INT105983

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Context Info
Confidence 0.48
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.82
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp9) extracellular space (Mmp9) extracellular region (Mmp9)
proteinaceous extracellular matrix (Mmp9) extracellular matrix organization (Mmp9) protein complex (Mmp9)
Anatomy Link Frequency
livers 2
connective tissue 2
Mmp9 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 46 100.00 Very High Very High Very High
Paracetamol 9 99.04 Very High Very High Very High
Inflammation 48 85.44 High High
cytokine 8 81.12 Quite High
Inflammatory mediators 1 74.96 Quite High
Inflammatory response 5 68.96 Quite High
fibrosis 40 60.84 Quite High
rheumatoid arthritis 1 49.44 Quite Low
halothane 3 5.00 Very Low Very Low Very Low
Bile 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 14 100.00 Very High Very High Very High
Cancer 5 100.00 Very High Very High Very High
Fibrosis 53 99.64 Very High Very High Very High
Chronic Hepatitis 1 99.08 Very High Very High Very High
Hepatitis Virus Infection 1 97.40 Very High Very High Very High
Cirrhosis 18 96.44 Very High Very High Very High
Nash(non-alcoholic Steatohepatitis) 1 96.32 Very High Very High Very High
Targeted Disruption 7 94.08 High High
Liver Disease 9 93.00 High High
Autoimmune Disease 19 91.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In fibrotic animals, hepatic expression of MMP-2, MMP-3, MMP-8, MMP-9 and MMP-13 mRNA were all significantly upregulated, compared to non-fibrotic controls (Figure 6).
Positive_regulation (upregulated) of Transcription (expression) of MMP-9 associated with fibrosis
1) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 0.33 Pain Relevance 0.06
Similarly, increased mRNA levels of MMP-9 or MMP-2 have been found in the livers of patients with chronic viral hepatitis as well as nonalcoholic steatohepatitis [104].
Positive_regulation (increased) of Transcription (levels) of MMP-9 in livers associated with nash(non-alcoholic steatohepatitis) and hepatitis virus infection
2) Confidence 0.11 Published 2010 Journal Hepatitis Research and Treatment Section Body Doc Link PMC3021850 Disease Relevance 1.27 Pain Relevance 0.50
Expression of mRNA for tumor necrosis factor-alpha (TNF-alpha), interleukin-10 (IL-10), matrix metalloproteinase-9, and connective tissue growth factor (CTGF) also increased in the liver following acetaminophen treatment of wild-type mice.
Positive_regulation (increased) of Transcription (Expression) of metalloproteinase-9 in connective tissue associated with necrosis, paracetamol, cancer and metalloproteinase
3) Confidence 0.09 Published 2002 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 12392966 Disease Relevance 1.23 Pain Relevance 0.78

General Comments

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