INT106018

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Context Info
Confidence 0.16
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 15
Disease Relevance 8.52
Pain Relevance 5.26

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Anatomy Mention Frequency
hippocampus 3
amygdala 1
frontal cortex 1
exoN (Rhizobium etli)
Pain Term Frequency Confidence Heat
Desipramine 8 99.98 Very High Very High Very High
Duloxetine 6 99.62 Very High Very High Very High
Hippocampus 161 98.96 Very High Very High Very High
antidepressant 32 97.28 Very High Very High Very High
bDMF 48 96.92 Very High Very High Very High
Neurotransmitter 1 96.32 Very High Very High Very High
amygdala 8 95.42 Very High Very High Very High
Potency 1 95.32 Very High Very High Very High
fluoxetine 9 93.44 High High
Serotonin 1 91.00 High High
Disease Term Frequency Confidence Heat
Status Epilepticus 8 99.96 Very High Very High Very High
Stress 512 99.84 Very High Very High Very High
Convulsion 48 99.60 Very High Very High Very High
Urological Neuroanatomy 2 99.08 Very High Very High Very High
Anxiety Disorder 192 99.00 Very High Very High Very High
Post-traumatic Stress Disorder 72 97.72 Very High Very High Very High
Decapitation 8 93.76 High High
Affective Disorder 1 79.12 Quite High
Low Back Pain 2 64.12 Quite High
Cadasil 2 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic ECS enhanced the acute induction of exon I, II and IV mRNAs but did not influence the acute upregulation of exon III mRNAs.
Positive_regulation (upregulation) of exon associated with convulsion
1) Confidence 0.16 Published 2003 Journal Neuropharmacology Section Abstract Doc Link 12907316 Disease Relevance 0.36 Pain Relevance 0.94
In contrast, chronic administration with tranylcypromine and desipramine enhanced exon II and exon III mRNAs, respectively, in discrete hippocampal and cortical subfields.
Positive_regulation (enhanced) of exon associated with desipramine
2) Confidence 0.16 Published 2003 Journal Neuropharmacology Section Abstract Doc Link 12907316 Disease Relevance 0.33 Pain Relevance 0.98
Chronic ECS enhanced the acute induction of exon I, II and IV mRNAs but did not influence the acute upregulation of exon III mRNAs.
Positive_regulation (induction) of exon associated with convulsion
3) Confidence 0.16 Published 2003 Journal Neuropharmacology Section Abstract Doc Link 12907316 Disease Relevance 0.37 Pain Relevance 0.93
In contrast, chronic administration with tranylcypromine and desipramine enhanced exon II and exon III mRNAs, respectively, in discrete hippocampal and cortical subfields.
Positive_regulation (enhanced) of exon associated with desipramine
4) Confidence 0.16 Published 2003 Journal Neuropharmacology Section Abstract Doc Link 12907316 Disease Relevance 0.33 Pain Relevance 0.98
CONCLUSIONS: The spectrum of mutations in this study can be used to plan appropriate screening protocols; a suggested protocol is to screen exon 4, and proceed to exons 3, 5, and 6 where indicated.
Positive_regulation (screen) of exon
5) Confidence 0.09 Published 2002 Journal Neurology Section Body Doc Link 12395806 Disease Relevance 0 Pain Relevance 0
RESULTS: The frequency of allele C at SNP position 30735 in exon 6 was significantly increased in AS cases (35.1%) versus controls (27.8%), as was the phenotype frequency (61.7% versus 48.6%).
Positive_regulation (increased) of exon
6) Confidence 0.09 Published 2003 Journal Arthritis Rheum. Section Body Doc Link 12847695 Disease Relevance 0.06 Pain Relevance 0
We found that chronic, but not acute, treatment with duloxetine produces a robust increase of exon V BDNF mRNA levels in frontal cortex when the animals were killed 1 or 24 h after the last administration.
Positive_regulation (increase) of exon in frontal cortex associated with urological neuroanatomy and duloxetine
7) Confidence 0.03 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 17327885 Disease Relevance 0.26 Pain Relevance 0.61
There were 5 main findings: 1) SPS rats exhibited enhancement of contextual fear relative to sham rats; 2) After FC, whereas BDNF exon IV and IX mRNA levels were increased in sham rats, BDNF exon I, IV, and IX mRNA levels were increased in SPS rats (Figure 5); 3) The levels of BDNF exon I, IV, and IX mRNA, and BDNF protein were significantly higher in SPS rats than in sham rats after FC, in agreement with the enhancement of contextual fear in SPS rats (Figure 4); 4) The levels of acetylated histone H3 and H4 at the promoters of exon I and IV of the BDNF gene were enhanced more in SPS rats than in sham rats after FC, and the levels correlated with the induction of specific BDNF exon (Figure 5); 5) No significant differences were found in the global acetylated histone H3 and H4 levels in SPS rats before versus after FC; the enhanced histone H3 and H4 acetylation in SPS rats was not due to an increase in global histone acetylation.
Positive_regulation (increased) of exon associated with stress and anxiety disorder
8) Confidence 0.01 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022311 Disease Relevance 1.20 Pain Relevance 0.04
