INT105985

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Context Info
Confidence 0.66
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 8.55
Pain Relevance 3.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp9) extracellular space (Mmp9) extracellular region (Mmp9)
proteinaceous extracellular matrix (Mmp9) extracellular matrix organization (Mmp9) protein complex (Mmp9)
Anatomy Link Frequency
livers 2
connective tissue 1
MDA-MB-231 1
Mmp9 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 188 100.00 Very High Very High Very High
Paracetamol 9 96.68 Very High Very High Very High
Inflammation 253 95.24 Very High Very High Very High
fibrosis 147 92.16 High High
cytokine 66 84.64 Quite High
Inflammatory mediators 4 74.96 Quite High
Bile 9 74.36 Quite High
Inflammatory response 26 68.96 Quite High
rheumatoid arthritis 10 49.44 Quite Low
cva 1 41.88 Quite Low
Disease Link Frequency Relevance Heat
Cancer 209 100.00 Very High Very High Very High
Necrosis 27 100.00 Very High Very High Very High
Fibrosis 159 99.64 Very High Very High Very High
Hydronephrosis 154 98.48 Very High Very High Very High
Chronic Hepatitis 1 98.48 Very High Very High Very High
Hepatitis Virus Infection 1 97.40 Very High Very High Very High
Wound Healing 14 96.52 Very High Very High Very High
Nash(non-alcoholic Steatohepatitis) 1 96.32 Very High Very High Very High
Cirrhosis 35 95.84 Very High Very High Very High
INFLAMMATION 278 95.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In fibrotic animals, hepatic expression of MMP-2, MMP-3, MMP-8, MMP-9 and MMP-13 mRNA were all significantly upregulated, compared to non-fibrotic controls (Figure 6).
Transcription (expression) of MMP-9 associated with fibrosis
1) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 0.33 Pain Relevance 0.06
Hepatic transcript levels of MMP-8 (Figure 6C) and MMP-9 (Figure 6D) were 5.6-fold and 6.6-fold increased, respectively, in livers from Marimastat treated animals, whereas hepatic MMP-13 transcripts were 3.0-fold higher in the vehicle treated animals (Figure 6E).
Transcription (transcript) of MMP-9 in livers
2) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 0.23 Pain Relevance 0.03
Reduction in the mRNA levels of MMP-9, uPAR and cathepsin B in M-sh, U-sh and C-sh transfected 4910 cells indicated a downregulation of MMP-9, uPAR and cathespin B target mRNAs, the mechanism by which shRNAs are proposed to work [24], [25].
Transcription (levels) of MMP-9
3) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904700 Disease Relevance 0.18 Pain Relevance 0
Our data show a strong upregulation of the mRNA expression of collagenase (MMP1) and both gelatinases (MMP2 and MMP9) compared with controls.
Transcription (expression) of MMP9
4) Confidence 0.38 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC2933604 Disease Relevance 0.38 Pain Relevance 0.19
Surprisingly, MMP2/TIMP2 and MMP9/TIMP1 mRNA expression and MMP9 activity was considerably reduced in TLR2?
Transcription (expression) of MMP9 associated with hydronephrosis
5) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682651 Disease Relevance 1.42 Pain Relevance 0.35
Surprisingly, MMP2/TIMP2 and MMP9/TIMP1 mRNA expression and MMP9 activity was considerably reduced in TLR2?
Transcription (expression) of MMP9 associated with hydronephrosis
6) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682651 Disease Relevance 1.43 Pain Relevance 0.36
Real-time RT-PCR analysis indicated that THL could inhibit the transcription of the MMP-2 and MMP-9 genes in MDA-MB-231 cells (see Additional file 2: Supplemental figure S2).
Transcription (transcription) of MMP-9 in MDA-MB-231 associated with metalloproteinase
7) Confidence 0.23 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2880989 Disease Relevance 0.80 Pain Relevance 0.44
Similarly, increased mRNA levels of MMP-9 or MMP-2 have been found in the livers of patients with chronic viral hepatitis as well as nonalcoholic steatohepatitis [104].
Transcription (levels) of MMP-9 in livers associated with nash(non-alcoholic steatohepatitis) and hepatitis virus infection
8) Confidence 0.16 Published 2010 Journal Hepatitis Research and Treatment Section Body Doc Link PMC3021850 Disease Relevance 1.26 Pain Relevance 0.50
To detect MMP-9 and MMP-2 activity, cell culture medium was collected and concentrated.
Transcription (detect) of MMP-9 associated with metalloproteinase
9) Confidence 0.14 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2988746 Disease Relevance 0.05 Pain Relevance 0.16
Expression of mRNA for tumor necrosis factor-alpha (TNF-alpha), interleukin-10 (IL-10), matrix metalloproteinase-9, and connective tissue growth factor (CTGF) also increased in the liver following acetaminophen treatment of wild-type mice.
Transcription (Expression) of metalloproteinase-9 in connective tissue associated with necrosis, paracetamol, cancer and metalloproteinase
10) Confidence 0.12 Published 2002 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 12392966 Disease Relevance 1.21 Pain Relevance 0.71
1, CCL2, VEGF, MMP-9 and TIMP-2 protein and mRNA expression (Saika et al 2005).
Transcription (expression) of MMP-9 associated with metalloproteinase
11) Confidence 0.11 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 1.26 Pain Relevance 0.22

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