INT10598

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Context Info
Confidence 0.64
First Reported 1989
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 3.44
Pain Relevance 1.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ar) enzyme binding (Ar) DNA binding (Ar)
transcription factor binding (Ar) cytoplasm (Ar)
Anatomy Link Frequency
exocrine glands 1
fascia 1
preoptic area 1
Ar (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 8 99.24 Very High Very High Very High
Clonidine 2 97.64 Very High Very High Very High
narcan 3 89.76 High High
antagonist 4 89.60 High High
carpal tunnel syndrome 1 79.76 Quite High
withdrawal 3 79.52 Quite High
opiate 2 75.00 Quite High
depression 1 73.64 Quite High
anesthesia 7 65.44 Quite High
Opioid 1 56.56 Quite High
Disease Link Frequency Relevance Heat
Salivary Gland Disease 18 99.48 Very High Very High Very High
Contracture 5 98.76 Very High Very High Very High
Dupuytren's Disease 7 98.48 Very High Very High Very High
Reprotox - General 1 34 96.92 Very High Very High Very High
Diabetes Mellitus 32 96.84 Very High Very High Very High
Syndrome 9 94.36 High High
Stress 95 94.20 High High
Carpal Tunnel Syndrome 1 79.76 Quite High
Cancer 2 78.36 Quite High
Coronary Artery Disease 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the binding study, Scatchard analysis of the cytosol prepared from a 17-year-old female baboon demonstrated levels of androgen receptor (as determined by the use of radiolabeled R1881) comparable to that found in young adults.
Gene_expression (levels) of androgen receptor
1) Confidence 0.64 Published 1989 Journal Anat. Rec. Section Abstract Doc Link 2540679 Disease Relevance 0.07 Pain Relevance 0.07
The hair follicles and salivary glands are exocrine glands that express the androgen receptor and share common morphological characteristics with the prostate [15]–[18].
Gene_expression (express) of androgen receptor in exocrine glands associated with salivary gland disease
2) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3011012 Disease Relevance 0.97 Pain Relevance 0
Immunohistochemical and Western blot analysis were done to determine COX-2, epidermal growth factor receptor (EGFR), Akt, androgen receptor, and cyclin D1 expression.
Gene_expression (expression) of androgen receptor
3) Confidence 0.29 Published 2007 Journal Clin. Cancer Res. Section Body Doc Link 17908994 Disease Relevance 0.08 Pain Relevance 0
Effect of E2 on androgen receptor (AR) of prostate with TP (92.6 mg/kg)
Gene_expression (Effect) of androgen receptor
4) Confidence 0.25 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2959216 Disease Relevance 0.06 Pain Relevance 0
An overall decrease in COX-2, EGFR, Akt, androgen receptor, and cyclin D1 expression was found associated with tumor growth inhibition.
Gene_expression (expression) of androgen receptor
5) Confidence 0.23 Published 2007 Journal Clin. Cancer Res. Section Body Doc Link 17908994 Disease Relevance 0.06 Pain Relevance 0
Paradoxically, the diabetes-induced reduction in serum T in ZDF-treated and untreated rats were not associated with a corresponding significant drop in intratesticular T production, or androgen receptor expression (data not shown).
Gene_expression (expression) of androgen receptor associated with diabetes mellitus
6) Confidence 0.17 Published 2009 Journal PPAR Research Section Body Doc Link PMC2696180 Disease Relevance 0.53 Pain Relevance 0
been reported to alter androgen receptor expression and adrenocortical function

[49, 50].

Gene_expression (expression) of androgen receptor
7) Confidence 0.16 Published 2009 Journal Journal of Toxicology Section Body Doc Link PMC2809433 Disease Relevance 0.07 Pain Relevance 0
Palmar fascia tissue and cultured cells from patients with Dupuytren's contracture and from normal subjects were characterized and analyzed for androgen receptor expression.
Spec (analyzed) Gene_expression (expression) of androgen receptor in fascia associated with dupuytren's disease and contracture
8) Confidence 0.12 Published 2002 Journal J. Orthop. Res. Section Abstract Doc Link 11853085 Disease Relevance 0.69 Pain Relevance 0.08
Capsaicin, a component of red peppers, induces expression of androgen receptor via PI3K and MAPK pathways in prostate LNCaP cells.
Gene_expression (expression) of androgen receptor associated with qutenza
9) Confidence 0.06 Published 2009 Journal FEBS Lett. Section Title Doc Link 19059400 Disease Relevance 0.09 Pain Relevance 0.79
Prazosin had a tendency to produce dihydrotestosterone (DHT) indicating a facilitation of 5 alpha-reductase, and clonidine showed a significant production of estradiol (E2) with a slight production of DHT indicating a significant facilitation of aromatase.
Gene_expression (produce) of dihydrotestosterone associated with clonidine
10) Confidence 0.04 Published 1992 Journal J Toxicol Sci Section Abstract Doc Link 1507273 Disease Relevance 0.21 Pain Relevance 0.47
Androgen and oestrogen receptors expressed in cells in the preoptic area and ventromedial/arcuate nuclei appear to relay the effects of T on behaviour and gonadotrophin secretion, and melatonin receptors expressed in the premammillary area relay the effects of melatonin/photoperiod.
Gene_expression (expressed) of Androgen in preoptic area
11) Confidence 0.03 Published 2001 Journal Reprod. Fertil. Dev. Section Abstract Doc Link 11999307 Disease Relevance 0.61 Pain Relevance 0.20

General Comments

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