INT106010

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Context Info
Confidence 0.26
First Reported 2002
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.91
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Bmp2) extracellular space (Bmp2) growth (Bmp2)
extracellular region (Bmp2) embryo development (Bmp2) protein complex (Bmp2)
Anatomy Link Frequency
ligaments 1
crest 1
Bmp2 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 1 97.16 Very High Very High Very High
backache 1 50.16 Quite High
Pain score 1 48.64 Quite Low
Disease Link Frequency Relevance Heat
Pain 2 97.16 Very High Very High Very High
Calcification 1 96.52 Very High Very High Very High
Osteosclerosis 1 95.92 Very High Very High Very High
Disease 1 93.88 High High
Stress 1 82.64 Quite High
Pressure Volume 2 Under Development 1 78.64 Quite High
Toxicity 2 75.00 Quite High
Hypocalcemia 1 64.48 Quite High
Hypercalcemia 1 62.56 Quite High
Osteoporosis 1 57.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The investigational group (143 patients) received rhBMP-2 on an absorbable collagen sponge, and a control group (136 patients) received autogenous iliac crest bone graft.
Positive_regulation (received) of rhBMP-2 in crest
1) Confidence 0.26 Published 2002 Journal J Spinal Disord Tech Section Abstract Doc Link 12394656 Disease Relevance 0.22 Pain Relevance 0.05
Owing to the affinity for calcifited tissues, fluorine has a powerful effect on bone cellular order (mediated by growth factors' upregulation system IGF-2, TGF-beta, PDGF, bFGF, EGF, BMP-2 and PTH), on function and length, since it can provoke chronic joints-pain, ligaments-calcification, osteosclerosis.
Positive_regulation (upregulation) of BMP-2 in ligaments associated with pain, calcification and osteosclerosis
2) Confidence 0.06 Published 2004 Journal Minerva Stomatol Section Abstract Doc Link 15107774 Disease Relevance 0.69 Pain Relevance 0.10

General Comments

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