat
Colon Cancer 56 99.84 Very High Very High Very High
Helminth Infection 344 99.80 Very High Very High Very High
Apoptosis 431 99.68 Very High Very High Very High
Lifespan 264 99.28 Very High Very High Very High
Obesity 242 99.22 Very High Very High Very High
Cv Unclassified Under Development 21 99.12 Very High Very High Very High
Diabetes Mellitus 341 98.80 Very High Very High Very High
Disorder Of Lipid Metabolism 49 98.56 Very High Very High Very High
Insulin Resistance 102 98.52 Very High Very High Very High
Aging 95 98.42 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Concomitantly, the activation of AMPK and the increased expression of the inactive form of acetyl-CoA carboxylase (ACC) were detected in capsaicin-treated colon cancer cells.
Positive_regulation (activation) of AMPK in colon associated with qutenza and colon cancer
1) Confidence 0.67 Published 2007 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 17404062 Disease Relevance 1.21 Pain Relevance 0.70
Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is activated during ATP-depleting metabolic states, such as hypoxia, heat shock, oxidative stress, and exercise.
Positive_regulation (activated) of AMPK associated with stress, adenocard, hypoxia and shock
2) Confidence 0.67 Published 2007 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 17404062 Disease Relevance 0.74 Pain Relevance 0.30
We have investigated the effects of genistein, EGCG, and capsaicin on adipocyte differentiation in relation to AMPK activation in 3T3-L1 cells.
Positive_regulation (activation) of AMPK in 3T3-L1 associated with qutenza
3) Confidence 0.64 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16236247 Disease Relevance 0.49 Pain Relevance 0.33
The R225Q mutation produced a fully dominant protein [7] with increased AMPK activity.
Positive_regulation (increased) of AMPK
4) Confidence 0.50 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1964808 Disease Relevance 0.12 Pain Relevance 0.03
In this article, we have investigated the effects of capsaicin on apoptosis in relation to AMPK activation in colon cancer cell.
Positive_regulation (activation) of AMPK in colon associated with qutenza, colon cancer and apoptosis
5) Confidence 0.45 Published 2007 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 17404062 Disease Relevance 1.12 Pain Relevance 0.55
ACC phosphorylation was increased in the basal state as well as after stimulation with AICAR (an artificial activator of AMPK), indicating that the mutated AMPK could be activated [7].
Positive_regulation (activated) of AMPK
6) Confidence 0.44 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1964808 Disease Relevance 0.13 Pain Relevance 0.03
Evidence of the association between AMPK activation and the increased apoptosis in HT-29 colon cancer cells by capsaicin treatment, and further findings of the correlation of the activated AMPK and the elevated apoptosis by cotreatment of AICAR and capsaicin support AMPK as an important component of apoptosis, as well as a possible target of cancer control.
Positive_regulation (activated) of AMPK in colon associated with qutenza, cancer, colon cancer and apoptosis
7) Confidence 0.39 Published 2007 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 17404062 Disease Relevance 1.34 Pain Relevance 0.66
Genistein, EGCG, and capsaicin stimulated the intracellular ROS release, which activated AMPK rapidly.
Positive_regulation (activated) of AMPK associated with qutenza
8) Confidence 0.37 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16236247 Disease Relevance 0.47 Pain Relevance 0.35
We demonstrate in differentiated muscle satellite cells obtained from the vastus lateralis of R225W carriers that the mutation is associated with an approximate doubling of both basal and AMP-activated AMPK activities.
Positive_regulation (activated) of AMPK in vastus lateralis
9) Confidence 0.36 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC1964808 Disease Relevance 0.32 Pain Relevance 0
We have demonstrated that the R225W mutation increases basal and AMP-activated AMPK activities in differentiated muscle cells obtained from the vastus lateralis of carriers (Figure 3), and that ?
Positive_regulation (activated) of AMPK in muscle cells
10) Confidence 0.36 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1964808 Disease Relevance 0 Pain Relevance 0
ACC phosphorylation was increased in the basal state as well as after stimulation with AICAR (an artificial activator of AMPK), indicating that the mutated AMPK could be activated [7].
Positive_regulation (activator) of AMPK
11) Confidence 0.36 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1964808 Disease Relevance 0.13 Pain Relevance 0.03
Although R225W carriers demonstrate twice the AMP-stimulated AMPK activity of control subjects, the similar percent increases indicate that R225W AMPK is likely activated by AMP with a similar magnitude to control AMPK.
Positive_regulation (stimulated) of AMPK
12) Confidence 0.36 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1964808 Disease Relevance 0 Pain Relevance 0
We have demonstrated that the R225W mutation increases basal and AMP-activated AMPK activities in differentiated muscle cells obtained from the vastus lateralis of carriers (Figure 3), and that ?
Positive_regulation (increases) of AMPK in muscle cells
13) Confidence 0.36 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1964808 Disease Relevance 0 Pain Relevance 0
In skeletal muscle, AMPK activation stimulates glucose uptake, fatty acid uptake and oxidation, and mitochondrial biogenesis [5].
Positive_regulation (activation) of AMPK in skeletal muscle
14) Confidence 0.34 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1964808 Disease Relevance 0.44 Pain Relevance 0
Importantly, the only three complexes that normally contribute to AMPK activity in human vastus lateralis are ?
Positive_regulation (contribute) of AMPK in vastus lateralis
15) Confidence 0.34 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1964808 Disease Relevance 0 Pain Relevance 0
Thus AMPK activation in skeletal muscle protects against the development of insulin resistance, type 2 diabetes and obesity [8]–[11].
Positive_regulation (activation) of AMPK in skeletal muscle associated with diabetes mellitus, obesity and insulin resistance
16) Confidence 0.34 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1964808 Disease Relevance 0.47 Pain Relevance 0
Studies in experimental animals demonstrate that activation of AMPK in skeletal muscle protects against insulin resistance, type 2 diabetes and obesity.
Positive_regulation (activation) of AMPK in skeletal muscle associated with diabetes mellitus, obesity and insulin resistance
17) Confidence 0.32 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC1964808 Disease Relevance 0.29 Pain Relevance 0
Of the 24 novel coding variants identified, we focused on the R225W mutation due to the established importance of the mutation in porcine AMPK ?
Positive_regulation (porcine) of AMPK
18) Confidence 0.32 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1964808 Disease Relevance 0.57 Pain Relevance 0
3 R225W mutation increases basal AMPK activity, but results in a protein that can be further activated by AMP, unlike the latter ?
Positive_regulation (increases) of AMPK
19) Confidence 0.29 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1964808 Disease Relevance 0.39 Pain Relevance 0
Most transcripts regulating cholesterol biosynthesis (FDFT1, PRKAB1) and trafficking (SCARB1, APOL2) were increased, but transcription of the secreted apolipoprotein APOL1 and a peroxisomal protein (ECHDC1) involved in beta-oxidation of cholesterol were decreased.
Positive_regulation (increased) of PRKAB1 associated with disorder of lipid metabolism
20) Confidence 0.27 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.16 Pain Relevance 0.03

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