INT106022

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Context Info
Confidence 0.59
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.12
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GSTP1) small molecule metabolic process (GSTP1) plasma membrane (GSTP1)
nucleus (GSTP1) intracellular (GSTP1) protein complex (GSTP1)
Anatomy Link Frequency
liver 1
pancreas 1
GSTP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 96 100.00 Very High Very High Very High
Chronic pancreatitis 1 99.84 Very High Very High Very High
qutenza 1 89.12 High High
peripheral neuropathy 2 55.84 Quite High
cytokine 1 20.96 Low Low
Inflammation 1 20.56 Low Low
Paresthesia 3 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
dysesthesia 3 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatitis 3 99.84 Very High Very High Very High
Leukemia 2 94.96 High High
Breast Cancer 15 92.56 High High
Death 7 90.44 High High
Muscle Disease 1 86.32 High High
Disease 28 86.08 High High
Stomach Cancer 24 84.76 Quite High
Neuropathic Pain 5 84.16 Quite High
Esophageal Cancer 2 82.28 Quite High
Necrosis 2 75.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our findings support the hypothesis that increased platinum sensitivity may in part be due to impaired GSTP1 enzyme function.
Negative_regulation (impaired) of GSTP1 enzyme
1) Confidence 0.59 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2877230 Disease Relevance 0.85 Pain Relevance 0.03
However, in another study that measured GSTP1 expression in esophageal tissue among patients receiving chemoradiation, higher expression was associated with poorer survival [23], strengthening the hypothesis that reduced levels of GSTP1 are associated with greater cell kill.
Negative_regulation (reduced) of GSTP1
2) Confidence 0.58 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1779469 Disease Relevance 0.50 Pain Relevance 0
Our previous study on phase II detoxifying enzymes, showing a significant reduction of glutathione S-transferase-pi in chronic pancreatitis compared to the normal pancreas, indicated that xenobiotic-metabolizing enzymes are involved in the pathogenesis of pancreatic diseases.
Negative_regulation (reduction) of S-transferase-pi in pancreas associated with pancreatitis and chronic pancreatitis
3) Confidence 0.38 Published 2002 Journal J. Toxicol. Environ. Health Part A Section Abstract Doc Link 12396872 Disease Relevance 0.19 Pain Relevance 0.10
Our results demonstrate the ability of selected chemopreventive agents to decrease GSTP1-1 gene expression mechanisms and could thus contribute to reduce the incidence of glutathione related drug resistance in human leukemia.
Negative_regulation (decrease) of GSTP1-1 associated with leukemia
4) Confidence 0.30 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15313406 Disease Relevance 0.40 Pain Relevance 0.09
The formation of FAEEs in the heart is an example of a non-oxidative metabolism of alcohol, and is distinguished from the oxidative metabolism of alcohol in the liver.
Negative_regulation (distinguished) of FAEEs in liver associated with alcohol
5) Confidence 0.11 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872347 Disease Relevance 0.17 Pain Relevance 0.33

General Comments

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