INT105993

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Context Info
Confidence 0.78
First Reported 2002
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 26
Total Number 26
Disease Relevance 10.83
Pain Relevance 2.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lysosome (IDS)
Anatomy Link Frequency
chest 3
muscle 2
brain 1
neuronal 1
glial cells 1
IDS (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 301 99.48 Very High Very High Very High
Central nervous system 53 97.24 Very High Very High Very High
imagery 152 92.32 High High
Pain 59 90.56 High High
corticosteroid 13 88.36 High High
anesthesia 7 88.24 High High
Antihistamine 20 87.44 High High
abdominal pain 12 73.56 Quite High
depression 26 69.92 Quite High
headache 4 69.28 Quite High
Disease Link Frequency Relevance Heat
Coronary Artery Disease 315 100.00 Very High Very High Very High
Disease 366 99.88 Very High Very High Very High
Angina 196 99.48 Very High Very High Very High
Syndrome 44 99.04 Very High Very High Very High
Myocardial Infarction 171 98.68 Very High Very High Very High
Stress 248 98.24 Very High Very High Very High
Metatarsalgia 54 98.16 Very High Very High Very High
Infarction 84 98.04 Very High Very High Very High
Testosterone Deficiency 2 97.12 Very High Very High Very High
Cv Unclassified Under Development 105 96.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this work, as a potential treatment for this disease, the transfer of the recombinant IDS enzyme into brain cells has been studied in vitro.
Gene_expression (transfer) of IDS enzyme in brain associated with disease
1) Confidence 0.78 Published 2002 Journal Biochim. Biophys. Acta Section Abstract Doc Link 12393174 Disease Relevance 0.34 Pain Relevance 0.14
Our data indicate that the transfected as well as the infected cells produce a large amount of the IDS enzyme, which is efficiently endocytosed into neuronal and glial cells through the mannose 6-phosphate (M6P) receptor system.
Gene_expression (produce) of IDS enzyme in glial cells
2) Confidence 0.78 Published 2002 Journal Biochim. Biophys. Acta Section Abstract Doc Link 12393174 Disease Relevance 0.28 Pain Relevance 0.11
Idursulfase is produced in a continuous human cell line and is a purified form of the natural lysosomal enzyme I2S.
Gene_expression (produced) of Idursulfase
3) Confidence 0.66 Published 2007 Journal Eur J Pediatr Section Body Doc Link PMC2234442 Disease Relevance 0.29 Pain Relevance 0
Enzyme replacement therapy using idursulfase (Elaprase), a recombinant human 12S produced in the human cell line, has been recently approved in the United States and the European Union for the management of MPS type II.
Gene_expression (produced) of idursulfase associated with mucopolysaccharidoses
4) Confidence 0.59 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2890619 Disease Relevance 1.44 Pain Relevance 0
It was used to inform the UK National Institute of Clinical Excellence in their appraisal of MPS in patients with chest pain and myocardial infarction.
Gene_expression (appraisal) of MPS in chest associated with angina and myocardial infarction
5) Confidence 0.37 Published 2003 Journal Eur J Nucl Med Mol Imaging Section Abstract Doc Link PMC2562441 Disease Relevance 0.53 Pain Relevance 0.23
Travin and colleagues used MPS in 134 patients within 14 days of uncomplicated infarction and showed that the extent of ischaemia was the only significant predictor of future cardiac events on Cox regression analysis (Fig. 4) [248].
Gene_expression (used) of MPS associated with cv unclassified under development and infarction
6) Confidence 0.37 Published 2003 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC2562441 Disease Relevance 0.87 Pain Relevance 0.03
No targets were proposed for MPS except indirectly by requiring completion of diagnosis and assessment in rapid access chest pain clinics within 2 weeks.
Neg (except) Gene_expression (proposed) of MPS in chest associated with angina
7) Confidence 0.37 Published 2003 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC2562441 Disease Relevance 0.25 Pain Relevance 0.10
Current clinical guidelines for MPS
Gene_expression (guidelines) of MPS
8) Confidence 0.37 Published 2003 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC2562441 Disease Relevance 0.67 Pain Relevance 0.29
Complete accuracy of MPS to predict the findings at coronary angiography is neither expected nor necessary for clinical management, and when MPS is used for the diagnosis of CHD it is not being used purely to predict the presence of epicardial coronary disease.