The BDNF gene consists of nine 5' noncoding exons each linked to individual promoter regions and a 3' coding exon (IX), which codes for the BDNF preprotein amino acid sequence.30,31 Several recent studies have examined differential usage of BDNF non-coding exons during consolidation of fear learning.3,32,33 In these earlier studies, BDNF exons I and IV were transcriptionally upregulated in the amygdala during consolidation of fear learning.32,33 Bredy and colleagues34 showed that extinction of conditioned fear is accompanied by a significant increase in histone H4 acetylation at the promoter of exon IV of the BDNF gene and an increase in exon I and IV mRNA of the BDNF gene in the prefrontal cortex of mice.
Positive_regulation (increase) of exon in amygdala associated with anxiety disorder and amygdala
9) Confidence 0.01 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022311 Disease Relevance 0.68 Pain Relevance 0.12
The results of the fear conditioning study showed that footshock stress significantly increased the levels of total, exon I, and exon IV BDNF mRNA, with significantly increased acetylation levels of both histone H3 and H4, at the promoter of exons I and IV, followed by enhanced freezing to fear-context exposure.
Positive_regulation (increased) of exon associated with stress and anxiety disorder
10) Confidence 0.01 Published 2010 Journal Psychiatry Investigation Section Abstract Doc Link PMC3022311 Disease Relevance 0.75 Pain Relevance 0.08
In the present study, we found that SPS rats showed an increase in the levels of BDNF exon I, IV, and IX mRNA in the hippocampus 2 h after FC.
Positive_regulation (increase) of exon in hippocampus associated with stress and hippocampus
11) Confidence 0.01 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022311 Disease Relevance 1.05 Pain Relevance 0.08
To our knowledge, only 2 studies have examined the regulatory effect of histone acetylation on the expression of BDNF mRNA in the rat hippocampus after an acute stimulation.15,20 In response to pilocarpine-induced status epilepticus, increased levels of exon I and IV of the BDNF gene were, at least in part, derived from the hyperacetylation of histone H4 at the P2 promoter and deacetylation of histone H4 associated with the P4 promoter.20 Likewise, the marked increase in histone H4 acetylation, but not histone H3 acetylation, at the P2 promoter of the BDNF gene correlated with an increase in total BDNF mRNA in the rat hippocampus 2 h after electroconvulsive seizure.15 In contrast with our study, these previous studies indicated the importance of histone H4 acetylation at the P2 promoter in the regulation of BDNF mRNA expression.
Positive_regulation (increased) of exon in hippocampus associated with convulsion, status epilepticus and hippocampus
12) Confidence 0.01 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022311 Disease Relevance 0.48 Pain Relevance 0.19
The results of the fear conditioning study showed that footshock stress significantly increased the levels of total, exon I, and exon IV BDNF mRNA, with significantly increased acetylation levels of both histone H3 and H4, at the promoter of exons I and IV, followed by enhanced freezing to fear-context exposure.
Positive_regulation (increased) of exon associated with stress and anxiety disorder
13) Confidence 0.01 Published 2010 Journal Psychiatry Investigation Section Abstract Doc Link PMC3022311 Disease Relevance 0.75 Pain Relevance 0.08
Lubin and colleagues3 reported that only BDNF exon IV was transcriptionally upregulated in the CA1 region of the hippocampus during consolidation of fear learning.
Positive_regulation (upregulated) of exon in hippocampus associated with anxiety disorder and hippocampus
14) Confidence 0.01 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022311 Disease Relevance 0.65 Pain Relevance 0.12
There were 5 main findings: 1) SPS rats exhibited enhancement of contextual fear relative to sham rats; 2) After FC, whereas BDNF exon IV and IX mRNA levels were increased in sham rats, BDNF exon I, IV, and IX mRNA levels were increased in SPS rats (Figure 5); 3) The levels of BDNF exon I, IV, and IX mRNA, and BDNF protein were significantly higher in SPS rats than in sham rats after FC, in agreement with the enhancement of contextual fear in SPS rats (Figure 4); 4) The levels of acetylated histone H3 and H4 at the promoters of exon I and IV of the BDNF gene were enhanced more in SPS rats than in sham rats after FC, and the levels correlated with the induction of specific BDNF exon (Figure 5); 5) No significant differences were found in the global acetylated histone H3 and H4 levels in SPS rats before versus after FC; the enhanced histone H3 and H4 acetylation in SPS rats was not due to an increase in global histone acetylation.
Positive_regulation (increased) of exon associated with stress and anxiety disorder
15) Confidence 0.01 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022311 Disease Relevance 1.25 Pain Relevance 0.10

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