INT105986

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Context Info
Confidence 0.69
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 2.43
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ctgf) cytosol (Ctgf) extracellular space (Ctgf)
extracellular region (Ctgf) Golgi apparatus (Ctgf) proteinaceous extracellular matrix (Ctgf)
Anatomy Link Frequency
PSC 4
connective tissue 2
Ctgf (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 1 100.00 Very High Very High Very High
Paracetamol 8 99.04 Very High Very High Very High
Inflammation 1 85.44 High High
alcohol 4 80.48 Quite High
Inflammatory mediators 1 74.96 Quite High
fibrosis 4 68.48 Quite High
Chronic pancreatitis 2 62.96 Quite High
cytokine 1 44.40 Quite Low
Disease Link Frequency Relevance Heat
Necrosis 3 100.00 Very High Very High Very High
Cancer 2 100.00 Very High Very High Very High
Primary Sclerosing Cholangitis 14 99.64 Very High Very High Very High
Stress 2 99.38 Very High Very High Very High
Targeted Disruption 4 94.08 High High
Injury 2 87.60 High High
INFLAMMATION 3 85.44 High High
Hepatotoxicity 2 75.00 Quite High
Fibrosis 4 68.48 Quite High
Pancreatitis 2 62.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results show the production of acetaldehyde and oxidant stress in mouse PSC are the cause of increased CCN2 mRNA and protein production after exposure of the cells to ethanol.
Positive_regulation (increased) of Transcription (production) of CCN2 in PSC associated with stress and primary sclerosing cholangitis
1) Confidence 0.69 Published 2009 Journal Growth Factors Section Abstract Doc Link 19280452 Disease Relevance 0.48 Pain Relevance 0.03
In the presence of 4MP, DAS, or the anti-oxidants vitamin D or catalase, there was a substantial decrease in the ability of ethanol to stimulate CCN2 mRNA expression and a concomitant decrease in CCN2-positive PSC.
Positive_regulation (stimulate) of Transcription (expression) of CCN2 in PSC associated with primary sclerosing cholangitis
2) Confidence 0.47 Published 2009 Journal Growth Factors Section Abstract Doc Link 19280452 Disease Relevance 0.72 Pain Relevance 0.20
Expression of mRNA for tumor necrosis factor-alpha (TNF-alpha), interleukin-10 (IL-10), matrix metalloproteinase-9, and connective tissue growth factor (CTGF) also increased in the liver following acetaminophen treatment of wild-type mice.
Positive_regulation (increased) of Transcription (Expression) of CTGF in connective tissue associated with necrosis, paracetamol, cancer and metalloproteinase
3) Confidence 0.43 Published 2002 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 12392966 Disease Relevance 1.23 Pain Relevance 0.78

General Comments

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