INT105998

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Context Info
Confidence 0.95
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.88
Pain Relevance 4.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprm1) plasma membrane (Oprm1) signal transducer activity (Oprm1)
Anatomy Link Frequency
neurons 1
Oprm1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 208 100.00 Very High Very High Very High
mu opioid receptor 22 100.00 Very High Very High Very High
Opioid 60 99.24 Very High Very High Very High
Immobilon 8 99.18 Very High Very High Very High
agonist 29 96.08 Very High Very High Very High
antagonist 17 94.48 High High
Morphine 170 92.24 High High
Spinal cord 7 89.68 High High
Dorsal horn 3 88.92 High High
Intracerebroventricular 5 87.88 High High
Disease Link Frequency Relevance Heat
Neuroblastoma 10 98.54 Very High Very High Very High
Urological Neuroanatomy 30 63.28 Quite High
Nociception 9 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Sprains And Strains 3 5.00 Very Low Very Low Very Low
Drug Dependence 3 5.00 Very Low Very Low Very Low
Decapitation 2 5.00 Very Low Very Low Very Low
Inflammatory Pain 2 5.00 Very Low Very Low Very Low
Intractable Pain 2 5.00 Very Low Very Low Very Low
Apoptosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, these results suggest that etorphine-induced down-regulation may depend upon mu-opioid receptor degradation and changes in dynamin-2-mediated receptor trafficking.
Protein_catabolism (degradation) of mu-opioid receptor associated with opioid receptor and immobilon
1) Confidence 0.95 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15363980 Disease Relevance 0 Pain Relevance 0.91
to the MOR to promote the Src-mediated phosphorylation of the Tyr1325 NMDAR2A subunit.
Protein_catabolism (promote) of MOR associated with opioid receptor
2) Confidence 0.48 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2890584 Disease Relevance 0.13 Pain Relevance 0.97
Treatment of N2A cells with the selective mu-opioid ligand (DAMGO) increased the rate of MOR degradation.
Protein_catabolism (degradation) of MOR associated with neuroblastoma, mu opioid receptor and opioid
3) Confidence 0.47 Published 2002 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12393267 Disease Relevance 0.41 Pain Relevance 0.54
Cells were labeled with [35S]methionine for 24 h and MOR degradation was quantified by immunoprecipitation using monoclonal anti (MOR) antibody followed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis autoradiography.
Protein_catabolism (degradation) of MOR associated with mu opioid receptor
4) Confidence 0.47 Published 2002 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12393267 Disease Relevance 0.35 Pain Relevance 0.48
It has been reported that these MOR species are rapidly degraded by the proteosome in HEK 293 cells [31] and our observations suggest a similar situation in spinal neurons.
Protein_catabolism (degraded) of MOR in neurons
5) Confidence 0.41 Published 2007 Journal Mol Pain Section Body Doc Link PMC1947952 Disease Relevance 0 Pain Relevance 1.19

General Comments

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