Gene_expression (used) of MPS associated with coronary artery disease and coronary heart disease
9) Confidence 0.37 Published 2003 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC2562441 Disease Relevance 0.72 Pain Relevance 0.04
What is MPS?
Gene_expression (is) of MPS
10) Confidence 0.37 Published 2003 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC2562441 Disease Relevance 0.50 Pain Relevance 0.22
Diagnostic strategies using MPS were cheaper and equally effective compared with those that did not, both for the costs of diagnosis and for overall 2-year management costs, but patient outcome was the same (Fig. 6).Fig. 6 The 2-year costs of diagnosis (dark grey) and management (light grey) in patients without CHD but presenting with stable chest pain syndromes, according to strategy of investigation and type of hospital.
Gene_expression (presenting) of MPS in chest associated with angina, coronary artery disease and syndrome
11) Confidence 0.37 Published 2003 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC2562441 Disease Relevance 0.83 Pain Relevance 0.35
Both the scores on the SSI and item 18 of the IDS-SR were not normally distributed, because the majority of participants was non-suicidal (SSI: Skewness?
Neg (not) Gene_expression (distributed) of IDS-SR
12) Confidence 0.35 Published 2009 Journal J Psychopathol Behav Assess Section Body Doc Link PMC2914256 Disease Relevance 0.47 Pain Relevance 0.03
Idursulfase is a purified form of iduronate-2-sulfatase produced in a human cell line via recombinant DNA technology.
Gene_expression (produced) of Idursulfase
13) Confidence 0.34 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721351 Disease Relevance 0.19 Pain Relevance 0
IgE antibodies to idursulfase were not detected in either study.
Neg (not) Gene_expression (detected) of idursulfase
14) Confidence 0.30 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721351 Disease Relevance 0.13 Pain Relevance 0.19
IgG antibodies to idursulfase were detected in approximately 50% of patients, the highest prevalence of which occurred after 27 weeks of therapy (44.4% of patients).
Gene_expression (detected) of idursulfase
15) Confidence 0.30 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721351 Disease Relevance 0.70 Pain Relevance 0.23
Our data indicate that the transfected as well as the infected cells produce a large amount of the IDS enzyme, which is efficiently endocytosed into neuronal and glial cells through the mannose 6-phosphate (M6P) receptor system.
Gene_expression (produce) of IDS enzyme in neuronal
16) Confidence 0.26 Published 2002 Journal Biochim. Biophys. Acta Section Abstract Doc Link 12393174 Disease Relevance 0.28 Pain Relevance 0.11
Elaprase® (idursulfase; Shire HGT Pharmaceuticals, Cambridge, MA) was approved in the US in July, 2006 and Europe in January, 2007 for the treatment of individuals with MPS II at a recommended dose of 0.5 mg/kg administered once weekly as an intravenous infusion.
Gene_expression (approved) of idursulfase
17) Confidence 0.26 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721351 Disease Relevance 0.38 Pain Relevance 0
Fig. 1Dendrogram showing the results of unsupervised hierarchical clustering of the 1,145 probes encompassing the 892 priority genes (corresponding Affymetrix probe IDs and expression data are provided online in SI_Figure_1).
Gene_expression (expression) of IDs
18) Confidence 0.20 Published 2008 Journal Neurogenetics Section Body Doc Link PMC2238789 Disease Relevance 0.24 Pain Relevance 0
Applying MPs is an effective method to reduce pressure loading under the MH and relieve the symptoms of metatarsalgia.
Gene_expression (Applying) of MPs associated with metatarsalgia
19) Confidence 0.17 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1712337 Disease Relevance 0.44 Pain Relevance 0.08
Teardrop-shaped MPs made of polyurethane foam were applied just proximal to the second MH by an experienced physiatrist.
Gene_expression (made) of MPs in proximal
20) Confidence 0.15 Published 2006 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC1712337 Disease Relevance 0.66 Pain Relevance 0.25

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