INT106004

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.67
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 5.96
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PLAUR) extracellular region (PLAUR) plasma membrane (PLAUR)
enzyme binding (PLAUR)
Anatomy Link Frequency
plasma 2
monocytes 2
endometrium 2
PGE2 2
PLAUR (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 3 97.92 Very High Very High Very High
Inflammation 17 97.08 Very High Very High Very High
cINOD 7 84.16 Quite High
aspirin 5 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Dismenorea 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 27 99.98 Very High Very High Very High
Adhesions 37 99.60 Very High Very High Very High
Cv General 3 Under Development 3 97.92 Very High Very High Very High
INFLAMMATION 20 97.08 Very High Very High Very High
Colon Cancer 41 94.80 High High
Cancer 57 91.24 High High
Melanoma 73 86.16 High High
Necrosis 3 81.04 Quite High
Peptic Ulcer 3 78.72 Quite High
Apoptosis 11 75.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression level of uPAR mRNA increased in a dose-dependent manner on IL-1beta stimulation.
Positive_regulation (increased) of Gene_expression (expression) of uPAR mRNA
1) Confidence 0.67 Published 2003 Journal Dig. Dis. Sci. Section Abstract Doc Link 14714609 Disease Relevance 0.46 Pain Relevance 0.07
The increased uPAR mRNA expression caused by IL-1beta was reduced to the basal level by treatment with 50 microM indomethacin.
Positive_regulation (increased) of Gene_expression (expression) of uPAR mRNA
2) Confidence 0.67 Published 2003 Journal Dig. Dis. Sci. Section Abstract Doc Link 14714609 Disease Relevance 0.45 Pain Relevance 0.15
In conclusion, we found that uPAR expression is elevated on monocytes in AMI and contributes to enhanced cell adhesion.
Positive_regulation (elevated) of Gene_expression (expression) of uPAR in monocytes associated with adhesions and myocardial infarction
3) Confidence 0.61 Published 2002 Journal Blood Section Abstract Doc Link 12393744 Disease Relevance 1.21 Pain Relevance 0.04
Incubation of monocytic MonoMac6 cells with plasma from patients with AMI enhanced uPAR messenger RNA expression and cell adhesion to HUVECs.
Positive_regulation (enhanced) of Gene_expression (expression) of uPAR in plasma associated with adhesions and myocardial infarction
4) Confidence 0.61 Published 2002 Journal Blood Section Abstract Doc Link 12393744 Disease Relevance 1.59 Pain Relevance 0.06
In 20 patients with AMI, uPAR surface expression (measured by flow cytometry) was increased compared with that in patients with chronic stable angina (mean +/- SD fluorescence, 179 +/- 96 vs 80 +/- 53; P =.002).
Positive_regulation (increased) of Gene_expression (expression) of uPAR associated with angina and myocardial infarction
5) Confidence 0.54 Published 2002 Journal Blood Section Abstract Doc Link 12393744 Disease Relevance 0.86 Pain Relevance 0.10
The expression level of uPAR mRNA and the amount of uPA antigen on cell surfaces increased in a dose-dependent manner on treatment with PGE2 (10 and 50 ng/ml).
Positive_regulation (increased) of Gene_expression (expression) of uPAR mRNA in PGE2
6) Confidence 0.48 Published 2003 Journal Dig. Dis. Sci. Section Abstract Doc Link 14714609 Disease Relevance 0.22 Pain Relevance 0.13
In addition, expression of urokinase-type plasminogen activator receptor (PLAUR) was upregulated by curcumin (Figure 3).
Positive_regulation (upregulated) of Gene_expression (expression) of PLAUR
7) Confidence 0.40 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.46 Pain Relevance 0
Global transcript profiling identified a signature featuring decreased expression of developmental and lineage specification genes including MITF, EDNRB, DCT, and TYR, and increased expression of genes involved in interaction with the extracellular environment, such as PLAUR, VCAN, and HIF1a.
Positive_regulation (increased) of Gene_expression (expression) of PLAUR
8) Confidence 0.24 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2794539 Disease Relevance 0.70 Pain Relevance 0
CONCLUSIONS: The slow levonorgestrel-release intrauterine device use results in high expression of fibrinolytic inhibitors (PAI-1/2) and upregulated u-PAR expression in the endometrium.
Positive_regulation (upregulated) of Gene_expression (expression) of u-PAR in endometrium
9) Confidence 0.02 Published 2007 Journal J. Thromb. Haemost. Section Body Doc Link 17010149 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox