INT105991

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Context Info
Confidence 0.38
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 6.31
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lysosome (IDS)
Anatomy Link Frequency
plasma 1
muscle 1
brain 1
urine 1
IDS (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 172 93.20 High High
Central nervous system 17 78.72 Quite High
imagery 88 71.84 Quite High
nud 1 65.76 Quite High
anesthesia 9 62.72 Quite High
adenocard 12 58.32 Quite High
headache 2 36.96 Quite Low
abdominal pain 6 28.88 Quite Low
tolerance 12 5.00 Very Low Very Low Very Low
Spinal cord 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Mucopolysaccharidoses 177 100.00 Very High Very High Very High
Disease 151 100.00 Very High Very High Very High
Multiple Sulfatase Deficiency Disease 15 100.00 Very High Very High Very High
Sialidosis 7 100.00 Very High Very High Very High
Mucopolysaccharidosis Ii 17 99.84 Very High Very High Very High
Syndrome 27 98.48 Very High Very High Very High
Gangliosidoses 1 97.88 Very High Very High Very High
Cleidocranial Dysplasia 13 96.64 Very High Very High Very High
Aging 31 93.40 High High
Angina 112 93.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mucopolysaccharidosis type II or Hunter syndrome is rare and is caused by a deficiency of iduronate-2-sulfatase.
Negative_regulation (deficiency) of iduronate-2-sulfatase associated with mucopolysaccharidoses and mucopolysaccharidosis ii
1) Confidence 0.38 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2890619 Disease Relevance 1.28 Pain Relevance 0.04
Somatic gene therapy appears therefore to be suitable to correct IDS deficiency in brain cells.
Negative_regulation (deficiency) of IDS in brain
2) Confidence 0.38 Published 2002 Journal Biochim. Biophys. Acta Section Abstract Doc Link 12393174 Disease Relevance 0.24 Pain Relevance 0.10
But mean number of IDs used is higher than that observed previously (1.68) (16).
Negative_regulation (number) of IDs
3) Confidence 0.34 Published 2009 Journal McGill Journal of Medicine : MJM Section Body Doc Link PMC2687907 Disease Relevance 0 Pain Relevance 0
When the reference standard for diagnosis, in this case coronary angiography, is not used in all patients and referral to angiography is more likely when MPS is abnormal, then the findings are affected by referral bias and specificity appears falsely low [74, 75, 76, 77, 78, 79, 80, 81].
Negative_regulation (abnormal) of MPS
4) Confidence 0.24 Published 2003 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC2562441 Disease Relevance 0.19 Pain Relevance 0.05
Target waiting times are almost achieved for urgent patients but at the expense of the less urgent.Fig. 10 Histogram of waiting times for MPS from the BNCS 2000 UK survey

Nature and quality of MPS in the UK

Negative_regulation (waiting) of MPS
5) Confidence 0.23 Published 2003 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC2562441 Disease Relevance 0.09 Pain Relevance 0.04
MPS, Regular user of MPS; non-MPS, occasional user of MPS. [252]
Negative_regulation (user) of MPS
6) Confidence 0.23 Published 2003 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC2562441 Disease Relevance 0.92 Pain Relevance 0.39
MPS, Regular user of MPS; non-MPS, occasional user of MPS. [252]
Negative_regulation (user) of MPS
7) Confidence 0.23 Published 2003 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC2562441 Disease Relevance 0.92 Pain Relevance 0.39
After 53 weeks of therapy, urine glycosaminoglycan levels were significantly decreased in both idursulfase treatment groups compared to placebo (p < 0.0001).
Negative_regulation (decreased) of idursulfase in urine
8) Confidence 0.16 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721351 Disease Relevance 0.06 Pain Relevance 0
The slightly greater postabsorptive plasma leucine concentration in men, which is in excellent agreement with an earlier report on sex differences in the plasma amino acid profile [52], probably reflects greater net negative protein balance in men than in women but it is difficult to assign components to this, beyond the decreased MPS in men.
Negative_regulation (decreased) of MPS in plasma
9) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2267222 Disease Relevance 0.07 Pain Relevance 0
There is also evidence that ovarian hormones inhibit MPS [17] and muscle growth [18], [19] in rats.
Negative_regulation (inhibit) of MPS in muscle
10) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2267222 Disease Relevance 0.05 Pain Relevance 0
On the other hand, there is evidence from studies in rats that progesterone and estrogen inhibit MPS.
Negative_regulation (inhibit) of MPS
11) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2267222 Disease Relevance 0.25 Pain Relevance 0
The radiological findings that are characteristic of MPS VI, other MPS, mucolipidoses (ML II I-Cell disease/Leroy, ML III (pseudo-Hurler polydystrophy) and other storage diseases (multiple sulfatase deficiency, carbohydrate-deficient glycoprotein syndrome, GM I gangliosidosis and geleophysic dysplasia) are given the term "dysostosis multiplex".
Negative_regulation (deficiency) of MPS associated with gangliosidoses, sialidosis, syndrome, mucopolysaccharidoses, cleidocranial dysplasia, multiple sulfatase deficiency disease and disease
12) Confidence 0.01 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2873242 Disease Relevance 2.23 Pain Relevance 0.03

General Comments

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