INT106023

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Context Info
Confidence 0.57
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.08
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (PPIG) protein folding (PPIG) nucleoplasm (PPIG)
nucleolus (PPIG) nucleus (PPIG) cytoplasm (PPIG)
Anatomy Link Frequency
liver 1
ergot 1
kidney 1
PPIG (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcium channel 1 96.96 Very High Very High Very High
Triptan 1 95.26 Very High Very High Very High
agonist 1 95.00 High High
Serotonin 23 94.64 High High
Antihistamine 1 93.84 High High
Bile 4 85.04 High High
acular 24 81.76 Quite High
headache 11 81.48 Quite High
cva 2 80.16 Quite High
Bioavailability 6 78.32 Quite High
Disease Link Frequency Relevance Heat
Rhabdomyolysis 9 99.22 Very High Very High Very High
Injury 103 99.16 Very High Very High Very High
Myositis 1 98.82 Very High Very High Very High
Nephrotoxicity 2 98.62 Very High Very High Very High
Infection 5 98.20 Very High Very High Very High
Neutropenia 3 97.08 Very High Very High Very High
Fever 3 96.60 Very High Very High Very High
Reprotox - General 2 1 96.40 Very High Very High Very High
Necrosis 1 88.28 High High
Hemorrhage 5 83.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Golgi pattern of staining and a frequent nuclear localization of CYP 2E1 in females).
Localization (localization) of CYP
1) Confidence 0.57 Published 2002 Journal J. Toxicol. Environ. Health Part A Section Abstract Doc Link 12396872 Disease Relevance 0.08 Pain Relevance 0
Golgi pattern of staining and a frequent nuclear localization of CYP 2E1 in females).
Localization (localization) of CYP
2) Confidence 0.50 Published 2002 Journal J. Toxicol. Environ. Health Part A Section Abstract Doc Link 12396872 Disease Relevance 0.08 Pain Relevance 0
For other drugs such as antiarrhythmics, antihistamines, ergot derivatives, selective serotonin receptor agonists (or triptans), gastrointestinal motility agents, erectile dysfunction agents, and calcium channel blockers, interactions can be predicted based on studies with other ritonavir-boosted protease inhibitors and what is known about tipranavir-ritonavir CYP and P-glycoprotein utilization.
Localization (utilization) of CYP in ergot associated with reprotox - general 2, calcium channel, antihistamine, triptan, agonist and serotonin
3) Confidence 0.28 Published 2007 Journal Pharmacotherapy Section Abstract Doc Link 17542771 Disease Relevance 0.21 Pain Relevance 0.29
Interaction with cyclosporine has been reported to increase the risk of nephrotoxicity, myositis, and rhabdomyolysis, partly due to the fact that both are metabolized through CYP 3A4.37 Careful consideration should be given when fenofibric acid is administered with other potential nephrotoxic drugs and, if necessary, lower doses of fenofibric acid may be used.21
Localization (metabolized) of CYP associated with nephrotoxicity, rhabdomyolysis and myositis
4) Confidence 0.10 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2922314 Disease Relevance 0.30 Pain Relevance 0.12
Aprepitant is metabolized by cytochrome P450 (CYP) 3A4 in the liver, and thus there is the potential for interactions with other agents metabolized by this enzyme.
Localization (metabolized) of CYP in liver
5) Confidence 0.10 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012554 Disease Relevance 1.12 Pain Relevance 0.12
Furthermore, as shown in Table 3, not all hepatic cytochrome P450 (CYP) enzymes are affected by AKI, and the extent of the effect on hepatic clearance via CYP may depend on the mechanism of experimental kidney injury.
Localization (clearance) of CYP in kidney associated with injury
6) Confidence 0.08 Published 2008 Journal Crit Care Section Body Doc Link PMC2646335 Disease Relevance 1.31 Pain Relevance 0
Therefore, interactions involving concurrently used systemic drugs that are metabolized by CYP are unlikely.
Localization (metabolized) of CYP
7) Confidence 0.07 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2693998 Disease Relevance 0.87 Pain Relevance 0.44
Like many other PIs, tipranavir is metabolized via the cytochrome (CYP) p450 3A4 isozyme.71 Tipranavir should always be coadministered with ritonavir because of its known inhibition of CYP 3A4 metabolism, resulting in a boosting effect.
Localization (metabolized) of CYP
8) Confidence 0.06 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2952481 Disease Relevance 0.12 Pain Relevance 0

General Comments

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