INT106020

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Context Info
Confidence 0.71
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 9.34
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (EPO) extracellular space (EPO) aging (EPO)
extracellular region (EPO)
Anatomy Link Frequency
liver 1
EPO (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 1 100.00 Very High Very High Very High
carbamazepine 1 99.32 Very High Very High Very High
cytokine 11 98.86 Very High Very High Very High
Inflammation 10 98.66 Very High Very High Very High
Morphine 1 97.68 Very High Very High Very High
medulla 35 82.88 Quite High
vincristine 2 45.00 Quite Low
cva 25 5.00 Very Low Very Low Very Low
palliative 10 5.00 Very Low Very Low Very Low
headache 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 28 100.00 Very High Very High Very High
Cerebral Malaria 30 99.32 Very High Very High Very High
Lifespan 3 99.32 Very High Very High Very High
Stroke 1 99.32 Very High Very High Very High
INFLAMMATION 11 98.66 Very High Very High Very High
Chronic Disease 13 97.78 Very High Very High Very High
Anaemia 417 97.40 Very High Very High Very High
Syndrome 50 97.20 Very High Very High Very High
Cancer 332 96.22 Very High Very High Very High
Hemorrhage 3 95.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There are many potential causes of anemia in a patient with cancer.1 Commonly cancer-related anemia can be attributed to the syndrome of anemia of chronic disease (ACD) which is mediated by pro-inflammatory cytokines and characterized by impaired iron utilization, reduced erythropoietin (EPO) mRNA synthesis and reduced RBC lifespan.2 This diagnosis requires exclusion of other possible causes, such as occult bleeding, iron or vitamin deficiency, autoimmune hemolysis or marrow infiltration.
Transcription (synthesis) of erythropoietin associated with syndrome, vitamin deficiency, hemorrhage, cytokine, inflammation, anaemia, cancer, lifespan, hemolysis and chronic disease
1) Confidence 0.71 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697520 Disease Relevance 2.14 Pain Relevance 0.10
There are many potential causes of anemia in a patient with cancer.1 Commonly cancer-related anemia can be attributed to the syndrome of anemia of chronic disease (ACD) which is mediated by pro-inflammatory cytokines and characterized by impaired iron utilization, reduced erythropoietin (EPO) mRNA synthesis and reduced RBC lifespan.2 This diagnosis requires exclusion of other possible causes, such as occult bleeding, iron or vitamin deficiency, autoimmune hemolysis or marrow infiltration.
Transcription (synthesis) of EPO associated with syndrome, vitamin deficiency, hemorrhage, cytokine, inflammation, anaemia, cancer, lifespan, hemolysis and chronic disease
2) Confidence 0.71 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697520 Disease Relevance 2.14 Pain Relevance 0.10
Herein, we summarize the beneficial effects of melatonin when combined with the following drugs: doxorubicin, cisplatin, epirubicin, cytarabine, bleomycin, gentamicin, ciclosporin, indometacin, acetylsalicylic acid, ranitidine, omeprazole, isoniazid, iron and erythropoietin, phenobarbital, carbamazepine, haloperidol, caposide-50, morphine, cyclophosphamide and L-cysteine.
Transcription (summarize) of erythropoietin associated with aspirin, morphine and carbamazepine
3) Confidence 0.69 Published 2002 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 12396291 Disease Relevance 0.25 Pain Relevance 0.20
Clinical trials of Epo are underway in stroke and in African children with cerebral malaria [10,11]
Transcription (trials) of Epo associated with stroke and cerebral malaria
4) Confidence 0.63 Published 2009 Journal Malar J Section Body Doc Link PMC2785829 Disease Relevance 1.01 Pain Relevance 0.21
The homeostatic balance is upheld via a sensitive system where hypoxia induces transcription of erythropoietin (Epo), produced by the kidneys.
Transcription (transcription) of erythropoietin associated with hypoxia
5) Confidence 0.57 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504072 Disease Relevance 1.06 Pain Relevance 0
The homeostatic balance is upheld via a sensitive system where hypoxia induces transcription of erythropoietin (Epo), produced by the kidneys.
Transcription (transcription) of Epo associated with hypoxia
6) Confidence 0.57 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504072 Disease Relevance 1.06 Pain Relevance 0
Human EPO is an acidic glycoprotein hormone, predominantly produced in the kidney and, to a lesser extent, the liver.17,18 Intracellular hypoxia causes increased transcription of EPO in a HIF-2?
Transcription (transcription) of EPO in liver associated with hypoxia
7) Confidence 0.53 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697520 Disease Relevance 0.93 Pain Relevance 0
and activates transcription of a variety of hypoxia-inducible genes (i.e., VEGF, EPO, TGF?
Transcription (transcription) of EPO associated with hypoxia
8) Confidence 0.24 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581790 Disease Relevance 0.75 Pain Relevance 0

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